Výsledky vyhledávání - "Adelina Shkodrani"

Deletions of Helices 2 and 3 of Human ApoA-I Are Associated with Severe Dyslipidemia following Adenovirus-Mediated Gene Transfer in ApoA-I-Deficient Mice

Autor: Horng-Yuan Kan, Vassilis I. Zannis, Angeliki Chroni, Adelina Shkodrani, Tong Liu

Publikováno v: Biochemistry. 44:4108-4117

The objective of this study was to determine the effect of two amino-terminal apolipoprotein A-I (apoA-I) deletions on high-density lipoprotein (HDL) biosynthesis and lipid homeostasis. Adenovirus-mediated gene transfer showed that the apoA-I[Delta(8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167d703e769072f7216ef8004405ffaa
https://doi.org/10.1021/bi047998l

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Substitutions of Glutamate 110 and 111 in the Middle Helix 4 of Human Apolipoprotein A-I (apoA-I) by Alanine Affect the Structure and in Vitro Functions of apoA-I and Induce Severe Hypertriglyceridemia in apoA-I-Deficient Mice

Autor: Horng-Yuan Kan, and Adelina Shkodrani, Vassilis I. Zannis, Kyriakos E. Kypreos, Irina N. Gorshkova, Angeliki Chroni

Publikováno v: Biochemistry. 43:10442-10457

Hypertriglyceridemia is a common pathological condition in humans of mostly unknown etiology. Here we report induction of dyslipidemia characterized by severe hypertriglyceridemia as a result of point mutations in human apolipoprotein A-I (apoA-I). A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb00b92ef754ce361edb18e4e58016f0
https://doi.org/10.1021/bi049782p

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Contribution of the Hormone-Response Elements of the Proximal ApoA-I Promoter, ApoCIII Enhancer, and C/EBP Binding Site of the Proximal ApoA-I Promoter to the Hepatic and Intestinal Expression of the ApoA-I and ApoCIII Genes in Transgenic Mice

Autor: Vassilis I. Zannis, Horng-Yuan Kan, Spiros Georgopoulos, Adelina Shkodrani, Markella V. Zanni, Alexandros Tzatsos, Hou Xiang Xie

Publikováno v: Biochemistry. 43:5084-5093

We have generated and studied the pattern of expression of transgenic mouse lines carrying the human apoA-I and apoCIII gene cluster mutated at different sites. In two lines, we have either mutated the hormone-response element (HRE) of element G of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1387dfdfd767c7f298fbc0dd01893a8
https://doi.org/10.1021/bi035764g

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