Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Adele Woodhouse"'
Autor:
Brandon Signal, Andrew J. Phipps, Katherine A. Giles, Shannon N. Huskins, Timothy R. Mercer, Mark D. Robinson, Adele Woodhouse, Phillippa C. Taberlay
Publikováno v:
Cells, Vol 13, Iss 16, p 1393 (2024)
Neurons are central to lifelong learning and memory, but ageing disrupts their morphology and function, leading to cognitive decline. Although epigenetic mechanisms are known to play crucial roles in learning and memory, neuron-specific genome-wide e
Externí odkaz:
https://doaj.org/article/c459c9a294674a05900fa3cd372b4939
Autor:
Marcus S. Dyer, G. Lorenzo Odierna, Rosemary M. Clark, Adele Woodhouse, Catherine A. Blizzard
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Amyotrophic Lateral Sclerosis (ALS) is an incurable disease characterized by relentlessly progressive degeneration of the corticomotor system. Cortical hyperexcitability has been identified as an early pre-symptomatic biomarker of ALS. This suggests
Externí odkaz:
https://doaj.org/article/a373b867b43d4c239e7494e29d163436
Publikováno v:
Neurobiology of Disease, Vol 186, Iss , Pp 106284- (2023)
Different cell types in the brain play distinct roles in Alzheimer's disease (AD) progression. Late onset AD (LOAD) is a complex disease, with a large genetic component, but many risk loci fall in non-coding genome regions. Epigenetics implicates the
Externí odkaz:
https://doaj.org/article/2f380804260e4b8a8dccb1dab6284df2
Autor:
Adele Woodhouse, Carmen Maria Fernandez-Martos, Rachel Alice Kathryn Atkinson, Kelsey Anne Hanson, Jessica Marie Collins, Aidan Ryan O’Mara, Nico Terblanche, Marcus Welby Skinner, James Clement Vickers, Anna Elizabeth King
Publikováno v:
BMC Anesthesiology, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background There is increasing interest in whether anesthetic agents affect the risk or progression of Alzheimer’s disease (AD). To mitigate many of the methodological issues encountered in human retrospective cohort studies we have used a
Externí odkaz:
https://doaj.org/article/9d31865b280e468a93007bf83d1b1f0f
Publikováno v:
Brain Sciences, Vol 11, Iss 7, p 883 (2021)
Amyotrophic lateral sclerosis (ALS) is defined by the destruction of upper- and lower motor neurons. Post-mortem, nearly all ALS cases are positive for cytoplasmic aggregates containing the DNA/RNA binding protein TDP-43. Recent studies indicate that
Externí odkaz:
https://doaj.org/article/dc5d963691b340b8840cbb46785264f2
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
There is increasing interest in the role of epigenetic alterations in Alzheimer’s disease (AD). The epigenome of every cell type is distinct, yet data regarding epigenetic change in specific cell types in aging and AD is limited. We investigated hi
Externí odkaz:
https://doaj.org/article/eae4d5bdd54d4f929aa040d198af9d8d
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 2, Pp 323-333 (2006)
Apoptotic-like changes in the neocortex of control, pathologically aged and Alzheimer's disease (AD) cases were investigated. There was no increase in labeling or change in localization of labeling that distinguished between these cases for active ca
Externí odkaz:
https://doaj.org/article/f8c7fb3e2ee14fe0961a573201de2411
Publikováno v:
eLife, Vol 3 (2014)
Neurons have complex electrophysiological properties, however, it is often difficult to determine which properties are the most relevant to neuronal function. By combining current-clamp measurements of electrophysiological properties with multi-varia
Externí odkaz:
https://doaj.org/article/0c8a55d024b54e2ba2e89d691a4ad14c
Autor:
Roger S Chung, Claire Howells, Emma D Eaton, Lana Shabala, Kairit Zovo, Peep Palumaa, Rannar Sillard, Adele Woodhouse, William R Bennett, Shannon Ray, James C Vickers, Adrian K West
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12030 (2010)
BACKGROUND: A major pathological hallmark of AD is the deposition of insoluble extracellular beta-amyloid (Abeta) plaques. There are compelling data suggesting that Abeta aggregation is catalysed by reaction with the metals zinc and copper. METHODOLO
Externí odkaz:
https://doaj.org/article/b844c4b59b574b3c8779ab2d2108c6ba
Autor:
Laura A. Reale, Marcus S. Dyer, Sharn E. Perry, Kaylene M. Young, Tracey C. Dickson, Adele Woodhouse, Catherine A. Blizzard
Publikováno v:
Progress in Neurobiology. 226:102449
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0f65913abcab975a999a9f9fd877fe7
https://doi.org/10.1016/j.pneurobio.2023.102449
https://doi.org/10.1016/j.pneurobio.2023.102449