Mechanistic analysis of Riboswitch Ligand interactions provides insights into pharmacological control over gene expression

Autor: Shaifaly Parmar, Desta Doro Bume, Colleen M. Connelly, Robert E. Boer, Peri R. Prestwood, Zhen Wang, Henning Labuhn, Krishshanthi Sinnadurai, Adeline Feri, Jimmy Ouellet, Philip Homan, Tomoyuki Numata, John S. Schneekloth

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Riboswitches are structured RNA elements that regulate gene expression upon binding to small molecule ligands. Understanding the mechanisms by which small molecules impact riboswitch activity is key to developing potent, selective ligands fo

Externí odkaz: https://doaj.org/article/47247a5564784a3ba68dbb27933830b2

Identification of Recessive Lethal Alleles in the Diploid Genome of a Candida albicans Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact

Autor: Timea Marton, Adeline Feri, Pierre-Henri Commere, Corinne Maufrais, Christophe d’Enfert, Melanie Legrand

Publikováno v: mSphere, Vol 4, Iss 1 (2019)

ABSTRACT The heterozygous diploid genome of Candida albicans is highly plastic, with frequent loss of heterozygosity (LOH) events. In the SC5314 laboratory strain, while LOH events are ubiquitous, a chromosome homozygosis bias is observed for certain

Externí odkaz: https://doaj.org/article/a4f19e583b0040988497b79b9662e61f

Factors that influence bidirectional long-tract homozygosis due to double-strand break repair in Candida albicans

Autor: Murielle Chauvel, Adeline Feri, Corinne Maufrais, Mélanie Legrand, Christophe d'Enfert, Timea Marton

Publikováno v: Genetics
Genetics, 2021, 218 (1), pp.iyab028. ⟨10.1093/genetics/iyab028⟩

Genomic rearrangements have been associated with the acquisition of adaptive phenotypes, allowing organisms to efficiently generate new favorable genetic combinations. The diploid genome of Candida albicans is highly plastic, displaying numerous geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5255a3cf9e8132550a32d8862e617c50
https://pubmed.ncbi.nlm.nih.gov/33705548

Identification of recessive lethal alleles in the diploid genome of a candida albicans laboratory strain unveils a potential role of repetitive sequences in buffering their deleterious impact

Autor: Corinne Maufrais, Christophe d'Enfert, Timea Marton, Adeline Feri, Pierre-Henri Commere, Mélanie Legrand

Publikováno v: MSphere
MSphere, American Society for Microbiology., 2019, 4 (1), pp.e00709-18. ⟨10.1128/mSphere.00709-18⟩
mSphere 1 (4), 1-17. (2019)
MSphere, 2019, 4 (1), pp.e00709-18. ⟨10.1128/mSphere.00709-18⟩
mSphere, Vol 4, Iss 1 (2019)
mSphere
mSphere, Vol 4, Iss 1, p e00709-18 (2019)

Candida albicans is a major fungal pathogen, whose mode of reproduction is mainly clonal. Its genome is highly tolerant to rearrangements, in particular loss of heterozygosity events, known to unmask recessive lethal and deleterious alleles in hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e22a0fe5f012f362e246e979b4e82d9
https://hal.inrae.fr/hal-02619101/file/2019_Marton_mSphere_1.pdf

Genome Diversity and Dynamics in Candida albicans

Autor: Marie-Elisabeth Bougnoux, Emilie Sitterlé, Natacha Sertour, Adeline Feri, Jeanne Ropars, Mélanie Legrand, Corinne Maufrais, Raphaël Loll-Krippleber, Christophe d'Enfert, Timea Marton

Publikováno v: Candida albicans: Cellular and Molecular Biology ISBN: 9783319504087

The fungal pathogen Candida albicans shows significant diversity at the genetic and phenotypic levels. In this Chapter, we review our current knowledge of the C. albicans diploid genome and its variability, the genetic structure of the C. albicans po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31c6081f78956ea0d22bcd3db7423a11
https://doi.org/10.1007/978-3-319-50409-4_11