Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Adelinde M. Uhrmacher"'
Autor:
Pia Wilsdorf, Oliver Reinhardt, Toby Prike, Martin Hinsch, Jakub Bijak, Adelinde M. Uhrmacher
Publikováno v:
Royal Society Open Science, Vol 11, Iss 8 (2024)
Social simulation studies are complex. They typically combine various data sources and hypotheses about the system’s mechanisms that are integrated by intertwined processes of model building, simulation experiment execution and analysis. Various do
Externí odkaz:
https://doaj.org/article/8a01f8b5997643fb94d5d6f178ef2b07
Publikováno v:
Royal Society Open Science, Vol 10, Iss 7 (2023)
Studying membrane dynamics is important to understand the cellular response to environmental stimuli. A decisive spatial characteristic of the plasma membrane is its compartmental structure created by the actin-based membrane-skeleton (fences) and an
Externí odkaz:
https://doaj.org/article/0719e5b89dcc44eab55c758b15c63f26
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Clinical diagnostics of whole-exome and whole-genome sequencing data requires geneticists to consider thousands of genetic variants for each patient. Various variant prioritization methods have been developed over the last years t
Externí odkaz:
https://doaj.org/article/5dce2ef8cf3d43689c1b771f49ae7724
Autor:
Franziska Sahm, Vivica Freiin Grote, Julius Zimmermann, Fiete Haack, Adelinde M. Uhrmacher, Ursula van Rienen, Rainer Bader, Rainer Detsch, Anika Jonitz-Heincke
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Biophysical stimulation by electric fields can promote bone formation in bone defects of critical size. Even though, long-term effects of alternating electric fields on the differentiation of osteoblasts are not fully understood. Human pre-osteoblast
Externí odkaz:
https://doaj.org/article/9565400f91974f00b385e05c39742aa5
Autor:
Julius Zimmermann, Kai Budde, Nils Arbeiter, Francia Molina, Alexander Storch, Adelinde M. Uhrmacher, Ursula van Rienen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Electrical stimulation for application in tissue engineering and regenerative medicine has received increasing attention in recent years. A variety of stimulation methods, waveforms and amplitudes have been studied. However, a clear choice of optimal
Externí odkaz:
https://doaj.org/article/1c2319c5888842d6a3b3ca69add37f29
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of receptor/protein complexes. A prominent example for the decisive impact of lipid rafts on si
Externí odkaz:
https://doaj.org/article/f1c7277dfb4d4fe19305a244b58f09c1
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Background To study cell biological phenomena which depend on diffusion, active transport processes, or the locations of species, modeling and simulation studies need to take space into account. To describe the system as a collection of disc
Externí odkaz:
https://doaj.org/article/91e447e084f845d089ca46f1ad96c241
Autor:
Pia Wilsdorf, Jakob Heller, Kai Budde, Julius Zimmermann, Tom Warnke, Christian Haubelt, Dirk Timmermann, Ursula van Rienen, Adelinde M. Uhrmacher
Publikováno v:
Applied Sciences, Vol 12, Iss 16, p 7977 (2022)
With the increasing complexity of simulation studies, and thus increasing complexity of simulation experiments, there is a high demand for better support for them to be conducted. Recently, model-driven approaches have been explored for facilitating
Externí odkaz:
https://doaj.org/article/84e5162cd86146f397b51c27820818af
Autor:
Susanne Staehlke, Fiete Haack, Anna-Christin Waldner, Dirk Koczan, Caroline Moerke, Petra Mueller, Adelinde M. Uhrmacher, J. Barbara Nebe
Publikováno v:
Cells, Vol 9, Iss 8, p 1784 (2020)
The physico-chemical surface design of implants influences the surrounding cells. Osteoblasts on sharp-edged micro-topographies revealed an impaired cell phenotype, function and Ca2+ mobilization. The influence of edges and ridges on the Wnt/β-caten
Externí odkaz:
https://doaj.org/article/53b46c1a4f1243349b9cd32c46e3915f
Publikováno v:
Electronic Proceedings in Theoretical Computer Science, Vol 19, Iss Proc. FBTC 2010, Pp 70-84 (2010)
Up to now, it is not possible to obtain analytical solutions for complex molecular association processes (e.g. Molecule recognition in Signaling or catalysis). Instead Brownian Dynamics (BD) simulations are commonly used to estimate the rate of diffu
Externí odkaz:
https://doaj.org/article/76db1f39cca84f4eaea858c03883a8ce