Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter

Autor: Max Patridge, Karin A. Oien, Reshma Shah, Nelofer Syed, Darren I. O'Brien, Louise Hiller, Clare Orange, Blanca Herrera, Paul Smith, Martino Monteverde, Milena Gasco, Francesca M. Buffa, Jelena Mann, Cristiana Lo Nigro, Meghan E. Maurer, Laura Lattanzio, Jonathan A. Cooper, Adrian L. Harris, Margaret C. Frame, Gabriela Kalna, Tim Crook, Linda J. Nicholson, Adele Hannigan, Lindsay C. Spender, David C. K. Chu, Catharine M L West, Johanna K. Thurlow, Gareth J. Inman

Publikováno v: Hannigan, A, Smith, P, Kalna, G, Lo Nigro, C, Orange, C, O'Brien, D I, Shah, R, Syed, N, Spender, L C, Herrera, B, Thurlow, J K, Lattanzio, L, Monteverde, M, Maurer, M E, Buffa, F M, Mann, J, Chu, D C K, West, C M L, Patridge, M, Oien, K A, Cooper, J A, Frame, M C, Harris, A L, Hiller, L, Nicholson, L J, Gasco, M, Crook, T & Inman, G J 2010, ' Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter ', Journal of Clinical Investigation, vol. 120, no. 8, pp. 2842-57 . https://doi.org/10.1172/JCI36125

The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine as a potent oncogenic fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4710c43c622a563e0be8cceeaa0a9c
https://doi.org/10.1172/jci36125

Latent membrane protein 1-induced EGFR signalling is negatively regulated by TGFα prior to neoplasia

Autor: Joanna B. Wilson, Penelope M. Tsimbouri, Gordon M. McPhee, Chrystalla Charalambous, Adele Hannigan

Publikováno v: Carcinogenesis. 28:1839-1848

The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is an oncoprotein expressed in several EBV-associated malignancies. We have utilised mice expressing the Cao strain of LMP1 in epithelia to explore the consequences of expression in viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a6fe67efd849396f8070e24c24494a
https://doi.org/10.1093/carcin/bgm055

Pre-screening test for clinical trials of Autologous γδ T lymphocyte therapy for advanced cancer

Autor: Adele Hannigan, Kathryn Campbell, Angela L. Scott, Karen J. Williams, Michael Leek

Publikováno v: Journal of Clinical Oncology. 34:e14527-e14527

e14527Background: A sub-set of T lymphocytes, the γδ T lymphocytes, play an important role in cancer suppression and modulation of tumour growth, however, the capacity for these cells to proliferat...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::486c43e30c7bdf4f7c84e4456d6b824d
https://doi.org/10.1200/jco.2016.34.15_suppl.e14527

Lymphocyte deficiency limits Epstein-Barr virus latent membrane protein 1 induced chronic inflammation and carcinogenic pathology in vivo

Autor: Penelope M. Tsimbouri, Sarah Jones, Adele Hannigan, Adrian Philbey, Colin Nixon, Joanna B. Wilson, Asif M. Qureshi

Publikováno v: Hannigan, A, Qureshi, A M, Nixon, C, Tsimbouri, P M, Jones, S, Philbey, A W & Wilson, J B 2011, ' Lymphocyte deficiency limits Epstein-Barr virus latent membrane protein 1 induced chronic inflammation and carcinogenic pathology in vivo ', Molecular Cancer, vol. 10, no. 1, pp. 11 . https://doi.org/10.1186/1476-4598-10-11
Molecular Cancer, Vol 10, Iss 1, p 11 (2011)
Molecular Cancer

Background The importance of the malignant cell environment to its growth and survival is becoming increasingly apparent, with dynamic cross talk between the neoplastic cell, the leukocyte infiltrate and the stroma. Most cancers are accompanied by le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34ca19ff445b11d3b91f40bb6b9aa17
https://hdl.handle.net/20.500.11820/8f399a58-7dcd-47da-bffe-968ad1fe90fd

The Optimization of Protocols for Proteome Difference Gel Electrophoresis (DiGE) Analysis of Preneoplastic Skin.

Autor: Adele Hannigan, Richard Burchmore, Joanna B. Wilson

Publikováno v: Journal of Proteome Research; Sep2007, Vol. 6 Issue 9, p3422-3432, 11p