Acarbose impairs gut Bacteroides growth by targeting intracellular glucosidases

Autor: Haley A. Brown, Adeline L. Morris, Nicholas A. Pudlo, Ashley E. Hopkins, Eric C. Martens, Jonathan L. Golob, Nicole M. Koropatkin

Publikováno v: mBio, Vol 15, Iss 12 (2024)

ABSTRACT Acarbose is a type 2 diabetes medicine that prevents dietary starch breakdown into glucose by inhibiting host amylase and glucosidase enzymes. Numerous gut species in the Bacteroides genus enzymatically break down starch and change in relati

Externí odkaz: https://doaj.org/article/344f325b0e07466e98e93c86941416ed

Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii

Autor: Jens-Christian N. Poulsen, Daniel Krska, Yusuf A. Theibich, Nicole M. Koropatkin, Haley A. Brown, Johan Larsbrink, Scott Mazurkewich, Leila Lo Leggio, Adeline L. Morris

Publikováno v: Krska, D, Mazurkewich, S, Brown, H A, Theibich, Y, Poulsen, J N, Morris, A L, Koropatkin, N M, Lo Leggio, L & Larsbrink, J 2021, ' Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii ', Biochemistry, vol. 60, no. 27, pp. 2206-2220 . https://doi.org/10.1021/acs.biochem.1c00305
Biochemistry 60(27), 2206-2220 (2021). doi:10.1021/acs.biochem.1c00305

Biochemistry 60(27), 2206 - 2220 (2021). doi:10.1021/acs.biochem.1c00305
The hyperthermophilic bacterium Caldicellulosiruptor kristjansonii encodes an unusual enzyme, CkXyn10C-GE15A, which incorporates two catalytic domains, a xylanase and a glu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483c2de5e8f5a997da4e739d840aaf6e