Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Adelfa E Serrano"'
Autor:
Joel Vega-Rodríguez, Rebecca Pastrana-Mena, Keila N Crespo-Lladó, José G Ortiz, Iván Ferrer-Rodríguez, Adelfa E Serrano
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128212 (2015)
Malaria is one of the most devastating parasitic diseases worldwide. Plasmodium drug resistance remains a major challenge to malaria control and has led to the re-emergence of the disease. Chloroquine (CQ) and artemisinin (ART) are thought to exert t
Externí odkaz:
https://doaj.org/article/f7eb486b4c66480788295d76f55c2d1b
Autor:
Joel Vega-Rodríguez, Blandine Franke-Fayard, Rhoel R Dinglasan, Chris J Janse, Rebecca Pastrana-Mena, Andrew P Waters, Isabelle Coppens, José F Rodríguez-Orengo, Prakash Srinivasan, Marcelo Jacobs-Lorena, Adelfa E Serrano
Publikováno v:
PLoS Pathogens, Vol 5, Iss 2, p e1000302 (2009)
Infection of red blood cells (RBC) subjects the malaria parasite to oxidative stress. Therefore, efficient antioxidant and redox systems are required to prevent damage by reactive oxygen species. Plasmodium spp. have thioredoxin and glutathione (GSH)
Externí odkaz:
https://doaj.org/article/425bfba860d9447ba5c84dcefa36255b
Publikováno v:
Life, Vol 14, Iss 6, p 684 (2024)
Plakortinic acids C (1) and D (2), an unseparable pair of endoperoxide polyketides isolated and purified from the symbiotic association of Caribbean Sea sponges Plakortis symbiotica-Xestospongia deweerdtae, underwent in vitro evaluation for antiplasm
Externí odkaz:
https://doaj.org/article/58db61bc0e4f4d9e8bf9d67b1f36adb1
Autor:
Luis A. Amador, Abimael D. Rodríguez, Lesly Carmona-Sarabia, Emilee E. Colón-Lorenzo, Adelfa E. Serrano
Publikováno v:
Applied Sciences, Vol 14, Iss 1, p 281 (2023)
Gracilioether M (6) and 11,12-dihydrogracilioether M (7), two polyketides with a [2(5H)-furanylidene]ethanoate moiety, along with known plakortone G (9) and its new naturally occurring derivative 9,10-dihydroplakortone G (8), were isolated from the C
Externí odkaz:
https://doaj.org/article/50f2e052fbe84ec9b7a207a714a58c38
Autor:
Abiel Roche-Lima, Angélica M. Rosado-Quiñones, María Del Mar Figueroa-Gispert, Jennifer Díaz-Rivera, Roberto G. Díaz-González, Kelvin Carrasquillo-Carrion, Roberto A. Feliu-Maldonado, Pedro Fernández-Gochez, Brenda G. Nieves-Rodríguez, Emilee E. Colón-Lorenzo, Adelfa E. Serrano
Antimicrobial and antiviral resistances are worldwide public health threats, causing treatment failures and increasing morbidity and mortality. Mycobacterium tuberculosis and Plasmodium falciparum, among many others, are examples of multidrug-resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e856657b4b194ff0770cbe95c5326b78
https://doi.org/10.21203/rs.3.rs-1789485/v1
https://doi.org/10.21203/rs.3.rs-1789485/v1
Autor:
Emilee E. Colón-Lorenzo, Daisy D. Colón-López, Joel Vega-Rodríguez, Alice Dupin, David A. Fidock, Abel Baerga-Ortiz, José G. Ortiz, Jürgen Bosch, Adelfa E. Serrano
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Plasmodium falciparum parasites are increasingly drug-resistant, requiring the search for novel antimalarials with distinct modes of action. Enzymes in the glutathione pathway, including glutathione S-transferase (GST), show promise as novel antimala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bc682d52de1423ecb36ab3797e5fc2
https://www.frontiersin.org/article/10.3389/fphar.2020.00246/full
https://www.frontiersin.org/article/10.3389/fphar.2020.00246/full
Autor:
Emilee E, Colón-Lorenzo, Daisy D, Colón-López, Joel, Vega-Rodríguez, Alice, Dupin, David A, Fidock, Abel, Baerga-Ortiz, José G, Ortiz, Jürgen, Bosch, Adelfa E, Serrano
Publikováno v:
Frontiers in Pharmacology
Plasmodium falciparum parasites are increasingly drug-resistant, requiring the search for novel antimalarials with distinct modes of action. Enzymes in the glutathione pathway, including glutathione S-transferase (GST), show promise as novel antimala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::470a4f0baaafad887fd7fb116386d8f2
https://pubmed.ncbi.nlm.nih.gov/32256353
https://pubmed.ncbi.nlm.nih.gov/32256353
Publikováno v:
The Yale Journal of Biology and Medicine
Endothelial abnormalities play a critical role in the pathogenesis of malaria caused by the human pathogen, Plasmodium falciparum. In serious infections and especially in cerebral malaria, red blood cells infected with the parasite are sequestered in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd8e9691880ec4de7b30e2af5f9c1441
https://pubmed.ncbi.nlm.nih.gov/28656007
https://pubmed.ncbi.nlm.nih.gov/28656007
Autor:
Daniela Masi, Keila N. Crespo-Llado, Amanda K. Lukens, Roger C. Wiegand, Dyann F. Wirth, Ann Rowley, Jeremy R. Duvall, Richard W. Heidebrecht, Mark E. Fitzgerald, Michael Foley, Adelfa E. Serrano, Nobutaka Kato, Stuart L. Schreiber, Marion Mercier, Benito Munoz, Carol A. Mulrooney, Christina Scherer, Eamon Comer, Maurice D. Lee, Michelle Palmer, Giovanni Muncipinto, Jennifer A. Beaudoin
Publikováno v:
Journal of Medicinal Chemistry
Here, we describe medicinal chemistry that was accelerated by a diversity-oriented synthesis (DOS) pathway, and in vivo studies of our previously reported macrocyclic antimalarial agent that derived from the synthetic pathway. Structure–activity re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0a1ed1bf52387b6cc5aab71452f65c
http://europepmc.org/articles/PMC4207553
http://europepmc.org/articles/PMC4207553
Autor:
Xavier Fernàndez-Busquets, Patricia Urbán, Robert H. Barker, Anne Grobler, Pieter Buys Burger, Lyn-Marie Birkholtz, Jandeli Niemand, Dina Le Roux, Abraham I. Louw, Adelfa E. Serrano
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
Graphical abstract
Highlights • A highly specific inhibitor, Genz-644131, was identified for P. falciparum AdoMetDC. • Increased specificity for bifunctional over monofunctional PfAdoMetDC was shown. • Genz-644131 showed improved inhibitio
Highlights • A highly specific inhibitor, Genz-644131, was identified for P. falciparum AdoMetDC. • Increased specificity for bifunctional over monofunctional PfAdoMetDC was shown. • Genz-644131 showed improved inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375e237fa73d58e8edbfb5aae147f99b
http://europepmc.org/articles/PMC3940083
http://europepmc.org/articles/PMC3940083