Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Adelina I. Sergueeva"'
Autor:
Victor R. Gordeuk, Galina Y. Miasnikova, Adelina I. Sergueeva, Felipe R. Lorenzo, Xu Zhang, Jihyun Song, David W. Stockton, Josef T. Prchal
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Externí odkaz:
https://doaj.org/article/687abc156677458087f3aba73500c39e
Autor:
Nikica Ljubas Tomasic, Lucie Piterkova, Chad Huff, Ernest Bilic, Donghoon Yoon, Galina Y. Miasnikova, Adelina I. Sergueeva, Xiaomei Niu, Sergei Nekhai, Victor Gordeuk, Josef T. Prchal
Publikováno v:
Haematologica, Vol 98, Iss 4 (2013)
Mutations of VHL (a negative regulator of hypoxia-inducible factors) have position-dependent distinct cancer phenotypes. Only two known inherited homozygous VHL mutations exist and they cause polycythemia: Chuvash R200W and Croatian H191D. We report
Externí odkaz:
https://doaj.org/article/adef9eac38274f7f83d77908abbec6d2
Autor:
Craig A. Sable, Zakari Y. Aliyu, Niti Dham, Mehdi Nouraie, Vandana Sachdev, Stanislav Sidenko, Galina Y. Miasnikova, Lydia A. Polyakova, Adelina I. Sergueeva, Daniel J. Okhotin, Vladimir Bushuev, Alan T. Remaley, Xiaomei Niu, Oswaldo L. Castro, Mark T. Gladwin, Gregory J. Kato, Josef T. Prchal, Victor R. Gordeuk
Publikováno v:
Haematologica, Vol 97, Iss 2 (2012)
Background Patients with Chuvash polycythemia, (homozygosity for the R200W mutation in the von Hippel Lindau gene (VHL)), have elevated levels of hypoxia inducible factors HIF-1 and HIF-2, often become iron-deficient secondary to phlebotomy, and have
Externí odkaz:
https://doaj.org/article/d9c537e8b8aa4aeb95cb987b860a82cf
Autor:
Galina Y. Miasnikova, Adelina I. Sergueeva, Mehdi Nouraie, Xiaomei Niu, Daniel J. Okhotin, Lydia A. Polyakova, Tomas Ganz, Josef T. Prchal, Victor R. Gordeuk
Publikováno v:
Haematologica, Vol 96, Iss 9 (2011)
The germ-line loss-of-function VHLR200W mutation is common in Chuvashia, Russia and occurs in other parts of the world. VHLR200W homozygotes have elevated hypoxia inducible factor (HIF)-1 and HIF-2 levels, increased hemoglobin concentration, propensi
Externí odkaz:
https://doaj.org/article/847a83f8fd88425ca906edf00b30042c
Autor:
Adelina I. Sergueeva, Galina Y. Miasnikova, Daniel J. Okhotin, Alla A. Levina, Zufan Debebe, Tatiana Ammosova, Xiaomei Niu, Elena A. Romanova, Sergei Nekhai, Patricia M. DiBello, Donald W. Jacobsen, Josef T. Prchal, Victor R. Gordeuk
Publikováno v:
Haematologica, Vol 93, Iss 2 (2008)
In Chuvash polycythemia, homozygous von Hippel-Lindau (VHL) 598C>T leads to increased hypoxia inducible factor-1α and 2α, thromboses and lower systemic blood pressures. Circulating homocysteine, glutathione, γ-glutamyltransferase and cysteinylglyc
Externí odkaz:
https://doaj.org/article/a0b6df9f3811423d93e8e17d7e36d486
Autor:
Galina Y. Miasnikova, Victor R. Gordeuk, Felipe R. Lorenzo, Josef T. Prchal, Adelina I. Sergueeva, Xu Zhang, Jihyun Song, David W. Stockton
Publikováno v:
Haematologica. 105:e87-e90
Autor:
Adelina I. Sergueeva, Galina Y. Miasnikova, Josef T. Prchal, Sergei Nekhai, Xu Zhang, Jihyun Song, Victor R. Gordeuk, Binal N. Shah
Publikováno v:
Br J Haematol
Autor:
Adelina I. Sergueeva, Santosh L. Saraf, Xu Zhang, Taif Hassan, Jin Han, Jihyun Song, Josef T. Prchal, Sergei Nekhai, Binal N. Shah, Mark T. Gladwin, Roberto Machado, Victor R. Gordeuk, Galina Y. Miasnikova
Publikováno v:
Blood. 138:950-950
Reticulocytosis in sickle cell disease (SCD) is driven by tissue hypoxia from hemolytic anemia and vascular occlusion. Gene expression changes caused by hypoxia and other factors during reticulocytosis may impact SCD outcomes. We detected 1226 differ
Autor:
Adelina I. Sergueeva, Galina Y. Miasnikova, Soo Jin Kim, Xu Zhang, Tsewang Tashi, Victor R. Gordeuk, Jihyun Song, Josef T. Prchal, Perumal Thiagarajan, Binal N. Shah
Publikováno v:
Blood. 136:11-12
Thrombosis is the major cause of morbidity and mortality in Chuvash erythrocytosis (CE), caused by a hypomorphic R200W mutation of the Von Hippel-Lindau (VHL) gene, a negative regulator of hypoxia inducible factors (HIFs). This mutation augments HIF
Autor:
Victor R. Gordeuk, Binal N. Shah, Adelina I. Sergueeva, Xu Zhang, Deepika Khanna, Nikolai V. Tuktanov, Jihyun Song, Ivan Sergueev, Nigel Mackman, Galina Y. Miasnikova, Josef T. Prchal
Publikováno v:
Blood. 136:36-36
Background:Chuvash erythrocytosis (CE), an inherited autosomal recessive disease endemic to Russia's mid-Volga River region, is caused by a germlineVHLC598T mutation (encoding VHLR200W) that alters oxygen sensing (PMID: 12415268). VHLR200W protein di