Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Adelheid Kratzer"'
Autor:
Harsha V. Renikunta, Katina Lazarow, Yiqi Gong, Praphulla Chandra Shukla, Vanasa Nageswaran, Hector Giral, Adelheid Kratzer, Lennart Opitz, Felix B. Engel, Arash Haghikia, Sarah Costantino, Francesco Paneni, Jens Peter von Kries, Katrin Streckfuss-Bömeke, Ulf Landmesser, Philipp Jakob
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106593- (2023)
Summary: Ischemic cardiomyopathy, driven by loss of cardiomyocytes and inadequate proliferative response, persists to be a major global health problem. Using a functional high-throughput screening, we assessed differential proliferative potential of
Externí odkaz:
https://doaj.org/article/0397c180ca2842079b4aa0e59e2381c0
Autor:
Hector Giral, Vedran Franke, Minoo Moobed, Maja F. Müller, Laura Lübking, Divya Maria James, Johannes Hartung, Kira Kuschnerus, Denitsa Meteva, Claudio Seppelt, Philipp Jakob, Roland Klingenberg, Nicolle Kränkel, David Leistner, Tanja Zeller, Stefan Blankenberg, Friederike Zimmermann, Arash Haghikia, Thomas F. Lüscher, Altuna Akalin, Ulf Landmesser, Adelheid Kratzer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Inflammasomes are crucial gatekeepers of the immune response, but their maladaptive activation associates with inflammatory pathologies. Besides canonical activation, monocytes can trigger non-transcriptional or rapid inflammasome activation that has
Externí odkaz:
https://doaj.org/article/83cde5d17281485182d722555e086e4e
Autor:
Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A. Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E. Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J. Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S. Leisegang, Jun Zhu, Ralf P. Brandes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolis
Externí odkaz:
https://doaj.org/article/4401176dc9754aceb3a9a13dbd4a3e34
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
Genome-wide association studies (GWAS) have proven a fundamental tool to identify common variants associated to complex traits, thus contributing to unveil the genetic components of human disease. Besides, the advent of GWAS contributed to expose une
Externí odkaz:
https://doaj.org/article/ed845c0a3da843228af93092396180b2
Autor:
Marlene Buchebner, Thomas Pfeifer, Nora Rathke, Prakash G. Chandak, Achim Lass, Renate Schreiber, Adelheid Kratzer, Robert Zimmermann, Wolfgang Sattler, Harald Koefeler, Eleonore Fröhlich, Gerhard M. Kostner, Ruth Birner-Gruenberger, Kyle P. Chiang, Guenter Haemmerle, Rudolf Zechner, Sanja Levak-Frank, Benjamin Cravatt, Dagmar Kratky
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 10, Pp 2896-2908 (2010)
Cholesteryl ester (CE) accumulation in macrophages represents a crucial event during foam cell formation, a hallmark of atherogenesis. Here we investigated the role of two previously described CE hydrolases, hormone-sensitive lipase (HSL) and KIAA136
Externí odkaz:
https://doaj.org/article/f9cd1796d8884eac8aad2126c35d20ff
Autor:
Ryan S. Lim, Adelheid Kratzer, Nicholas P. Barry, Shinobu Miyazaki-Anzai, Makoto Miyazaki, William W. Mantulin, Moshe Levi, Eric O. Potma, Bruce J. Tromberg
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 7, Pp 1729-1737 (2010)
We characterized several cellular and structural features of early stage Type II/III atherosclerotic plaques in an established model of atherosclerosis—the ApoE-deficient mouse—by using a multimodal, coregistered imaging system that integrates th
Externí odkaz:
https://doaj.org/article/34dff783e53c463da93d61042bc70185
Autor:
Adelheid Kratzer, Marlene Buchebner, Thomas Pfeifer, Tatjana M. Becker, Georg Uray, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Birgit Ebner, Prakash G. Chandak, Rajendra S. Kadam, Emine Calayir, Nora Rathke, Helmut Ahammer, Branislav Radovic, Michael Trauner, Gerald Hoefler, Uday B. Kompella, Guenter Fauler, Moshe Levi, Sanja Levak-Frank, Gerhard M. Kostner, Dagmar Kratky
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 2, Pp 312-326 (2009)
Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism. LXR agonists have been shown to limit the cellular cholesterol content by inducing reverse cholesterol transport, increasing bile acid production, and inhibiting i
Externí odkaz:
https://doaj.org/article/6a1e1a9cda944a8a9646f076b4b3f93a
Autor:
Rafael R. C. Cuadrat, Adelheid Kratzer, Hector Giral Arnal, Katarzyna Wreczycka, Alexander Blume, Veronika Ebenal, Tiina Mauno, Brendan Osberg, Minoo Moobed, Johannes Hartung, Claudio Seppelt, Denitsa Meteva, Arash Haghikia, David Leistner, Ulf Landmesser, Altuna Akalin
Acute coronary syndromes (ACS) remain a major cause of worldwide mortality. ACS diagnosis is done by a combination of factors, such as electrocardiogram and plasma biomarkers. These biomarkers, however, lack the power to accurately stratify patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68557acd7aaeb10916fda9097f75e3c7
https://doi.org/10.1101/2021.11.05.21265870
https://doi.org/10.1101/2021.11.05.21265870
Autor:
Daniela Börnigen, Bernhard H. Rauch, Christian P. Müller, Tetsuro Hirose, Adelheid Kratzer, Benjamin Meder, Arash Haghikia, Andrea Stroux, Lars Riff Jensen, Anja A. Kühl, Nicolle Kraenkel, Andreas W. Kuss, David Schmidt, Tanja Zeller, Shinichi Nakagawa, Stefan Blankenberg, Felicitas Escher, Paul Schumann, Jan Haas, Stefan Weiss, Martina Gast, Ulf Landmesser, Wolfgang Poller
Publikováno v:
Cardiovascular Research. 115:1886-1906
AimsInflammation is a key driver of atherosclerosis and myocardial infarction (MI), and beyond proteins and microRNAs (miRs), long noncoding RNAs (lncRNAs) have been implicated in inflammation control. To obtain further information on the possible ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dde6d590d674092c7346ce435a284e6
https://doi.org/10.1093/cvr/cvz085
https://doi.org/10.1093/cvr/cvz085
Publikováno v:
European Heart Journal. 41
Background Acute inflammation leads to increased myelopoiesis in the bone marrow and recruitment of immune cells to respective sites of injury. Yet, in certain cases of high demand such as acute tissue damage as in acute myocardial infarction (AMI),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e06536f2c51e99545ac76c25a12e140
https://doi.org/10.1093/ehjci/ehaa946.3726
https://doi.org/10.1093/ehjci/ehaa946.3726