Characterization of the various functional pathways elicited by synthetic agonists or antagonists at the melatonin MT1 and MT2 receptors

Autor: Céline Legros, Clémence Dupré, Chantal Brasseur, Anne Bonnaud, Olivier Bruno, Damien Valour, Preety Shabajee, Adeline Giganti, Olivier Nosjean, Terrence P. Kenakin, Jean A. Boutin

Publikováno v: Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)

Abstract Melatonin is a neurohormone that translates the circadian rhythm to the peripheral organs through a series of binding sites identified as G protein‐coupled receptors MT1 and MT2. Due to minute amounts of receptor proteins in target organs,

Externí odkaz: https://doaj.org/article/08643ceb060e4077bb6c6bb5129fe136

S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization

Autor: Aakash Patel, Hala Guedouari, Elzbieta Janda, Karine Reybier, Istvan Gacsalyi, Vishalgiri Goswami, Jean A. Boutin, Adeline Giganti, Mathias Antoine, Monivan Chhour, Marie-Claude Viaud-Massuard, Hervé Da Costa, Marc Bertrand, Pierre Ducrot, Jérôme Paysant, Patrick P. Michel, Gilles Ferry, Thierry Le Diguarher, Daniel A. Kane, Françoise Nepveu, Frédéric Bouillaud, Karen Brebner, Gérald Guillaumet, Etienne C. Hirsch, Philippe Dupuis, Johann Stojko

Publikováno v: Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩
Molecular Pharmacology, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩

International audience; Quinone reductase 2 (QR2, E.C. 1.10.5.1) is an enzyme with a feature that has attracted attention for several decades: in standard conditions, instead of recognizing NAD(P)H as an electron donor, it recognizes putative metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c332ae7dd4579c5014783569d4574301
https://www.hal.inserm.fr/inserm-02334766

Murine and Human Autotaxin α, β, and γ Isoforms

Autor: Jean A. Boutin, Pascale Chomarat, Gilles Ferry, Philippe Valet, Natacha Moulharat, Benjamin Fould, Francis Cogé, Jean-Sébastien Saulnier-Blache, Jean-Pierre Galizzi, Marianne Rodriguez, Adeline Giganti

Publikováno v: Journal of Biological Chemistry. 283:7776-7789

Autotaxin is a type II ectonucleotide pyrophosphate phosphodiesterase enzyme. It has been recently discovered that it also has a lysophospholipase D activity. This enzyme probably provides most of the extracellular lysophosphatidic acid from lysophos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6bb70b8fdb8279184f5683aa35a090c
https://doi.org/10.1074/jbc.m708705200

Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal

Autor: Gilles Ferry, Adeline Giganti, Kader Thiam, Francis Cogé, Jean A. Boutin, Fabien Bertaux

Publikováno v: FEBS letters. 581(18)

Autotaxin is a member of the phosphodiesterase family of enzymes, (NPP2). It is an important secreted protein found in conditioned medium from adipocytes. It also has a putative role in the metastatic process. Based on these observation, further vali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f2400639f3308bb939e1d6039c5f5f
https://pubmed.ncbi.nlm.nih.gov/17628547

Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement

Autor: Cécile Sykes, Christophe Ampe, Adeline Giganti, Evelyne Friederich, Julie Plastino, Bassam Janji, Delphine Lentz, Marleen Van Troys

Publikováno v: Journal of cell science. 118(Pt 6)

Increasing evidence suggests that actin cross-linking or bundling proteins might not only structure the cortical actin cytoskeleton but also control actin dynamics. Here, we analyse the effects of T-plastin/T-fimbrin, a representative member of an im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5953060889c16b63d32ac9515bd1b4c
https://pubmed.ncbi.nlm.nih.gov/15741236