Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering.

Autor: Hori Y; Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan., Ohmine K; Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan., Katada H; Chugai Pharmabody Research Pte. Ltd, Singapore., Noguchi Y; Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan., Sato K; Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan., Nambu T; Chugai Pharmabody Research Pte. Ltd, Singapore., Adeline LR; Chugai Pharmabody Research Pte. Ltd, Singapore., Wan GS; Chugai Pharmabody Research Pte. Ltd, Singapore., Haraya K; Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan., Ozeki K; Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan., Nanami M; Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan., Tachibana T; Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan., Sampei Z; Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan., Kuramochi T; Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan., Nezu J; Research Division, Chugai Pharmaceutical Co, Ltd, Chuo-ku, Tokyo, Japan., Hattori K; Research Division, Chugai Pharmaceutical Co, Ltd, Kamakura, Japan., Igawa T; Research Division, Chugai Pharmaceutical Co, Ltd, Chuo-ku, Tokyo, Japan.

Publikováno v: MAbs [MAbs] 2022 Jan-Dec; Vol. 14 (1), pp. 2068213.