Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Adelekan Oyejide"'
Autor:
Jie Gao, Shumei Ren, Gabrielle Choonoo, Guoying Chen, Davor Frleta, Jun Zhong, Namita Gupta, Prachi Sharma, Adelekan Oyejide, Gurinder S. Atwal, Lynn Macdonald, Andrew Murphy, Frank Kuhnert
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/f34fbf216179435187f79c76d754a080
Autor:
Audrey Le Floc’h, Kirsten Nagashima, Dylan Birchard, George Scott, Li-Hong Ben, Dharani Ajithdoss, Kaitlyn Gayvert, Annabel Romero Hernandez, Olivier Herbin, Amanda Tay, Pamela Farrales, Chandrashekhar K. Korgaonkar, Hao Pan, Sweta Shah, Vishal Kamat, Ishita Chatterjee, Jon Popke, Adelekan Oyejide, Wei Keat Lim, Jee H. Kim, Tammy Huang, Matthew Franklin, William Olson, Thomas Norton, Lorah Perlee, George D. Yancopoulos, Andrew J. Murphy, Matthew A. Sleeman, Jamie M. Orengo
Publikováno v:
Science Translational Medicine. 15
The common γ chain (γc; IL-2RG) is a subunit of the interleukin (IL) receptors for the γc cytokines IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The lack of appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to thoroughly in
Autor:
George Scott, Seblewongel Asrat, Jeanne Allinne, Wei Keat Lim, Kirsten Nagashima, Dylan Birchard, Subhashini Srivatsan, Dharani K. Ajithdoss, Adelekan Oyejide, Li-Hong Ben, Johnathon Walls, Audrey Le Floc'h, George D. Yancopoulos, Andrew J. Murphy, Matthew A. Sleeman, Jamie M. Orengo
Publikováno v:
Cytokine. 162:156091
Type 2 (T2) asthma is characterized by airflow limitations and elevated levels of blood and sputum eosinophils, fractional exhaled nitric oxide, IgE, and periostin. While eosinophils are associated with exacerbations, the contribution of eosinophils
Autor:
Min Ni, Anbo Zhou, Tammy Taylor, Mark G. Lewis, Anthony L. Cook, Maciel Porto, Olga Gonzalez, Neil Stahl, Adelekan Oyejide, Laurent Pessaint, Dharani Ajithdoss, John Dutton, Jack Greenhouse, Kendra J. Alfson, Edward J. Dick, Kathryn Lanza, Richard Copin, Christos A. Kyratsous, Bret J Musser, Kusha Mohammadi, Ricardo Carrion, Vaneesha Ali, Elizabeth Clemmons, Michal Gazi, George D. Yancopoulos, Nicole Negron, Hilary M. Staples, Hanne Leth Andersen, Gurinder S. Atwal, Alina Baum, Andrew J. Murphy, Renita Brown, Yenny Goez-Gazi, Yi Wei, Carmen Bartley, Benjamin Klaffke
Publikováno v:
Science
Science (New York, N.y.)
Science (New York, N.y.)
A beneficial cocktail Since the start of the coronavirus disease 2019 (COVID-19) pandemic, considerable effort has gone into generating and characterizing neutralizing antibodies that could be used as therapeutics. Studies in humanized mice and conva
Autor:
Lori G Morton, Adelekan Oyejide, Qian Zhang, Li Pan, David J. Glass, Sara Hamon, Jianing Xu, Anita Boyapati, Dharani Ajithdoss, Tea Shavlakadze, Christos A. Kyratsous, Matthew F. Wipperman, Matthew Wakai, Raphael Simonson, Megan McAleavy, Abhilash Gadi, Peter J. Ehmann
Publikováno v:
Molecular and Cellular Biology
A subset of hospitalized COVID-19 patients, particularly the aged and those with comorbidities, develop the most severe form of the disease, characterized by acute respiratory disease syndrome (ARDS), coincident with experiencing a “cytokine storm.
Autor:
Adelekan Oyejide, Seblewongel Asrat, Dharani Ajithdoss, Jeanne Allinne, George Scott, Wei Keat Lim, Johnathon R. Walls, Li-Hong Ben, Kirsten Nagashima, Matthew A. Sleeman, Subhashini Srivatsan, Andrew J. Murphy, Jamie M. Orengo, Audrey Le Floc’h, Dylan Birchard, George D. Yancopoulos
Publikováno v:
Molecular pathology and functional genomics.
Autor:
Justin Ferdin, Vida L. Hodara, Dhiraj Kumar Singh, Shalini Gautam, Shabaana A. Khader, Shannan Hall-Ursone, Shashank Ganatra, Yenny Goez-Gazi, Tae-Hyung Lee, Benjamin Klaffke, Riti Sharan, Elizabeth Clemmons, Cynthia Alvarez, Olga Gonzalez, Christopher H. Chen, Kathleen M. Brasky, Laura M. Parodi, Kendra J. Alfson, Rajesh Thippeshappa, Alyssa Schami, Joanne Turner, Richard Copin, Andra K. Voges, Angélica Olmo-Fontánez, Makedonka Mitreva, Michal Gazi, Amanda Mannino, Patrice A. Frost, Ruby Escobedo, Alyssa Blakley, Deepak Kaushal, Edward J. Dick, Julia M. Scordo, Dharani Ajithdoss, John Dutton, Journey Cole, Hilary M. Staples, Christos A. Kyratsous, Priscilla Escareno, Luis D. Giavedoni, Ricardo Carrion, Bruce A. Rosa, Maya Gough, Luis Martinez-Sobrido, Mushtaq Ahmed, Bindu Singh, Roy N. Platt, Cory R. A. Hallam, Ken Sayers, Jessica Callery, Jordi B. Torrelles, Adelekan Oyejide, Jean L. Patterson, Andreu G. Vilanova, Carmen Bartley, Tim J. Anderson, Xavier Alvarez, Anna Goodroe, Larry S. Schlesinger, Corinna N. Ross, Alina Baum, Ayan Chatterjee
Publikováno v:
Nature Microbiology
Non-human primate models will expedite therapeutics and vaccines for coronavirus disease 2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in young and old rhesus macaque
REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters
Autor:
Vaneesha Ali, Adelekan Oyejide, Min Ni, Maciel Porto, Hilary M. Staples, Hanne Leth Andersen, Elizabeth Clemmons, George D. Yancopoulos, Nicole Negron, Benjamin Klaffke, Alina Baum, Renita Brown, Richard Copin, Neil Stahl, Yenny Goez-Gazi, Kendra J. Alfson, Gurinder S. Atwal, Yi Wei, Jack Greenhouse, Laurent Pessaint, Michal Gazi, Andrew J. Murphy, Mark G. Lewis, Dharani Ajithdoss, John Dutton, Anthony L. Cook, Carmen Bartley, Christos A. Kyratsous, Kathryn Lanza, Ricardo Carrion, Olga Gonzales, Edward J. Dick, Anbo Zhou, Tammy Taylor
An urgent global quest for effective therapies to prevent and treat COVID-19 disease is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10933) targeting non-overlapping epitopes on the SARS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80d7a5db0edff1dce694524bddc7a230
https://doi.org/10.1101/2020.08.02.233320
https://doi.org/10.1101/2020.08.02.233320
Autor:
Mushtaq Ahmed, Bindu Singh, Tim J. Anderson, Justin Ferdin, Shannan Hall-Ursone, Ruby Escabedo, Jean L. Patterson, Larry S. Schlesinger, Xavier Alvarez, Dhiraj Kumar Singh, Cory R. A. Hallam, Alina Baum, Michal Gazi, Bruce A. Rosa, Ken Sayers, Andra K. Voges, Corinna N. Ross, Jessica Callery, Amanda Mannino, Adelekan Oyejide, Carmen Bartley, Yenny Goez-Gazi, Ayan Chatterjee, Elizabeth Clemmons, Deepak Kaushal, Rajesh Thippeshappa, Cynthia Alvarez, Richard Copin, Tae-Hyung Lee, Edward J. Dick, Anna Goodroe, Hilary M. Staples, Christopher H. Chen, Julia M. Scordo, Journey Cole, Vida L. Hodara, Laura M. Parodi, Alyssa Blakely, Patrice A. Frost, Priscilla Escareno, Jordi B. Torrelles, Roy N. Platt, Riti Sharan, Benjamin Klaffke, Kendra J. Alfson, Olga Gonzalez, Shashank Ganatra, Makedonka Mitreva, Dharani Ajithdoss, John Dutton, Christos A. Kyratsous, Ricardo Carrion, Maya Gough, Luis Martinez-Sobrido, Shabaana A. Khader, Kathleen M. Brasky, Joanne Turner, Luis D. Giavedoni
SummaryThere are no known cures or vaccines for COVID-19, the defining pandemic of this era. Animal models are essential to fast track new interventions and nonhuman primate (NHP) models of other infectious diseases have proven extremely valuable. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d413a8dcc19ee3e0c2687e656a5356
https://doi.org/10.1101/2020.06.05.136481
https://doi.org/10.1101/2020.06.05.136481
Autor:
Drew Dudgeon, Xuan Ye, Jacqueline J. Warsaw, Evan Herlihy, Erica Ullman, Arpita Pawashe, William Poueymirou, Patrick Poon, Ilyssa Ramos, Dharani Ajithdoss, Bei Wang, Jacquelynn Golubov, Nicole Stokes Oristian, Eric Smith, Matthew A. Sleeman, George D. Yancopoulos, Rabih Slim, Alison Crawford, Priyanka Ram, William C. Olson, Chia-Jen Siao, Andrew J. Murphy, Hassan Ahmed, Terra Potocky, Janelle C. Waite, Danica Chiu, Gavin Thurston, Dimitris Skokos, Tammy T. Huang, Erin Oswald, Lauren Canova, Adelekan Oyejide, Stephen Godin, Lauren Havel, Kathleen Provoncha, Qi Wu, Douglas MacDonald, Miguel Lazo, Kevin Yu, Joel H. Martin, Ashique Rafique, Kristin Vazzana, John C. Lin, Lauric Haber, Jessica R. Kirshner, Aynur Hermann, Julie Kim
Publikováno v:
Science Translational Medicine. 12
T cell activation is initiated upon binding of the T cell receptor (TCR)/CD3 complex to peptide-major histocompatibility complexes ("signal 1"); activation is enhanced by engagement of a second "costimulatory" receptor, such as the CD28 receptor on T