A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.

Autor: Samantha R Oakes, David Gallego-Ortega, Prudence M Stanford, Simon Junankar, Wendy Wing Yee Au, Zoya Kikhtyak, Anita von Korff, Claudio M Sergio, Andrew M K Law, Lesley E Castillo, Stephanie L Allerdice, Adelaide I J Young, Catherine Piggin, Belinda Whittle, Edward Bertram, Matthew J Naylor, Daniel L Roden, Jesse Donovan, Alexei Korennykh, Christopher C Goodnow, Moira K O'Bryan, Christopher J Ormandy

Publikováno v: PLoS Genetics, Vol 13, Iss 11, p e1007072 (2017)

We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in hea

Externí odkaz: https://doaj.org/article/76d21e2f20924475a4c47cb697a95a92

Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish

Autor: Jana Travnickova, Sarah Muise, Sonia Wojciechowska, Alessandro Brombin, Zhiqiang Zeng, Adelaide I. J. Young, Cameron Wyatt, E. Elizabeth Patton

Publikováno v: Disease Models and Mechanisms
Travnickova, J, Muise, S, Wojciechowska, S, Brombin, A, Zeng, Z, Young, A I J, Wyatt, C & Patton, E E 2022, ' Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish ', Disease Models and Mechanisms . https://doi.org/10.1242/dmm.049566

Melanoma heterogeneity and plasticity underlie therapy resistance. Some tumour cells possess innate resistance, while others reprogramme during drug exposure and survive to form persister cells, a source of potential cancer cells for recurrent diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087a2b1e51b170110b1365f19cd2f383
https://doi.org/10.1242/dmm.049566

Andy’s Algorithms: new automated digital image analysis pipelines for FIJI

Autor: Catherine E Caldon, Andrew M. K. Law, Sandra A O'Toole, Andrew Burgess, Lesley Castillo, Julia X. M. Yin, Samuel Rogers, David Gallego-Ortega, Ewan K.A. Millar, Christopher J. Ormandy, Catherine L. Piggin, Samantha R. Oakes, Adelaide I. J. Young

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports

Quantification of cellular antigens and their interactions via antibody-based detection methods are widely used in scientific research. Accurate high-throughput quantitation of these assays using general image analysis software can be time consuming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a353ebe7fef2cc1cfd60a8aec380fd9a
https://doi.org/10.1038/s41598-017-15885-6

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

Autor: Sabrina Chong, Paul Timpson, Lesley Castillo, David Herrmann, Erinna F. Lee, Ewan K.A. Millar, Amr H. Allam, Adelaide I. J. Young, Morghan C. Lucas, Hayley Daniella Cullen, Andrew M. K. Law, Tilman Brummer, Sebastian Herzog, Martin Koehler, W.D. Fairlie, David Gallego-Ortega, Christopher J. Ormandy, D. Neil Watkins, Sandra A O'Toole, Samantha R. Oakes

Publikováno v: Breast Cancer Research : BCR

Background Metastatic disease is largely resistant to therapy and accounts for almost all cancer deaths. Myeloid cell leukemia-1 (MCL-1) is an important regulator of cell survival and chemo-resistance in a wide range of malignancies, and thus its inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c629349743432082026c46d23aa19dd3
https://pubmed.ncbi.nlm.nih.gov/27931239