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Topoisomerases catalyse changes in the topological state of DNA and are required for many aspects of DNA metabolism. While the functions of topoisomerases I and II in eukaryotes are well established, the role of topoisomerase III remains poorly defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6648641ac750996e1336a13b784b823e
https://doi.org/10.1093/nar/27.20.4050
https://doi.org/10.1093/nar/27.20.4050
Publikováno v:
Journal of Cell Science. 117:4769-4778
In Schizosaccharomyces pombe, topoisomerase III is encoded by a single gene, top3+, which is essential for cell viability and proper chromosome segregation. Deletion of rqh1+, which encodes the sole RecQ family helicase in S. pombe, suppresses the le
Publikováno v:
DNA repair. 1(6)
The Saccharomyces cerevisiae TOP3 gene encodes the type IA topoisomerase (Top3p) that is highly conserved in evolution. Deletion of TOP3 leads to a reduction in cell viability, hyper-recombination between repetitive DNA sequences, and abnormalities i
Publikováno v:
Nucleic acids research. 29(14)
In the budding yeast Saccharomyces cerevisiae the Srs2/RadH DNA helicase promotes survival after ultraviolet (UV) irradiation, and has been implicated in DNA repair, recombination and checkpoint signalling following DNA damage. A second helicase, Sgs
Extracellular ATP and ADP, released from platelets and other sites stimulate the endothelial production of prostacyclin (PGI2) by acting on G-protein-coupled P2Y1 and P2Y2 purinoceptors, contributing to the maintenance of a non-thrombogenic surface.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae0d0079e3ae8b0462191c7dc79c02a
https://europepmc.org/articles/PMC1217921/
https://europepmc.org/articles/PMC1217921/