Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Adelheid Lempradl"'
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102535- (2023)
Summary: Exploring early embryonic gene expression is challenging due to the rate of development and the limited material available. Here, we present a protocol for ordering Drosophila embryos along a developmental pseudo-time trajectory and determin
Externí odkaz:
https://doaj.org/article/6a306c8ecfa848088955588b05661fd3
Autor:
Lisa Koshko, Sydney Scofield, Lucas Debarba, Lukas Stilgenbauer, Mikaela Sacla, Patrick Fakhoury, Hashan Jayarathne, J. Eduardo Perez-Mojica, Ellen Griggs, Adelheid Lempradl, Marianna Sadagurski
Publikováno v:
bioRxiv
The hypothalamus is essential in the regulation of metabolism, notably during critical windows of development. An abnormal hormonal and inflammatory milieu during development can trigger persistent changes in the function of hypothalamic circuits, le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987771405c43cf7ddbf87b9bcfc5c8f1
https://europepmc.org/articles/PMC9881982/
https://europepmc.org/articles/PMC9881982/
Autor:
John L Rinn, Edward B. Chuong, Mark W. Feinberg, Junchao Shi, Jennifer Cable, Erwei Song, Matthew D. Simon, Qi Chen, Howard Y. Chang, Anna Marie Pyle, Sofia A. Quinodoz, Chun-Kan Chen, Edith Heard, Jonathan E. Henninger, Amanda E. Hargrove, Dhiraj Kumar, Jeremy E. Wilusz, Rory Johnson, Marco Marcia, Adelheid Lempradl, David L. Spector, Kannanganattu V. Prasanth, Joshua T. Mendell, Juan Pablo Unfried, Samie R. Jaffrey, Allison M Porman, Sean E. McGeary, Mukesh Kumar Lalwani, Murat C. Kalem, Ling-Ling Chen, Xuhang Liu, Tetsuro Hirose, Roza K. Przanowska, Xiaohua Shen, Lamia Wahba, Lin He, Sarah D. Diermeier, Lydia M. Contreras, Lynne E. Maquat
Publikováno v:
Ann N Y Acad Sci
The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding
Publikováno v:
Cell genomics
Early organismal development consists of transformative events that lay the foundation for body formation and long-term phenotype. Despite this understanding, the rapid progression of events and the limited material available are major barriers to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64fe2a05e5d4b5b6d0d9524e50ff2b3
https://doi.org/10.1101/2022.09.26.509035
https://doi.org/10.1101/2022.09.26.509035
Autor:
Lisa Koshko, Sydney Scofield, Lucas Debarba, Lukas Stilgenbauer, Patrick Fakhoury, Hashan Jayarathne, J. Eduardo Perez-Mojica, Ellen Griggs, Adelheid Lempradl, Marianna Sadagurski
Publikováno v:
Chemosphere. 330:138738
Autor:
John Andrew Pospisilik, Ulrike Bönisch, Adelheid Lempradl, Gabriel Seifert, Steffen Heyne, Vanessa Wegert, Laura Arrigoni, Ilaria Panzeri, John Longinotto, Chih-Hsiang Yang
Publikováno v:
Journal of Visualized Experiments
Obesity is a complex disease influenced by genetics, epigenetics, the environment, and their interactions. Mature adipocytes represent the major cell type in white adipose tissue. Understanding how adipocytes function and respond to (epi)genetic and
Autor:
Boonen E, Lennart Enders, Iconomou M, Lushchak O, Sabev M, Rückert T, Marie G.L. Roth, Daniel Nätt, Unn Kugelberg, Adelheid Lempradl, Anita Öst, Lovisa Örkenby, Ian Beddows, Eduard Casas, Tanya Vavouri, Martinez Ag, John Andrew Pospisilik, Dean J. Pettinga
SummaryPreconception parental environment can reproducibly program offspring phenotype without altering the DNA sequence, yet the mechanisms underpinning this ‘epigenetic inheritance’ remains elusive. Here, we demonstrate the existence of an inta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1f1de4a96053656ee1f2ea84deb70e8
https://doi.org/10.1101/2021.03.29.436592
https://doi.org/10.1101/2021.03.29.436592
Autor:
Adelheid Lempradl
Publikováno v:
Seminars in celldevelopmental biology. 97
It is well established that lifestyle and other environmental factors have the potential to shape our own health and future. Research from the last two decades, however, provides mounting evidence that parental exposures or experiences such as dietar
Autor:
Alison Pattie, Ailith Pirie, Francis S. Collins, Charles Kooperberg, Nienke van Leeuwen, Carmel Moore, Sharon L.R. Kardia, Neil R. Robertson, Lisa Bastarache, Allan Linneberg, Peter T. Campbell, Helena Kuivaniemi, Struan F.A. Grant, Sascha Fauser, Sekar Kathiresan, Lars Lind, Erin B. Ware, Olli T. Raitakari, Dawn M. Waterworth, James G. Wilson, Markus Perola, Chris J. Packard, Michelle L. O'Donoghue, Fredrik Karpe, Roel A. Ophoff, Sailaja Vedantam, Artitaya Lophatananon, Uwe Völker, Emmanouil Tsafantakis, Hakon Hakonarson, Dajiang J. Liu, Craig E. Pennell, Xueling Sim, Jennifer E. Huffman, Sandosh Padmanabhan, Digna R. Velez Edwards, Michiel L. Bots, Ayush Giri, Renée de Mutsert, Emanuele Di Angelantonio, Nicholas J. Wareham, Jin Li, Gail P. Jarvik, Evangelos Evangelou, Anne Tybjærg-Hansen, Patricia B. Munroe, Penny Gordon-Larsen, Lia E. Bang, Ivan Brandslund, Hester M. den Ruijter, Jussi Hernesniemi, Nancy L. Heard-Costa, Angela L. Mazul, Jonathan Tyrer, Danish Saleheen, Mark J. Caulfield, John Andrew Pospisilik, Annette Peters, Caroline Hayward, Iris M. Heid, J. Wouter Jukema, Valérie Turcot, Matt Neville, Rudolf Uher, Patricia A. Peyser, Jessica D. Faul, Asif Rasheed, Shuai Wang, John C. Chambers, Jordi Corominas Galbany, Murray H. Brilliant, Yucheng Jia, Torben Hansen, Veikko Salomaa, Mary F. Feitosa, Mathias Gorski, Li-An Lin, George Dedoussis, Honghuang Lin, Ethan M. Lange, Veronique Vitart, Bratati Kahali, Alexander Teumer, Jerome I. Rotter, Wayne H-H Sheu, Vilmantas Giedraitis, Aliki-Eleni Farmaki, Lorraine Southam, Ele Ferrannini, Anette P. Gjesing, Krina T. Zondervan, Stavroula Kanoni, David J. Roberts, Rebecca S. Fine, Svati H. Shah, Tugce Karaderi, Claudia Langenberg, Stefan Johansson, Elizabeth K. Speliotes, Alexander P. Reiner, Ching-Ti Liu, Yiqin Wang, Pål R. Njølstad, Gabriel Cuellar-Partida, Amanda J. Cox, Tim D. Spector, Paul W. Franks, Anke Tönjes, John D. Rioux, Jeffrey Haessler, Paul L. Auer, Ingrid B. Borecki, Deborah J. Thompson, Weihua Zhang, John R. B. Perry, Paul Elliott, Folkert W. Asselbergs, Myriam Fornage, Ken Sin Lo, Marie Moitry, Paul Mitchell, Martin den Heijer, Zoltán Kutalik, Tune H. Pers, Kari Stefansson, Kari Kuulasmaa, Robert E. Schoen, Mark C.H. De Groot, Laura M. Yerges-Armstrong, Jing Hua Zhao, Beverley Balkau, Peggy L. Peissig, Michael Boehnke, Janie Corley, Katharine R. Owen, Unnur Thorsteinsdottir, Naveed Sattar, Sita H. Vermeulen, Thomas N. Person, Mark I. McCarthy, Paul I.W. de Bakker, David Lamparter, Poorva Mudgal, Nicholette D. Palmer, Maria Karaleftheri, Jan-Håkan Jansson, Ozren Polasek, Ruth J. F. Loos, Daniel R. Witte, Dermot F. Reilly, Anubha Mahajan, Stella Trompet, James A. Perry, Yingchang Lu, Claudia Schurmann, Yii-Der Ida Chen, Hidetoshi Kitajima, Dale R. Nyholt, John Danesh, Pamela J. Schreiner, Narisu Narisu, Jose C. Florez, Adelheid Lempradl, Gerome Breen, Torben Jørgensen, Anu Loukola, Joe Dennis, Hans-Jörgen Grabe, Vilmundur Gudnason, Timo A. Lakka, Heather M. Highland, Sven Bergmann, Marie-Pierre Dubé, Giovanni Veronesi, Martina Müller-Nurasyid, Jaakko Tuomilehto, Nele Friedrich, Joel N. Hirschhorn, Pia R. Kamstrup, Nilesh J. Samani, Josh C. Denny, Mika Kähönen, Massimiliano Cocca, Liang Sun, Karina Meidtner, Carsten A. Böger, Sara M. Willems, Marcelo P. Segura-Lepe, Johanna Kuusisto, Hanieh Yaghootkar, Konstantin Strauch, Ruth Frikke-Schmidt, Jane Gibson, Matti Uusitupa, Oscar H. Franco, Yongmei Liu, Heather M. Stringham, Rohit Varma, Grant W. Montgomery, Dennis O. Mook-Kanamori, Stefania Cappellani, Paul L. Huang, Albert V. Smith, Eric Kim, Anke R. Hammerschlag, Katherine S. Ruth, Carolina Medina-Gomez, Gerard Pasterkamp, Cristen J. Willer, Alisa K. Manning, Frida Renström, René S. Kahn, Lili Milani, Feijie Wang, Tessel E. Galesloot, Fernando Rivadeneira, Leo-Pekka Lyytikäinen, Adam S. Butterworth, Tamara B. Harris, Matthew A. Allison, Paul M. Ridker, David J. Carey, Todd L. Edwards, Panos Deloukas, Xiuqing Guo, Lawrence F. Bielak, Leena Moilanen, Heiner Boeing, Peter Kovacs, Karen L. Mohlke, Myriam Rheinberger, Cramer Christensen, Betina H. Thuesen, Mike A. Nalls, Erik Ingelsson, Nicholas G. D. Masca, Colin N. A. Palmer, Audrey E. Hendricks, Linda Broer, Vanisha Mistry, Praveen Surendran, Audrey Y. Chu, Rainer Rauramaa, Angela D'Eustacchio, Helen Griffiths, Satu Männistö, Patrick T. Ellinor, Terho Lehtimäki, Katherine E. Tansey, I. Sadaf Farooqi, Gaëlle Marenne, Anneke I. den Hollander, Jessica van Setten, Hannu Puolijoki, Tinca J. C. Polderman, Timothy M. Frayling, Niels Grarup, Eric Boerwinkle, Gonçalo R. Abecasis, Adam E. Locke, Mengmeng Du, Manuel A. Rivas, Philippe Amouyel, Jaakko Kaprio, Leslie A. Lange, Loes M. Olde Loohuis, Trevor A. Mori, Lambertus A. Kiemeney, Wei Zhao, Eva Rb Petersen, Huaixing Li, Thomas W. Winkler, Tellervo Korhonen, Kathleen Stirrups, Jean Ferrières, Wei Zhou, Ian J. Deary, Guillaume Lettre, M. Arfan Ikram, Alex W. Hewitt, Marit E. Jørgensen, Ian Ford, Liang He, Mark Walker, Stefan Gustafsson, Andre Franke, Yao Hu, Jaana Lindström, Jonathan P. Bradfield, Anne E. Justice, Kristin L. Young, Sander W. van der Laan, Shuang Feng, Yadav Sapkota, Douglas F. Easton, Cornelia M. van Duijn, Amy J. Swift, Kjell Nikus, Helen R. Warren, Christian Theil Have, Wei Gan, Steven A. Lubitz, Harvey D. White, Pirjo Komulainen, John M. Starr, Jeffrey R. O'Connel, Anette Varbo, Daniel I. Chasman, Ruifang Li-Gao, Lynne E. Wagenknecht, Matthias Blüher, Xiaowei Zhan, Thomas F. Vogt, Eleftheria Zeggini, Tamuno Alfred, Katja K.H. Aben, Lars Wallentin, Joanna M. M. Howson, Jie Yao, Eulalia Catamo, Henrik Vestergaard, Gina M. Peloso, Markku Laakso, Matthias B. Schulze, Hayato Tada, Jennifer Wessel, Andrew R. Wood, Erwin P. Bottinger, Cora E. Lewis, Robin Young, Carol A. Wang, Oddgeir L. Holmen, Andrew J. Slater, Jean-Claude Tardif, Xu Lin, Inês Barroso, Gail Davies, Tibor V. Varga, Andrew J. Lotery, Igor Rudan, Andrew T. Hattersley, Michael Stumvoll, David Ellinghaus, Andrew C. Heath, Frank Kee, Christopher P. Nelson, Donald W. Bowden, Alison M. Dunning, Marianne Benn, Oluf Pedersen, Amber A. Burt, Aniruddh P. Patel, G. Kees Hovingh, David S. Crosslin, Gorm B. Jensen, Keng-Hung Lin, Dewan S. Alam, Jian'an Luan, Ying Wu, Tõnu Esko, Kathleen Mullan Harris, Antonietta Robino, Anne U. Jackson, Eirini Marouli, Robert A. Scott, Jette Bork-Jensen, Olov Rolandsson, Nanette R. Lee, Gerard Tromp, Megan L. Grove, Suthesh Sivapalaratnam, Sameer E. Al-Harthi, Roberta McKean-Cowdin, Paolo Gasparini, Ellen W. Demerath, Marco Brumat, Maggie C.Y. Ng, Børge G. Nordestgaard, Kari E. North, Rajiv Chowdhury, Mauno Vanhala, Andrew P. Morris, Sarah E. Medland, Sune F. Nielsen, Ilaria Gandin, Øyvind Helgeland, James P. Cook, Kent D. Taylor, Andrew D. Morris, Gudmar Thorleifsson, André G. Uitterlinden, Pang Yao, Valgerdur Steinthorsdottir, Eric B. Larson, Kerrin S. Small, Cecilia M. Lindgren, Dragana Vuckovic, Mariaelisa Graff, Fotios Drenos, Jaspal S. Kooner
Publikováno v:
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L & Balkau, B & Bang, L E & Corley, J & Davies, G & Deary, I J & Hayward, C & Morris, A D & Pattie, A & Polasek, O & Rudan, I & Starr, J M & Vitart, V 2017, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Lophatananon, A, Morris, A & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-35 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Hammerschlag, A R & Polderman, T J 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Jørgensen, T & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Grarup, N, Hansen, T, Jørgensen, M E, Lin, L-A, Pedersen, O, Witte, D R, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators & Understanding Society Scientific Group 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Kee, F, Hirschhorn, J N & Loos, R J F 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T N, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bots, M L, Bottinger, E P, Bowden, D W, Brandslund, I, Breen, G, Brilliant, M H, Broer, L, Brumat, M, Burt, A A, Butterworth, A S, Campbell, P T, Cappellani, S, Carey, D J, Catamo, E, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Cocca, M, Cook, J P, Corley, J, Corominas Galbany, J, Cox, A J, Crosslin, D S, Cuellar-Partida, G, D'Eustacchio, A, Danesh, J, Davies, G, Bakker, P I W, Groot, M C H, Mutsert, R, Deary, I J, Dedoussis, G, Demerath, E W, Heijer, M, Hollander, A I, Ruijter, H M, Dennis, J G, Denny, J C, Angelantonio, E, Drenos, F, du, M, Dubé, M-P, Dunning, A M, Easton, D F, Edwards, T L, Ellinghaus, D, Ellinor, P T, Elliott, P, Evangelou, E, Farmaki, A-E, Farooqi, I S, Faul, J D, Fauser, S, Feng, S, Ferrannini, E, Ferrieres, J, Florez, J C, Ford, I, Fornage, M, Franco, O H, Franke, A, Franks, P W, Friedrich, N, Frikke-Schmidt, R, Galesloot, T E, Gan, W, Gandin, I, Gasparini, P, Gibson, J, Giedraitis, V, Gjesing, A P, Gordon-Larsen, P, Gorski, M, Grabe, H-J R, Grant, S F A, Grarup, N, Griffiths, H L, Grove, M L, Gudnason, V, Gustafsson, S, Haessler, J, Hakonarson, H, Hammerschlag, A R, Hansen, T, Harris, K M, Harris, T B, Hattersley, A T, Have, C T, Hayward, C, He, L, Heard-Costa, N L, Heath, A C, Heid, I M, Helgeland, Ø, Hernesniemi, J, Hewitt, A W, Holmen, O L, Hovingh, G K, Howson, J M M, Hu, Y, Huang, P L, Huffman, J E, Ikram, M A, Ingelsson, E, Jackson, A U, Jansson, J-H K, Jarvik, G P, Jensen, G B, Jia, Y, Johansson, S, Jørgensen, M E, Jørgensen, T, Jukema, J W, Kahali, B, Kahn, R S, Kähönen, M, Kamstrup, P R, Kanoni, S, Kaprio, J, Karaleftheri, M, Kardia, S L R, Karpe, F, Kathiresan, S, Kee, F, Kiemeney, L A, Kim, E, Kitajima, H, Komulainen, P, Kooner, J S, Kooperberg, C, Korhonen, T, Kovacs, P, Kuivaniemi, H, Kutalik, Z, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T A, Lamparter, D, Lange, E M, Lange, L A, Langenberg, C, Larson, E B, Lee, N R, Lehtimäki, T, Lewis, C E, Li, H, Li, J, Li-Gao, R, Lin, H, Lin, K-H, Lin, L-A, Lin, X, Lind, L, Lindström, J, Linneberg, A, Liu, C-T, Liu, D J, Liu, Y, Lo, K S, Lophatananon, A, Lotery, A J, Loukola, A, Luan, JA, Lubitz, S A, Lyytikäinen, L-P, Männistö, S, Marenne, G, Mazul, A L, McCarthy, M I, McKean-Cowdin, R, Medland, S E, Meidtner, K, Milani, L, Mistry, V, Mitchell, P, Mohlke, K L, Moilanen, L, Moitry, M, Montgomery, G W, Mook-Kanamori, D O, Moore, C, Mori, T A, Morris, A D, Morris, A P, Müller-Nurasyid, M, Munroe, P B, Nalls, M A, Narisu, N, Nelson, C P, Neville, M, Nielsen, S F, Nikus, K, Njølstad, P L R, Nordestgaard, B R G, Nyholt, D R, O'Connel, J R, O'Donoghue, M L, Olde Loohuis, L M, Ophoff, R A, Owen, K R, Packard, C J, Padmanabhan, S, Palmer, C N A, Palmer, N D, Pasterkamp, G, Patel, A P, Pattie, A, Pedersen, O, Peissig, P L, Peloso, G M, Pennell, C E, Perola, M, Perry, J A, Perry, J R B, Pers, T H, Person, T N, Peters, A, Petersen, E R B, Peyser, P A, Pirie, A, Polasek, O, Polderman, T J, Puolijoki, H, Raitakari, O T, Rasheed, A, Rauramaa, R, Reilly, D F, Renström, F, Rheinberger, M, Ridker, P M, Rioux, J D, Rivas, M A, Roberts, D J, Robertson, N R, Robino, A, Rolandsson, O, Rudan, I, Ruth, K S, Saleheen, D, Salomaa, V, Samani, N J, Sapkota, Y, Sattar, N, Schoen, R E, Schreiner, P J, Schulze, M B, Scott, R A, Segura-Lepe, M P, Shah, S H, Sheu, W H-H, Sim, X, Slater, A J, Small, K S, Smith, A V, Southam, L, Spector, T D, Speliotes, E K, Starr, J M, Stefansson, K, Steinthorsdottir, V, Stirrups, K E, Strauch, K, Stringham, H M, Stumvoll, M, Sun, L, Surendran, P, Swift, A J, Tada, H, Tansey, K E, Tardif, J-C, Taylor, K D, Teumer, A, Thompson, D J, Thorleifsson, G, Thorsteinsdottir, U, Thuesen, B H, Tönjes, A, Tromp, G, Trompet, S, Tsafantakis, E, Tuomilehto, J, Tybjaerg-Hansen, A, Tyrer, J P, Uher, R, Uitterlinden, A G, Uusitupa, M, Laan, S W, Duijn, C M, Leeuwen, N, van Setten, J, Vanhala, M, Varbo, A, Varga, T V, Varma, R, Velez Edwards, D R, Vermeulen, S H, Veronesi, G, Vestergaard, H, Vitart, V, Vogt, T F, Völker, U, Vuckovic, D, Wagenknecht, L E, Walker, M, Wallentin, L, Wang, F, Wang, C A, Wang, S, Wang, Y, Ware, E B, Wareham, N J, Warren, H R, Waterworth, D M, Wessel, J, White, H D, Willer, C J, Wilson, J G, Witte, D R, Wood, A R, Wu, Y, Yaghootkar, H, Yao, J, Yao, P, Yerges-Armstrong, L M, Young, R, Zeggini, E, Zhan, X, Zhang, W, Zhao, J H, Zhao, W, Zhou, W, Zondervan, K T, Rotter, J I, Pospisilik, J A, Rivadeneira, F, Borecki, I B, Deloukas, P, Frayling, T M, Lettre, G, North, K E, Lindgren, C M, Hirschhorn, J N & Loos, R J F 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-35 . https://doi.org/10.1038/s41588-017-0011-x
Nature Genetics, 50(1), 26. Nature Publishing Group
Nature Genetics
Nat. Genet. 50, 26-41 (2018)
Nature genetics, 50(1), 26-41. Nature Publishing Group
Nature Genetics, 50(1), 26-41. Nature Publishing Group
Nature genetics, vol. 50, no. 1, pp. 26-41
Nature Genetics, 50(1), 26
NATURE GENETICS
Nature genetics 50(1), 26-41 (2017). doi:10.1038/s41588-017-0011-x
Nature Genetics, 50, 26-41
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Brandslund, I, Christensen, C, Jensen, G B, Jørgensen, M E, Thuesen, B H & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-018-0050-y
Nature Genetics, 50(1), 26-35. Nature Publishing Group
Nature Genetics, 50, 1, pp. 26-41
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Lophatananon, A, Morris, A & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-35 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Hammerschlag, A R & Polderman, T J 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Jørgensen, T & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Grarup, N, Hansen, T, Jørgensen, M E, Lin, L-A, Pedersen, O, Witte, D R, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators & Understanding Society Scientific Group 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Kee, F, Hirschhorn, J N & Loos, R J F 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T N, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bots, M L, Bottinger, E P, Bowden, D W, Brandslund, I, Breen, G, Brilliant, M H, Broer, L, Brumat, M, Burt, A A, Butterworth, A S, Campbell, P T, Cappellani, S, Carey, D J, Catamo, E, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Cocca, M, Cook, J P, Corley, J, Corominas Galbany, J, Cox, A J, Crosslin, D S, Cuellar-Partida, G, D'Eustacchio, A, Danesh, J, Davies, G, Bakker, P I W, Groot, M C H, Mutsert, R, Deary, I J, Dedoussis, G, Demerath, E W, Heijer, M, Hollander, A I, Ruijter, H M, Dennis, J G, Denny, J C, Angelantonio, E, Drenos, F, du, M, Dubé, M-P, Dunning, A M, Easton, D F, Edwards, T L, Ellinghaus, D, Ellinor, P T, Elliott, P, Evangelou, E, Farmaki, A-E, Farooqi, I S, Faul, J D, Fauser, S, Feng, S, Ferrannini, E, Ferrieres, J, Florez, J C, Ford, I, Fornage, M, Franco, O H, Franke, A, Franks, P W, Friedrich, N, Frikke-Schmidt, R, Galesloot, T E, Gan, W, Gandin, I, Gasparini, P, Gibson, J, Giedraitis, V, Gjesing, A P, Gordon-Larsen, P, Gorski, M, Grabe, H-J R, Grant, S F A, Grarup, N, Griffiths, H L, Grove, M L, Gudnason, V, Gustafsson, S, Haessler, J, Hakonarson, H, Hammerschlag, A R, Hansen, T, Harris, K M, Harris, T B, Hattersley, A T, Have, C T, Hayward, C, He, L, Heard-Costa, N L, Heath, A C, Heid, I M, Helgeland, Ø, Hernesniemi, J, Hewitt, A W, Holmen, O L, Hovingh, G K, Howson, J M M, Hu, Y, Huang, P L, Huffman, J E, Ikram, M A, Ingelsson, E, Jackson, A U, Jansson, J-H K, Jarvik, G P, Jensen, G B, Jia, Y, Johansson, S, Jørgensen, M E, Jørgensen, T, Jukema, J W, Kahali, B, Kahn, R S, Kähönen, M, Kamstrup, P R, Kanoni, S, Kaprio, J, Karaleftheri, M, Kardia, S L R, Karpe, F, Kathiresan, S, Kee, F, Kiemeney, L A, Kim, E, Kitajima, H, Komulainen, P, Kooner, J S, Kooperberg, C, Korhonen, T, Kovacs, P, Kuivaniemi, H, Kutalik, Z, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T A, Lamparter, D, Lange, E M, Lange, L A, Langenberg, C, Larson, E B, Lee, N R, Lehtimäki, T, Lewis, C E, Li, H, Li, J, Li-Gao, R, Lin, H, Lin, K-H, Lin, L-A, Lin, X, Lind, L, Lindström, J, Linneberg, A, Liu, C-T, Liu, D J, Liu, Y, Lo, K S, Lophatananon, A, Lotery, A J, Loukola, A, Luan, JA, Lubitz, S A, Lyytikäinen, L-P, Männistö, S, Marenne, G, Mazul, A L, McCarthy, M I, McKean-Cowdin, R, Medland, S E, Meidtner, K, Milani, L, Mistry, V, Mitchell, P, Mohlke, K L, Moilanen, L, Moitry, M, Montgomery, G W, Mook-Kanamori, D O, Moore, C, Mori, T A, Morris, A D, Morris, A P, Müller-Nurasyid, M, Munroe, P B, Nalls, M A, Narisu, N, Nelson, C P, Neville, M, Nielsen, S F, Nikus, K, Njølstad, P L R, Nordestgaard, B R G, Nyholt, D R, O'Connel, J R, O'Donoghue, M L, Olde Loohuis, L M, Ophoff, R A, Owen, K R, Packard, C J, Padmanabhan, S, Palmer, C N A, Palmer, N D, Pasterkamp, G, Patel, A P, Pattie, A, Pedersen, O, Peissig, P L, Peloso, G M, Pennell, C E, Perola, M, Perry, J A, Perry, J R B, Pers, T H, Person, T N, Peters, A, Petersen, E R B, Peyser, P A, Pirie, A, Polasek, O, Polderman, T J, Puolijoki, H, Raitakari, O T, Rasheed, A, Rauramaa, R, Reilly, D F, Renström, F, Rheinberger, M, Ridker, P M, Rioux, J D, Rivas, M A, Roberts, D J, Robertson, N R, Robino, A, Rolandsson, O, Rudan, I, Ruth, K S, Saleheen, D, Salomaa, V, Samani, N J, Sapkota, Y, Sattar, N, Schoen, R E, Schreiner, P J, Schulze, M B, Scott, R A, Segura-Lepe, M P, Shah, S H, Sheu, W H-H, Sim, X, Slater, A J, Small, K S, Smith, A V, Southam, L, Spector, T D, Speliotes, E K, Starr, J M, Stefansson, K, Steinthorsdottir, V, Stirrups, K E, Strauch, K, Stringham, H M, Stumvoll, M, Sun, L, Surendran, P, Swift, A J, Tada, H, Tansey, K E, Tardif, J-C, Taylor, K D, Teumer, A, Thompson, D J, Thorleifsson, G, Thorsteinsdottir, U, Thuesen, B H, Tönjes, A, Tromp, G, Trompet, S, Tsafantakis, E, Tuomilehto, J, Tybjaerg-Hansen, A, Tyrer, J P, Uher, R, Uitterlinden, A G, Uusitupa, M, Laan, S W, Duijn, C M, Leeuwen, N, van Setten, J, Vanhala, M, Varbo, A, Varga, T V, Varma, R, Velez Edwards, D R, Vermeulen, S H, Veronesi, G, Vestergaard, H, Vitart, V, Vogt, T F, Völker, U, Vuckovic, D, Wagenknecht, L E, Walker, M, Wallentin, L, Wang, F, Wang, C A, Wang, S, Wang, Y, Ware, E B, Wareham, N J, Warren, H R, Waterworth, D M, Wessel, J, White, H D, Willer, C J, Wilson, J G, Witte, D R, Wood, A R, Wu, Y, Yaghootkar, H, Yao, J, Yao, P, Yerges-Armstrong, L M, Young, R, Zeggini, E, Zhan, X, Zhang, W, Zhao, J H, Zhao, W, Zhou, W, Zondervan, K T, Rotter, J I, Pospisilik, J A, Rivadeneira, F, Borecki, I B, Deloukas, P, Frayling, T M, Lettre, G, North, K E, Lindgren, C M, Hirschhorn, J N & Loos, R J F 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-35 . https://doi.org/10.1038/s41588-017-0011-x
Nature Genetics, 50(1), 26. Nature Publishing Group
Nature Genetics
Nat. Genet. 50, 26-41 (2018)
Nature genetics, 50(1), 26-41. Nature Publishing Group
Nature Genetics, 50(1), 26-41. Nature Publishing Group
Nature genetics, vol. 50, no. 1, pp. 26-41
Nature Genetics, 50(1), 26
NATURE GENETICS
Nature genetics 50(1), 26-41 (2017). doi:10.1038/s41588-017-0011-x
Nature Genetics, 50, 26-41
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Brandslund, I, Christensen, C, Jensen, G B, Jørgensen, M E, Thuesen, B H & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-018-0050-y
Nature Genetics, 50(1), 26-35. Nature Publishing Group
Nature Genetics, 50, 1, pp. 26-41
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247d0a0f65cfe65a4234fc1f8f72fc1d
https://doi.org/10.1038/s41588-017-0011-x
https://doi.org/10.1038/s41588-017-0011-x
Autor:
Laura Leonhardt, Tanya Vavouri, Chih-Hsiang Yang, Brad G. Hoffman, Tess Tsai Hsiu Lu, Ulrike Boenisch, Marius Ruf, Francis C. Lynn, Steffen Heyne, Laura Arrigoni, Thorina Boenke, Stuart H. Orkin, Huafeng Xie, Eduard Casas, Dominic Grün, Lennart Enders, Sunil Jayaramaiah Raja, Erez Dror, J. Andrew Pospisilik, Kevin Dalgaard, Sagar, Adelheid Lempradl, Madhan Selvaraj, Raffaele Teperino
Publikováno v:
Cell Metabolism
Cell Metab. 27, 1294-1308.e7 (2018)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Cell Metab. 27, 1294-1308.e7 (2018)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Summary To date, it remains largely unclear to what extent chromatin machinery contributes to the susceptibility and progression of complex diseases. Here, we combine deep epigenome mapping with single-cell transcriptomics to mine for evidence of chr