Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Adele L Marston"'
Autor:
Kitty F Verzijlbergen, Olga O Nerusheva, David Kelly, Alastair Kerr, Dean Clift, Flavia de Lima Alves, Juri Rappsilber, Adele L Marston
Publikováno v:
eLife, Vol 3 (2014)
To protect against aneuploidy, chromosomes must attach to microtubules from opposite poles (‘biorientation’) prior to their segregation during mitosis. Biorientation relies on the correction of erroneous attachments by the aurora B kinase, which
Externí odkaz:
https://doaj.org/article/598ffcbbe7824df7bfdae8cdcff55377
Autor:
Dariusz Abramczyk, Maria del Carmen Sanchez Olmos, Adan Andres Ramirez Rojas, Daniel Schindler, Daniel Robertson, Stephen McColm, Adele L. Marston, Paul N. Barlow
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-19 (2023)
Abstract Background Komagataella phaffii (Pichia pastoris) is a methylotrophic commercially important non-conventional species of yeast that grows in a fermentor to exceptionally high densities on simple media and secretes recombinant proteins effici
Externí odkaz:
https://doaj.org/article/d96f7342d724424bbcf9697fae49fd08
Autor:
Josefin Fernius, Adele L Marston
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000629 (2009)
The cohesin complex holds sister chromatids together from the time of their duplication in S phase until their separation during mitosis. Although cohesin is found along the length of chromosomes, it is most abundant at the centromere and surrounding
Externí odkaz:
https://doaj.org/article/692d4e2ee46b4f6da75ce37901987417
Autor:
Andrew D. McAinsh, Adele L. Marston
Publikováno v:
Mcainsh, A D & Marston, A L 2022, ' The four causes : The functional architecture of centromeres and kinetochores ', Annual review of genetics, vol. 56, no. 1, pp. 279-314 . https://doi.org/10.1146/annurev-genet-072820-034559
Kinetochores are molecular machines that power chromosome segregation during the mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have knowledge of a thing only when we have grasped its cause. In our case, to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e8f4f00b6a230fa6af5493fb78b4a2
https://doi.org/10.1146/annurev-genet-072820-034559
https://doi.org/10.1146/annurev-genet-072820-034559
Autor:
Lucia F. Massari, Adele L. Marston
Publikováno v:
Massari, L F & Marston, A L 2023, ' Chromosome organization by fine-tuning an ATPase ', Genes & Development, vol. 37, no. 7-8, pp. 259-260 . https://doi.org/10.1101/gad.350627.123
Cohesin is an ATPase that drives chromosome organization through the generation of intramolecular loops and sister chromatid cohesion. Cohesin's ATPase is stimulated by Scc2 binding but attenuated by acetylation of its Smc3 subunit. In this issue ofG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f268ccc3282180035cd3f2e8b4f0146f
https://hdl.handle.net/20.500.11820/fc9cd3ab-b26f-4d61-bd40-b088ddcac6a7
https://hdl.handle.net/20.500.11820/fc9cd3ab-b26f-4d61-bd40-b088ddcac6a7
Autor:
Bettina P Mihalas, Gerard H Pieper, Cerys E Currie, David A Kelly, Geraldine M Hartshorne, Andrew D McAinsh, Richard A Anderson, Adele L Marston
Aneuploid human eggs (oocytes) are a major cause of infertility, miscarriage and chromosomal disorders. Such aneuploidies increase greatly as women age, originating from defective linkages between sister-chromatids (cohesion) in meiosis. We found evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8aba372407f70b532f47644e9d946d2
https://doi.org/10.1101/2023.01.13.523952
https://doi.org/10.1101/2023.01.13.523952
Autor:
Cerys E. Currie, Emma Ford, Lucy Benham Whyte, Deborah M. Taylor, Bettina P. Mihalas, Muriel Erent, Adele L. Marston, Geraldine M. Hartshorne, Andrew D. McAinsh
Publikováno v:
Currie, C E, Ford, E, Benham Whyte, L, Taylor, D M, Mihalas, B P, Erent, M, Marston, A L, Hartshorne, G M & McAinsh, A D 2022, ' The first mitotic division of human embryos is highly error prone ', Nature Communications, vol. 13, no. 1, 6755, pp. 6755 . https://doi.org/10.1038/s41467-022-34294-6
Human beings are made of ~50 trillion cells which arise from serial mitotic divisions of a single cell - the fertilised egg. Remarkably, the early human embryo is often chromosomally abnormal, and many are mosaic, with the karyotype differing from on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3418889f00e190fbc2fa90affc0f89
https://pubmed.ncbi.nlm.nih.gov/36347869
https://pubmed.ncbi.nlm.nih.gov/36347869
Autor:
Adele L. Marston
Publikováno v:
Marston, A L 2021, ' A sumoylation wave to anchor the genome ', Journal of Cell Biology, vol. 220, no. 12, e202110031 . https://doi.org/10.1083/jcb.202110031
Chromatin tethers to the nuclear envelope are lost during mitosis to facilitate chromosome segregation. How these connections are reestablished to ensure functional genome organization in interphase is unclear. Ptak et al. (2021. J. Cell Biol.https:/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36ab6ace01107ab5865e6c5d7e2c509
https://doi.org/10.1083/jcb.202110031
https://doi.org/10.1083/jcb.202110031