Urine-derived podocytes from steroid resistant nephrotic syndrome patients as a model for renal-progenitor derived extracellular vesicles effect and drug screening

Autor: Adele Tanzi, Lola Buono, Cristina Grange, Corinne Iampietro, Alessia Brossa, Fanny Oliveira Arcolino, Maddalena Arigoni, Raffaele Calogero, Laura Perin, Silvia Deaglio, Elena Levtchenko, Licia Peruzzi, Benedetta Bussolati

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)

Abstract Background Personalized disease models are crucial for evaluating how diseased cells respond to treatments, especially in case of innovative biological therapeutics. Extracellular vesicles (EVs), nanosized vesicles released by cells for inte

Externí odkaz: https://doaj.org/article/1d0980a33a23454f942994924d92a61f

Generation of Spike-Extracellular Vesicles (S-EVs) as a Tool to Mimic SARS-CoV-2 Interaction with Host Cells

Autor: Roberta Verta, Cristina Grange, Renata Skovronova, Adele Tanzi, Licia Peruzzi, Maria Chiara Deregibus, Giovanni Camussi, Benedetta Bussolati

Publikováno v: Cells, Vol 11, Iss 1, p 146 (2022)

Extracellular vesicles (EVs) and viruses share common features: size, structure, biogenesis and uptake. In order to generate EVs expressing the SARS-CoV-2 spike protein on their surface (S-EVs), we collected EVs from SARS-CoV-2 spike expressing human

Externí odkaz: https://doaj.org/article/0d37fa92fc714206af738d6c94d2630a

Plasma Pattern of Extracellular Vesicles Isolated from Hepatitis C Virus Patients and Their Effects on Human Vascular Endothelial Cells

Autor: Pirisi, Elena Grossini, Carlo Smirne, Sakthipriyan Venkatesan, Stelvio Tonello, Davide D’Onghia, Rosalba Minisini, Vincenzo Cantaluppi, Pier Paolo Sainaghi, Cristoforo Comi, Adele Tanzi, Benedetta Bussolati, Mario

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10197

Hepatitis C virus (HCV) patients are at increased risk of cardiovascular disease (CVD). In this study, we aimed to evaluate the role of extracellular vesicles (EVs) as pathogenic factors for the onset of HCV-related endothelial dysfunction. Sixty-fiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::47db513f1a72321825b36e7e0c25c680

Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect Human Corneal Endothelial Cells from Endoplasmic Reticulum Stress-Mediated Apoptosis

Autor: Cristina Grange, Raffaele Nuzzi, Benedetta Bussolati, Marta Tapparo, Marco De Iuliis, Simona Scalabrin, Adele Tanzi, Lola Buono

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 4930, p 4930 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 9; Pages: 4930

Corneal endothelial dystrophy is a relevant cause of vision loss and corneal transplantation worldwide. In the present study, we analyzed the effect of mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) in an in vitro model of corne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872fbcc0aed1031d3eb411f880645a27
https://www.mdpi.com/1422-0067/22/9/4930