Application of LDH assay for therapeutic efficacy evaluation of ex vivo tumor models

Autor: Rita Mendes, Catarina Brito, Megan C. Cox, Inês A. Isidro, Kathleen Halwachs, Fernanda Silva, Julie J Purkal, Adelyn L Zelaya-Lazo, Ana Félix, Erwin R. Boghaert, Teresa F. Mendes

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Funding Information: This work was supported by AbbVie and by iNOVA4Health – UIDB/04462/2020, a program financially supported by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Educação e Ciência, through national funds. RM and TF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8ac81b3c771941eb41563f083c9b56
https://doaj.org/article/6ba6021cf4734f4ebc89722a5ae55c02

Synergistic therapeutic benefit by combining the antibody drug conjugate, depatux-m with temozolomide in pre-clinical models of glioblastoma with overexpression of EGFR

Autor: Kedar S, Vaidya, Michael J, Mitten, Adelyn L, Zelaya-Lazo, Anatol, Oleksijew, Cory, Alvey, Hugh D, Falls, Sasmita, Mishra, Joann, Palma, Peter, Ansell, Andrew C, Phillips, Edward B, Reilly, Mark, Anderson, Erwin R, Boghaert

Publikováno v: Journal of neuro-oncology. 152(2)

Depatux-m is an antibody drug conjugate (ADC) that targets and inhibits growth of cancer cells overexpressing the epidermal growth factor receptor (EGFR) or the 2-7 deletion mutant (EGFRvIII) in tumor models in vitro and in vivo. Treatment of patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f25e29a6671b823d79b031b5bd02eb0
https://pubmed.ncbi.nlm.nih.gov/33517558