Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Adem C. Koksal"'
Autor:
Qun Wang, Yan Chen, Romana Cvitkovic, Meghan E Pennini, Chew Shun Chang, Mark Pelletier, Jessica Bonnell, Adem C Koksal, Herren Wu, William F Dall'Acqua, C Kendall Stover, Xiaodong Xiao
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170529 (2017)
Antibody therapy against antibiotics resistant Klebsiella pneumoniae infections represents a promising strategy, the success of which depends critically on the ability to identify appropriate antibody targets. Using a target-agnostic strategy, we rec
Externí odkaz:
https://doaj.org/article/532951cf688c48fc96674967c192f5c6
Autor:
Adem C. Koksal, Chelsea C. Boo, Margarita Camara, Lily Cheng, Nicholas Holoweckyj, Virginia N. Takahashi, Carolina S. Caceres, Andriani C. Patera, Antonio DiGiandomenico, Christopher Morehouse, Shonda Hawkins, Taylor S. Cohen, Melissa de los Reyes, Ashley E. Keller, Bret R. Sellman, Sonja Hess, Mark Pelletier, Ajitha Thanabalasuriar, Marcello Marelli, Abby J. Chiang, Aaron A Berlin
Publikováno v:
Science Advances. 7
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs following induction of thermal injury. These neutrophils expressed
Autor:
Ajitha, Thanabalasuriar, Abby J, Chiang, Christopher, Morehouse, Margarita, Camara, Shonda, Hawkins, Ashley E, Keller, Adem C, Koksal, Carolina S, Caceres, Aaron A, Berlin, Nicholas, Holoweckyj, Virginia N, Takahashi, Lily, Cheng, Melissa, de Los Reyes, Mark, Pelletier, Andriani C, Patera, Bret, Sellman, Sonja, Hess, Marcello, Marelli, Chelsea C, Boo, Taylor S, Cohen, Antonio, DiGiandomenico
Publikováno v:
Science Advances
Neutrophils abandon infection control during wound repair.
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs fol
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs fol
Autor:
Nantaporn Haskins, Kimberly M Cook, William F Dall'Acqua, Herren Wu, Adem C. Koksal, Bilal Omar, Andrew Garcia, Vaheh Oganesyan, Lu Shan, Kim Rosenthal, Melissa Damschroder, Yu Jiang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Neuregulin protein 1 (NRG1) is a large (> 60–amino-acid) natural peptide ligand for the ErbB protein family members HER3 and HER4. We developed an agonistic antibody modality, termed antibody ligand mimetics (ALM), by incorporating complex ligand a
Publikováno v:
Journal of Biological Chemistry. 293:6565-6577
In αI integrins, including leukocyte function–associated antigen 1 (LFA-1), ligand-binding function is delegated to the αI domain, requiring extra steps in the relay of signals that activate ligand binding and coordinate it with cytoplasmic signa
G-protein coupled receptors (GPCRs) constitute major drug targets due to their involvement in critical biological functions and pathophysiological disorders. The leading challenge in their structural and functional characterization has been the need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd26d2a92b542bd5685c1f6befea2fde
https://europepmc.org/articles/PMC6601569/
https://europepmc.org/articles/PMC6601569/
Autor:
John R. Engen, Roxana E. Iacob, Jieqing Zhu, Xianchi Dong, Chafen Lu, Bo Zhao, Adem C. Koksal, Timothy A. Springer
Integrins are adhesion receptors that transmit force across the plasma membrane between extracellular ligands and the actin cytoskeleton. In activation of the transforming growth factor-β1 precursor (pro-TGF-β1), integrins bind to the prodomain, ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbfc0ff343112d575ab22e1b1884543
https://europepmc.org/articles/PMC5586147/
https://europepmc.org/articles/PMC5586147/
Autor:
William Dall'acqua, Xiang-Qing Yu, Adem C. Koksal, Romana Cvitkovic, C. Kendall Stover, Jessica Bonnell, Yan Chen, Qun Wang, Xizhe Gao, Xiaodong Xiao, Chien-Ying Chang, Ellen O'Connor, Mark Pelletier, Herren Wu
Publikováno v:
mAbs. 9(3)
Antibodies carry out a plethora of functions through their crystallizable fragment (Fc) regions, which can be naturally tuned by the adoption of several isotypes and post-translational modifications. Protein engineering enables further Fc function mo
Autor:
Chew shun Chang, Xiaodong Xiao, Meghan Pennini, Jessica Bonnell, Romana Cvitkovic, William Dall'acqua, Adem C. Koksal, C. Kendall Stover, Yan Chen, Qun Wang, Mark Pelletier, Herren Wu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170529 (2017)
PLoS ONE, Vol 12, Iss 1, p e0170529 (2017)
Antibody therapy against antibiotics resistant Klebsiella pneumoniae infections represents a promising strategy, the success of which depends critically on the ability to identify appropriate antibody targets. Using a target-agnostic strategy, we rec
Publikováno v:
Proceedings of the National Academy of Sciences. 109:21420-21425
Sporozoite gliding motility and invasion of mosquito and vertebrate host cells in malaria is mediated by thrombospondin repeat anonymous protein (TRAP). Tandem von Willebrand factor A (VWA) and thrombospondin type I repeat (TSR) domains in TRAP conne