Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Adeleke H Aguda"'
Autor:
Simon Law, Preety Panwar, Jody Li, Adeleke H Aguda, Andrew Jamroz, Rafael V C Guido, Dieter Brömme
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186869 (2017)
Cathepsin K (CatK) is a cysteine protease that plays an important role in mammalian intra- and extracellular protein turnover and is known for its unique and potent collagenase activity. Through studies on the mechanism of its collagenase activity, s
Externí odkaz:
https://doaj.org/article/b8e1c750eb84499aa628571486395374
Autor:
Vivian Wing Ngar Cheung, Bo Xue, Maria Hernandez-Valladares, Maybelle Kho Go, Alvin Tung, Adeleke H Aguda, Robert C Robinson, Wen Shan Yew
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103598 (2014)
Due to the emergence of resistance toward current antibiotics, there is a pressing need to develop the next generation of antibiotics as therapeutics against infectious and opportunistic diseases of microbial origins. The shikimate pathway is exclusi
Externí odkaz:
https://doaj.org/article/89322fbd3c1149c8a87ecc325ad9f878
Autor:
Christina Tysoe, Leslie K. Williams, Robert Keyzers, Nham T. Nguyen, Chris Tarling, Jacqueline Wicki, Ethan D. Goddard-Borger, Adeleke H. Aguda, Suzanne Perry, Leonard J. Foster, Raymond J. Andersen, Gary D. Brayer, Stephen G. Withers
Publikováno v:
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)
Externí odkaz:
https://doaj.org/article/ba205bf08fcc4bb4a7ca9db931de6034
Autor:
Fuqiang Ban, Evgenia V. Dueva, Takeshi Yamazaki, Nada Lallous, Nader Al Nakouzi, Martin E. Gleave, Amina Zoubeidi, Susan C. Moore, Nham T. Nguyen, Fan Zhang, Neetu Saxena, Sophie M. Stief, Lucia Nappi, Dulguun Battsogt, Eliana Beraldi, Marisa Thi, Barbara Lelj-Garolla, Artem Cherkasov, Adeleke H Aguda, Gary D. Brayer, Ladan Fazli
Publikováno v:
J Clin Invest
HSP27 is highly expressed in, and supports oncogene addiction of, many cancers. HSP27 phosphorylation is a limiting step for activation of this protein and a target for inhibition, but its highly disordered structure challenges rational structure-gui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e7e5717c173cfc68e7cf7ebb1f87e5
https://pubmed.ncbi.nlm.nih.gov/31845908
https://pubmed.ncbi.nlm.nih.gov/31845908
Autor:
Amina Zoubeidi, Soojin Kim, Olena Sivak, Ravi Shashi Nayana Munuganti, Adeleke H Aguda, Daksh Thaper, Sepideh Vahid, Himisha Beltran, Loredana Puca, Sahil Kumar, Shaghayegh Nouruzi
Publikováno v:
Journal of Clinical Oncology. 37:260-260
260 Background: Resistance to newly developed androgen receptor pathway inhibitors (ARPIs), such as Enzalutamide (ENZ), rapidly emerges and patients generally die within two years. In particular, a subset of patients who relapse following ARPI therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6f827650c1bdaed0ed3e345adf88904
https://doi.org/10.1200/jco.2019.37.7_suppl.260
https://doi.org/10.1200/jco.2019.37.7_suppl.260
Autor:
Alvin Tung, John A. Cooper, Balakrishnan Kannan, Robert Robinson, Maria Hernandez-Valladares, Taekyung Kim, Adeleke H. Aguda, Mårten Larsson
Publikováno v:
Nature Structural & Molecular Biology. 17:497-503
Capping protein (CP) regulates actin dynamics by binding the barbed ends of actin filaments. Removal of CP may be one means to harness actin polymerization for processes such as cell movement and endocytosis. Here we structurally and biochemically in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373e4cf7e9feb640998da41f055e92f7
https://doi.org/10.1038/nsmb.1792
https://doi.org/10.1038/nsmb.1792
Publikováno v:
Annals of the New York Academy of Sciences. 1112:56-66
In recent years two structures have been reported that demonstrate how the two halves of a beta-thymosin repeat bind to actin monomers. Here we assess the validity of these structures and construct minimally biased models of the beta-thymosin:actin c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd8ef8c962acad1fc3218b84db205cb
https://doi.org/10.1196/annals.1415.010
https://doi.org/10.1196/annals.1415.010
Publikováno v:
EMBO reports. 6:220-226
Movement is a defining characteristic of life. Macroscopic motion is driven by the dynamic interactions of myosin with actin filaments in muscle. Directed polymerization of actin behind the advancing membrane of a eukaryotic cell generates microscopi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fc246843cb5403ee85e1b092d7661a
https://doi.org/10.1038/sj.embor.7400363
https://doi.org/10.1038/sj.embor.7400363
Autor:
Christophe Guérin, Laurent Blanchoin, Robert Robinson, Helen L. Yin, Adeleke H. Aguda, Leslie D. Burtnick, Mårten Larsson, Edward Irobi
Publikováno v:
The EMBO Journal. 23:3599-3608
The WH2 (Wiscott-Aldridge syndrome protein homology domain 2) repeat is an actin interacting motif found in monomer sequestering and filament assembly proteins. We have stabilized the prototypical WH2 family member, thymosin-beta4 (Tbeta4), with resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172c7c128a513c1cffeee390f64660de
https://doi.org/10.1038/sj.emboj.7600372
https://doi.org/10.1038/sj.emboj.7600372
Autor:
Robert Robinson, Supansa Pantoom, Wipa Suginta, Chomphunuch Songsiriritthigul, Adeleke H. Aguda
Publikováno v:
Journal of structural biology. 162(3)
This research describes four X-ray structures of Vibrio harveyi chitinase A and its catalytically inactive mutant (E315M) in the presence and absence of substrates. The overall structure of chitinase A is that of a typical family-18 glycosyl hydrolas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586ea5da743947c74dd188c7b60c4bef
https://pubmed.ncbi.nlm.nih.gov/18467126
https://pubmed.ncbi.nlm.nih.gov/18467126