Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Adele P Williams"'
Autor:
Laura V Bownes, Adele P Williams, Raoud Marayati, Laura L Stafman, Hooper Markert, Colin H Quinn, Nikita Wadhwani, Jamie M Aye, Jerry E Stewart, Karina J Yoon, Elizabeth Mroczek-Musulman, Elizabeth A Beierle
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0246244 (2021)
Investigation of the mechanisms responsible for aggressive neuroblastoma and its poor prognosis is critical to identify novel therapeutic targets and improve survival. Enhancer of Zeste Homolog 2 (EZH2) is known to play a key role in supporting the m
Externí odkaz:
https://doaj.org/article/00f6cc5570544d52be7e472249944929
Autor:
Laura V Bownes, Adele P Williams, Raoud Marayati, Colin H Quinn, Sara C Hutchins, Jerry E Stewart, Trung Vu, Juliet L Easlick, Elizabeth Mroczek-Musulman, David K Crossman, Joshua C Anderson, Christopher D Willey, Pran K Datta, Elizabeth A Beierle
Publikováno v:
Cancers, Vol 13, Iss 13, p 3201 (2021)
Background: Serine-threonine kinase receptor-associated protein (STRAP) plays an important role in neural development but also in tumor growth. Neuroblastoma, a tumor of neural crest origin, is the most common extracranial solid malignancy of childho
Externí odkaz:
https://doaj.org/article/9ae56fc48d8a4754b62b80bb08658eb8
Autor:
Laura L Stafman, Adele P Williams, Raoud Marayati, Jamie M Aye, Jerry E Stewart, Elizabeth Mroczek-Musulman, Elizabeth A Beierle
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214469 (2019)
Despite an increase in incidence, treatments for hepatoblastoma remain virtually unchanged for the past 20 years, emphasizing the need for novel therapeutics. FTY720 (fingolimod) is an immunomodulator approved for use in multiple sclerosis in childre
Externí odkaz:
https://doaj.org/article/ca19d782775f4addb86b63daed0b25c9
Autor:
Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Market, Michael E. Erwin, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 47, Iss , Pp 102045- (2024)
Background: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on data derived from adults. Trametinib is a kinase inhibitor that targets MEK1/2 and has been
Externí odkaz:
https://doaj.org/article/0515712cdd0f4633a52a9cf06e81c2dc
Publikováno v:
Journal of Pediatric Surgery Case Reports, Vol 84, Iss , Pp 102359- (2022)
Xanthogranulmatous pyelonephritis is a rare, chronic inflammatory pathology of the kidney. It most commonly arises in middle-aged females, but there are case reports and series described in the pediatric population. Here, we discuss the case of a 14
Externí odkaz:
https://doaj.org/article/40cbbdcfd55940fdb50355ed1beaca04
Autor:
Laura L. Stafman, Adele P. Williams, Evan F. Garner, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Kimberly Whelan, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 12, Iss 2, Pp 200-208 (2019)
Hepatoblastoma is the most common primary liver tumor in children, but treatment has not changed significantly in the past 20 years. We have previously demonstrated that Proviral Integration site for Moloney murine leukemia (PIM) kinases promote tumo
Externí odkaz:
https://doaj.org/article/50eba423670a4f4380c1edd4eb9fdaa0
Autor:
Adele P. Williams, Evan F. Garner, Alicia M. Waters, Laura L. Stafman, Jamie M. Aye, Hooper Markert, Jerry E. Stewart, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 12, Iss 1, Pp 84-95 (2019)
High-risk neuroblastoma continues to carry a poor prognosis. Nearly 50% of these tumors relapse following extensive treatment regimens. Protein phosphatase 2A (PP2A), a tumor suppressor, has been shown to be downregulated in many human cancers via mu
Externí odkaz:
https://doaj.org/article/e301bf95fdb34b2097d8ae0defd2aedc
Autor:
Raoud Marayati, Janet R. Julson, Laura V. Bownes, Colin H. Quinn, Sara C. Hutchins, Adele P. Williams, Hooper R. Markert, Andee M. Beierle, Jerry E. Stewart, Anita B. Hjelmeland, Elizabeth Mroczek-Musulman, Elizabeth A. Beierle
Publikováno v:
J Pediatr Surg
BACKGROUND/PURPOSE: Metastatic hepatoblastoma continues to pose a significant treatment challenge, primarily because the precise mechanisms involved in metastasis are not fully understood, making cell lines and preclinical models that depict the prog
Autor:
Elizabeth A. Beierle, Colin H. Quinn, Raoud Marayati, Adele P. Williams, Elizabeth Mroczek-Musulman, Laura V. Bownes, Venkatram R. Atigadda, Jerry E. Stewart
Publikováno v:
J Pediatr Surg
Introduction Retinoic acid (RA) is a differentiating agent utilized as maintenance therapy for high-risk neuroblastoma (NB), but associated toxicities limit its use. We have previously shown that a non-toxic, novel rexinoid, 9-cis-UAB30 (UAB30), decr
Autor:
Andee M. Beierle, Colin H. Quinn, Elizabeth Mroczek-Musulman, Jamie M. Aye, David K. Crossman, Adele P. Williams, Hooper R. Markert, Jerry E. Stewart, Raoud Marayati, Karina J. Yoon, Laura V. Bownes, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 14, Iss 7, Pp 101099-(2021)
Translational Oncology
Translational Oncology
Highlights • Rare, high grade neuroendocrine-like pediatric tumor has TYRO3 and ALK mutations. • Crizotinib downregulates STAT3 and ERK1/2 signaling in tumor. • In vivo analysis demonstrated crizotinib resistance. • Crizotinib resistant cells