Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Adele Gibson"'
Autor:
Shaun M. Flint, Adele Gibson, Geoff Lucas, Raghava Nandigam, Louise Taylor, Drew Provan, Adrian C. Newland, Caroline O. Savage, Robert B. Henderson
Publikováno v:
Haematologica, Vol 101, Iss 6 (2016)
Primary immune thrombocytopenia is an autoimmune disorder in which platelet destruction is a consequence of both B- and T-cell dysregulation. Flow cytometry was used to further characterize the B- and T-cell compartments in a cross-sectional cohort o
Externí odkaz:
https://doaj.org/article/d1183f911ffd472592f4f5494a930e6c
Autor:
Rebecca C. Furze, Judit Molnar, Nigel J. Parr, Faiz Ahmad, Yvette Henry, David Howe, Rajendra Singh, Martin Toal, Anna K. Bassil, Sharon G. Bernard, Robert P. Davis, Adele Gibson, N. Claire Maller, Catriona Sharp, David F. Tough, Rab K. Prinjha, Huw D. Lewis
Publikováno v:
British Journal of Clinical Pharmacology. 88:5238-5256
To improve the tolerability and therapeutic application of histone deacetylase inhibitors (HDACi), by application of an esterase-sensitive motif (ESM), to target pharmacological activity directly to mononuclear myeloid cells expressing the processing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b986a405b103538adcd6ab638dd0581c
https://doi.org/10.1111/bcp.15428
https://doi.org/10.1111/bcp.15428
Autor:
Rebecca Furze, Judit Molnar, Nigel Parr, Faiz Ahmad, Yvette Henry, David Howe, Rajendra Singh, Martin Toal, Anna Bassil, Sharon Bernard, Robert Davis, Adele Gibson, Claire Maller, Catriona Sharp, David Tough, Rab Prinjha, Huw Lewis
AIM: To improve the tolerability and therapeutic application of histone deacetylase inhibitors (HDACi), by application of an esterase-sensitive motif (ESM), to target pharmacological activity directly to mononuclear myeloid cells expressing the proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66724da03939ab05a2278fedf0bf4f6
https://doi.org/10.22541/au.164254165.50219816/v1
https://doi.org/10.22541/au.164254165.50219816/v1
Autor:
Shaun M. Flint, Rachel B Jones, Christopher J.E. Watson, Caroline O. S. Savage, Joseph A Chadwick, Nicholas Torpey, Don N Shanahan, Luke Devey, Ann-Marie O'Sullivan, Anna Richards, Robert B Henderson, Gemma D Banham, Paul A. Lyons, Kenneth G. C. Smith, Menna R. Clatworthy, Lars P. Erwig, Katie E Foster, Adele Gibson
Publikováno v:
The Lancet. 391:2619-2630
Summary Background B cells produce alloantibodies and activate alloreactive T cells, negatively affecting kidney transplant survival. By contrast, regulatory B cells are associated with transplant tolerance. Immunotherapies are needed that inhibit B-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015b18ea7152f91c02b34d06b770e3ec
https://doi.org/10.1016/s0140-6736(18)30984-x
https://doi.org/10.1016/s0140-6736(18)30984-x
Autor:
Barbara M.F. Pearse, Philip R. Evans, Marijn G. J. Ford, Matthew K. Higgins, Yvonne Vallis, Harvey T. McMahon, Adele Gibson, Colin R. Hopkins, David J. Owen
Adaptor protein 180 (AP180) and its homolog, clathrin assembly lymphoid myeloid leukemia protein (CALM), are closely related proteins that play important roles in clathrin-mediated endocytosis. Here, we present the structure of the NH 2 -terminal dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82539d03f24b309b1526748a87f781d1
https://ora.ox.ac.uk/objects/uuid:3d1ffdab-bf4a-4a18-9409-8b191e4d83d9
https://ora.ox.ac.uk/objects/uuid:3d1ffdab-bf4a-4a18-9409-8b191e4d83d9
Autor:
Drew Provan, Shaun M. Flint, Robert B Henderson, Adele Gibson, Geoff Lucas, Raghava Nandigam, Caroline O. S. Savage, Adrian C. Newland, Louise Taylor
Primary immune thrombocytopenia is an autoimmune disorder in which platelet destruction is a consequence of both B- and T-cell dysregulation. Flow cytometry was used to further characterize the B- and T-cell compartments in a cross-sectional cohort o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b62c4493c4f4ddd6aac82ea23ebd23
https://europepmc.org/articles/PMC5013956/
https://europepmc.org/articles/PMC5013956/
Autor:
Derek J. Trezise, Jean-Philippe Walhin, Noel W. Davies, Leanne Partington, Martine Hamann, Adele Gibson, Martin J. Main, Karen Affleck, Amanda Jowett
Publikováno v:
The Journal of Physiology. 587:2255-2274
Proteins of the CLCA gene family including the human ClCa1 (hClCa1) have been suggested to constitute a new family of chloride channels mediating Ca2+-dependent Cl− currents. The present study examines the relationship between the hClCa1 protein an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9895c2b1ffab15761fb23e21167c57
https://doi.org/10.1113/jphysiol.2009.170159
https://doi.org/10.1113/jphysiol.2009.170159
Autor:
Adele Gibson, Karen Affleck, Alan Peter Lewis, Nicola Thompson, Alan J. Aitken, Eric Charles Meldrum
Publikováno v:
Journal of Biological Chemistry. 280:27205-27212
Proteins of the CLCA gene family have been proposed to mediate calcium-activated chloride currents. In this study, we used detailed bioinformatics analysis and found that no transmembrane domains are predicted in hCLCA1 or mCLCA3 (Gob-5). Further ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0728ecfcd1375922689436f3c356e69
https://doi.org/10.1074/jbc.m504654200
https://doi.org/10.1074/jbc.m504654200
Autor:
Colin R. Hopkins, Ian G. Mills, Michael H. B. Stowell, Harvey T. McMahon, Bruno Marks, Yvonne Vallis, Adele Gibson
Publikováno v:
Nature. 410:231-235
Dynamin is a large GTPase with a relative molecular mass of 96,000 (Mr 96K) that is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Although its function is apparently essential for scission of newly formed vesicl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca1e0bf4ee8ab1c750036b87747962b
https://doi.org/10.1038/35065645
https://doi.org/10.1038/35065645
Autor:
S. Maxwell, Clare E. Futter, Derrick L. Domingo, Ian S. Trowbridge, E.H. Allchin, L.J. Ruddock, Colin R. Hopkins, Greg Odorizzi, Adele Gibson
Publikováno v:
The Journal of Cell Biology
Human transferrin receptors (TR) and receptors for polymeric immunoglobulins (pIgR) expressed in polarized MDCK cells maintain steady-state, asymmetric distributions on the separate basolateral and apical surfaces even though they are trafficking con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17009afd020ac3c153d827507701791
https://doi.org/10.1083/jcb.141.3.611
https://doi.org/10.1083/jcb.141.3.611