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Abstract 3513: The CHK1 kinase inhibitor prexasertib (LY2606368) shows potent single-agent efficacy in in vitro and in vivo models of castrate-resistant prostate cancer

Autor: Aimee Lin, Christoph Reinhard, Ann M. McNulty, Jack A. Dempsey, Adem Abel, Marguerita O’Mahony, Ricardo Martinez, Damien Gerald, Greg Donoho, Carole A. Perruzzi, Wenjuan Wu, Jennifer R. Stephens

Publikováno v: Cancer Research. 79:3513-3513

Reported genomic alterations in the DNA repair pathway in studies of castrate-resistant prostate cancer (CRPC) patients have prompted interests in targeted therapies related to the DNA damage response (DDR). CHK1 kinase plays a critical role in media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc3dd6ddf1495cde59215786303009a2
https://doi.org/10.1158/1538-7445.am2019-3513

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