Výsledky vyhledávání - "Adeleke Aguda"

Akademický článek

ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer

Autor: Shaghayegh Nouruzi, Dwaipayan Ganguli, Nakisa Tabrizian, Maxim Kobelev, Olena Sivak, Takeshi Namekawa, Daksh Thaper, Sylvan C. Baca, Matthew L. Freedman, Adeleke Aguda, Alastair Davies, Amina Zoubeidi

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Following androgen receptor pathway inhibition prostate cancers can differentiate towards the neuroendocrine lineage. Here, the authors identify epigenetic alterations regulated by ASCL1 and suggest targeting ASCL1 to reverse the neuroendocrine pheno

Externí odkaz: https://doaj.org/article/d4c48d0f84e74da9bf7129acd29bbc7f

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Discovery and characterization of a first-in-field transcription factor BRN2 inhibitor for the treatment of neuroendocrine prostate cancer

Autor: Daksh Thaper, Ravi Munuganti, Adeleke Aguda, Soojin Kim, Shengyu Ku, Olena Sivak, Sahil Kumar, Sepideh Vahid, Dwaipayan Ganguli, Himisha Beltran, Colm Morrissey, Eva Corey, Amina Zoubeidi

The increased incidence of treatment-emergent neuroendocrine prostate cancer (NEPC) is particularly alarming as this diagnosis is associated with poor prognosis. Despite initial responses to platinum-based chemotherapy, relapses are common and there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9375bc995eb9f52938f4d924e18dc2eb
https://doi.org/10.1101/2022.05.04.490172

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ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer

Publikováno v: Nature communications. 13(1)

Treatment with androgen receptor pathway inhibitors (ARPIs) in prostate cancer leads to the emergence of resistant tumors characterized by lineage plasticity and differentiation toward neuroendocrine lineage. Here, we find that ARPIs induce a rapid e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306534f1fecfdbadad72f0794b811388
https://pubmed.ncbi.nlm.nih.gov/35477723

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Potent Human α-Amylase Inhibition by the β-Defensin-like Protein Helianthamide

Autor: Adeleke Aguda, Leonard J. Foster, Jacqueline Wicki, Ethan D. Goddard-Borger, Gary D. Brayer, Christina Tysoe, Robert A. Keyzers, Stephen G. Withers, Leslie K. Williams, Nham T. Nguyen, Raymond J. Andersen, Suzanne Perry, Chris A. Tarling

Publikováno v: ACS Central Science
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)

Selective inhibitors of human pancreatic α-amylase (HPA) are an effective means of controlling blood sugar levels in the management of diabetes. A high-throughput screen of marine natural product extracts led to the identification of a potent (Ki =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2203587f5c05ee5fe8629b52e661e5
http://europepmc.org/articles/PMC4819454

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Abstract 3083: Selective inhibition of transcription factor BRN2 as a treatment strategy for Small Cell Prostate Cancer

Autor: Amina Zoubeidi, Soo Jin Kim, Shungyu Ku, Olena Sivak, Sahil Kumar, Daksh Thaper, Shaghayegh Nouruzi, Adeleke Aguda, Ravi Shashi Nayana Munuganti, Dwaiyapan Ganguli, Eva Corey, Colm Morrissey, Himisha Beltran, Sepideh Vahid

Publikováno v: Cancer Research. 80:3083-3083

Introduction: Resistance to newly developed androgen receptor pathway inhibitors (ARPIs), such as Enzalutamide (ENZ), rapidly emerges. In particular, a subset of patients who relapse following ARPI therapy their dependence on AR signaling and emerge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::805fd2dadefed0dff42408c0e658b3b2
https://doi.org/10.1158/1538-7445.am2020-3083

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Abstract 14: Computer-aided discovery of small-molecule inhibitors targeting neural transcription factor BRN2 in neuroendocrine prostate tumors

Autor: Soojin Kim, Amina Zoubeidi, Adeleke Aguda, Daksh Thaper, Ravi Shashi Nayana Munuganti, Olena Sivak

Publikováno v: Clinical Cancer Research. 26:14-14

Therapies targeting tumor-fueling androgens have been mainstay treatments of advanced prostate cancer for almost 5 decades. While the androgen receptor (AR) inhibitor enzalutamide (ENZ) prolongs survival of castration-resistant prostate cancer patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ae9f559bc623432cf16912631903aeb
https://doi.org/10.1158/1557-3265.advprecmed20-14

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Abstract 1295: First-in-field small molecule inhibitors targeting BRN2 as a therapeutic strategy for small cell prostate cancer

Autor: Daksh Thaper, Ravi Munuganti, Shaghayegh Nouruzi, Sahil Kumar, Soojin Kim, Olena Sivak, Adeleke Aguda, Dwaipayan Ganguli, Sepideh Vahid, Loredana Puca, Himisha Beltran, Amina Zoubeidi

Publikováno v: Cancer Research. 79:1295-1295

Introduction: Resistance to newly developed androgen receptor pathway inhibitors (ARPIs), such as Enzalutamide (ENZ), rapidly emerges and patients generally die within two years. In particular, a subset of patients who relapse following ARPI therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62abcfb0fb4bd3f79954c6fd19d6dec8
https://doi.org/10.1158/1538-7445.am2019-1295

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Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib

Autor: Natasha Kruglyak, Simon Law, Nham T. Nguyen, Pierre-Marie Andrault, Adeleke Aguda, Gary D. Brayer, Dieter Brömme

Publikováno v: The Biochemical journal. 474(5)

Cathepsin K (CatK) is the predominant mammalian bone-degrading protease and thus an ideal target for antiosteoporotic drug development. Rodent models of osteoporosis are preferred due to their close reflection of the human disease and their ease of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528f8124f48a3617ed134c2be566f2bf
https://pubmed.ncbi.nlm.nih.gov/28049758

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Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts

Autor: Gary D. Brayer, Labros G. Meimetis, Ping Cheng, Ivan Villanueva, Tina M. Bott, Simon Law, Dieter Brömme, Adeleke Aguda, Vincent Lavallee, Nham T. Nguyen, Jadwiga Kaleta, David E. Williams, Julian Davies, Raymond J. Andersen

Publikováno v: Journal of natural products. 79(8)

Natural products are an important source of novel drug scaffolds. The highly variable and unpredictable timelines associated with isolating novel compounds and elucidating their structures have led to the demise of exploring natural product extract l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c6b78745cc35ab87747ee908c4cd3d
https://pubmed.ncbi.nlm.nih.gov/27498895

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A composite docking approach for the identification and characterization of ectosteric inhibitors of cathepsin K

Autor: Jody Li, Preety Panwar, Andrew Jamroz, Rafael Victorio Carvalho Guido, Simon Law, Adeleke Aguda, Dieter Brömme

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0186869 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE

Cathepsin K (CatK) is a cysteine protease that plays an important role in mammalian intra- and extracellular protein turnover and is known for its unique and potent collagenase activity. Through studies on the mechanism of its collagenase activity, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8aa7653b85a6e70b46cb708d7217fbf
https://doi.org/10.1371/journal.pone.0186869

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