Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Adeline, Obrecht"'
1
Akademický článek
Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model
Autor: Maud Bollenbach, Simona Nemska, Patrick Wagner, Guillaume Camelin, François Daubeuf, Adeline Obrecht, Pascal Villa, Didier Rognan, Frédéric Bihel, Jean-Jacques Bourguignon, Martine Schmitt, Nelly Frossard
Publikováno v: Molecules, Vol 26, Iss 2, p 391 (2021)
Mitogen- and Stress-Activated Kinase 1 (MSK1) is a nuclear kinase, taking part in the activation pathway of the pro-inflammatory transcription factor NF-kB and is demonstrating a therapeutic target potential in inflammatory diseases such as asthma, p
Externí odkaz: https://doaj.org/article/be77ee75372d43f0ba33a96af0aa47d9
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2
Akademický článek
Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime
Autor: André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon
Publikováno v: Biomolecules, Vol 10, Iss 6, p 858 (2020)
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholineste
Externí odkaz: https://doaj.org/article/c8ad1bdb8ca0419e90bec0584f145514
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4
Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model
Autor: François Daubeuf, Adrien Tissot, Nelly Frossard, Adeline Obrecht, Aurore Foureau, Pascal Villa, Richard Danger, Romain Kessler, Eugénie Durand, Simona Nemska, Reza Tavakoli, Marc Stern, Laurent Reber, Antoine Roux, Antoine Magnan, Sophie Brouard, Dominique Israel-Biet
Publikováno v: Transplantation. 105(6)
Background: Chronic lung allograft dysfunction (CLAD) and its obstructive form, the obliterative bronchiolitis (OB), are the main long-term complications related to high mortality rate postlung transplantation. CLAD treatment lacks a significant succ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b2dc1e1727c2139d1b132aa044389b
https://pubmed.ncbi.nlm.nih.gov/33560725
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5
Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model
Autor: François Daubeuf, Patrick Wagner, Frédéric Bihel, Martine Schmitt, Guillaume Camelin, Adeline Obrecht, Didier Rognan, Nelly Frossard, Simona Nemska, Jean-Jacques Bourguignon, Maud Bollenbach, Pascal Villa
Publikováno v: Molecules, Vol 26, Iss 391, p 391 (2021)
Molecules
Volume 26
Issue 2
Molecules, MDPI, 2021, 26 (2), pp.391. ⟨10.3390/molecules26020391⟩
Mitogen- and Stress-Activated Kinase 1 (MSK1) is a nuclear kinase, taking part in the activation pathway of the pro-inflammatory transcription factor NF-kB and is demonstrating a therapeutic target potential in inflammatory diseases such as asthma, p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aceeb21fe0934551e0f90fc0ed2db523
https://www.mdpi.com/1420-3049/26/2/391
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6
Takamalaimë, Wayana malaleja epit: une perspective holistique pour l’étude de Psidium acutangulum Mart. Ex DC. (Myrtaceae), un remède antipaludique des amérindiens wayana de Guyane
Autor: Emeline Houël, Flore Nardella, Marie Fleury, Valérie Jullian, Alexis Valentin, Catherine Vonthron-Sénécheau, Pascal Villa, Adeline Obrecht, Matthias Kaiser, Eliane Bourreau, Guillaume Odonne, Véronique Eparvier, Genevieve Bourdy, Eric Deharo, Stien, D.
Publikováno v: Pharmacopées traditionnelles des Outre-mer : de la recherche à la valorisation (Actes du 9ème colloque international sur les plantes aromatiques et médicinales de l’Outre-Mer, 7-12 Novembre 2016, Cayenne)
Pharmacopées traditionnelles des Outre-mer : de la recherche à la valorisation (Actes du 9ème colloque international sur les plantes aromatiques et médicinales de l’Outre-Mer, 7-12 Novembre 2016, Cayenne), p45-60, 2020, 9782952319959
Fleury, M. Pharmacopées traditionnelles des Outre-mer : de la recherche à la valorisation (Actes du 9ème colloque international sur les plantes aromatiques et médicinales de l’Outre-Mer, 7-12 Novembre 2016, Cayenne), Gadepam, pp.45-60, 2020, 9782952319959
HAL
Gadepam, pp.45-60, 2020, 9782952319959
Pharmacopées traditionnelles des Outre-mer : de la recherche à la valorisation (Actes du 9ème colloque international sur les plantes aromatiques et médicinales de l’Outre-Mer, 7-12 Novembre 2016, Cayenne), pp.45-60, 2020, 9782952319959
International audience
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9d5a7baa0e62369c74998a78fedbbd88
https://hal.archives-ouvertes.fr/hal-02572492
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8
Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime
Autor: Florian Nachon, Jean-François Goossens, Maria Kliachyna, Charlotte Courageux, André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Fabien Gosselet, Marie-Pierre Dehouck, Christophe Landry, Pascal Villa, José A. Dias, Rachid Baati, Catherine Rousseau, Johan Hachani, Xavier Brazzolotto, Adeline Obrecht, Jagadeesh Yerri, Aurélie Nervo
Publikováno v: Biomolecules
Biomolecules, MDPI, 2020, 10 (6), pp.858. ⟨10.3390/biom10060858⟩
Biomolecules, Vol 10, Iss 858, p 858 (2020)
Biomolecules, 2020, 10 (6), pp.858. ⟨10.3390/biom10060858⟩
Volume 10
Issue 6
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholineste
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74d9d0cec5d50f5e006050bfa428b1d
https://doi.org/10.3390/biom10060858
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9
Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation
Autor: Michel Barrot, Ipek Yalcin, François Daubeuf, Nelly Frossard, Frédéric Bihel, Martine Schmitt, Patrick Wagner, Jean-Jacques Bourguignon, Maud Bollenbach, Léa J. Becker, Baptiste Letellier, Adeline Obrecht, Muris Humo, Eric Salvat, Pascal Villa
Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 147, pp.163-182. ⟨10.1016/j.ejmech.2018.01.049⟩
4-phenylpyridin-2-yl-guanidine (5b): a new inhibitor of the overproduction of pro-inflammatory cytokines (TNFα and Il1β) was identified from a high-throughput screening of a chemical library on human peripheral blood mononuclear cells (PBMCs) after
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff5ae2e3d53d5dcbce7ceeae4c559a8
https://hal.archives-ouvertes.fr/hal-02323729
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10
Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians
Autor: Catherine Vonthron-Sénécheau, Marcel Kaiser, Pascal Villa, Flore Nardella, Guillaume Odonne, Adeline Obrecht, Didier Stien, Valérie Jullian, Geneviève Bourdy, Véronique Eparvier, Eric Deharo, Emeline Houël, Marie Fleury, Alexis Valentin, Eliane Bourreau
Publikováno v: Journal of Ethnopharmacology
Journal of Ethnopharmacology, Elsevier, 2016, 187, pp.241-248. ⟨10.1016/j.jep.2016.04.053⟩
Journal of Ethnopharmacology, 2016, 187, pp.241-248. ⟨10.1016/j.jep.2016.04.053⟩
Ethnopharmacological relevance: Psidium acutangulum Mart. ex DC is a small tree used by the Wayana Amerindians from the Upper-Maroni in French Guiana for the treatment of malaria. Aim of the study: In a previous study, we highlighted the in vitro ant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f2060ad53c41ae9899cbe78d3e201d
https://hal.sorbonne-universite.fr/hal-01313006/file/Houel_Wayanin_and.pdf
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