Výsledky vyhledávání - "Adele Donahue"

Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities

Autor: Takako Sasaki, David E. Birk, Olga Igoucheva, Robert P. Mecham, Machiko Arita, Vitali Alexeev, Mon-Li Chu, Ivan Stoilov, Adele Donahue, Sheila M. Adams, Carmen M. Halabi

Publikováno v: Journal of Biological Chemistry. 290:21443-21459

Fibulin-4 is an extracellular matrix protein essential for elastic fiber formation. Frameshift and missense mutations in the fibulin-4 gene (EFEMP2/FBLN4) cause autosomal recessive cutis laxa (ARCL) 1B, characterized by loose skin, aortic aneurysm, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc67ef37ccbde32cc962663c6fab5cff
https://doi.org/10.1074/jbc.m115.640425

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Chemotaxis-driven disease-site targeting of therapeutic adult stem cells in dystrophic epidermolysis bullosa

Autor: Adele Donahue, Vitali Alexeev, Jouni Uitto, Olga Igoucheva

Publikováno v: Stem Cell Research & Therapy

Background Dystrophic epidermolysis bullosa (DEB), a rare genodermatosis, is characterized by the formation of intra-epidermal blistering and the development of chronic nonhealing skin wounds. Recently, attempts have been made to develop cell-based t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf8df1044c9f56e583c424b715b548d
https://doi.org/10.1186/s13287-016-0388-y

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416 Proteomic analysis of chemokines and cytokines in blister fluids of epidermolysis bullosa patients: Implications for prognosis and therapy

Autor: Julio C. Salas-Alanis, Francis Palisson, Olga Igoucheva, Vitali Alexeev, Jouni Uitto, Adele Donahue

Publikováno v: Journal of Investigative Dermatology. 136:S73

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57c9ad4cb51118fd7f3c619dc59e7f49
https://doi.org/10.1016/j.jid.2016.02.450

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Human adipose-derived stem cell transplantation as a potential therapy for collagen VI-related congenital muscular dystrophy

Autor: Mon-Li Chu, Paolo Bonaldo, Machiko Arita, Adele Donahue, Vitali Alexeev, Olga Igoucheva

Publikováno v: Stem Cell Research & Therapy

Congenital muscular dystrophies (CMD) are a clinically and genetically heterogeneous group of neuromuscular disorders characterized by muscle weakness within the first two years of life. Collagen VI-related muscle disorders have recently emerged as o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6023e9b297186c55bc3cee02931569cd
http://europepmc.org/articles/PMC4054951

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Analysis of chemotactic molecules in bone marrow-derived mesenchymal stem cells and the skin: Ccl27-Ccr10 axis as a basis for targeting to cutaneous tissues

Autor: Jouni Uitto, Vitali Alexeev, Adele Donahue, Olga Igoucheva

Publikováno v: Cytotherapy. 15:171-184.e1

Background aims Adult stem cells produce a plethora of extracellular matrix molecules and have a high potential as cell-based therapeutics for connective tissue disorders of the skin. However, the primary challenge of the stem cell-based approach is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ba273b127cacdbaf25354576fbe389
https://doi.org/10.1016/j.jcyt.2012.11.006

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Akademický článek

Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities.

Autor: Olga Igoucheva¹, Alexeev, Vitali¹, Halabi, Carmen M.², Adams, Sheila M.³, Stoilov, Ivan², Takako Sasaki⁴, Machiko Arita¹, Adele Donahue¹, Mecham, Robert P.², Birk, David E.³, Mon-Li Chu¹ monli.chu@jefferson.edu

Publikováno v: Journal of Biological Chemistry. 8/28/2015, Vol. 290 Issue 35, p21443-21459. 17p.

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