Therapeutic efficiency of the APAF‐1 antagonist LPT99 in a rat model of cisplatin‐induced hearing loss

Autor: Silvia Murillo‐Cuesta, Adelaida M Celaya, Blanca Cervantes, Jose M Bermúdez‐Muñoz, Lourdes Rodríguez‐de la Rosa, Julio Contreras, Isabel Sánchez‐Pérez, Isabel Varela‐Nieto

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 4, Pp n/a-n/a (2021)

Externí odkaz: https://doaj.org/article/fc9f5b79c9594d15a1502454f34f37e5

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

Autor: Meritxell Espino Guarch, Mariona Font-Llitjós, Silvia Murillo-Cuesta, Ekaitz Errasti- Murugarren, Adelaida M Celaya, Giorgia Girotto, Dragana Vuckovic, Massimo Mezzavilla, Clara Vilches, Susanna Bodoy, Ignasi Sahún, Laura González, Esther Prat, Antonio Zorzano, Mara Dierssen, Isabel Varela-Nieto, Paolo Gasparini, Manuel Palacín, Virginia Nunes

Publikováno v: eLife, Vol 7 (2018)

Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid

Externí odkaz: https://doaj.org/article/503c7861f97c46ce95ce9813d6079273

Transforming growth factor β1 inhibition protects from noise-induced hearing loss

Autor: Silvia eMurillo-Cuesta, Lourdes eRodríguez-de La Rosa, Julio eContreras, Adelaida M Celaya, Guadalupe eCamarero, Teresa eRivera, Isabel eVarela-Nieto

Publikováno v: Frontiers in Aging Neuroscience, Vol 7 (2015)

Excessive exposure to noise damages the principal cochlear structures leading to hearing impairment. Inflammatory and immune responses are central mechanisms in cochlear defensive response to noise but, if unregulated, they contribute to inner ear da

Externí odkaz: https://doaj.org/article/3171227a68194ddb8b8df6e3d9128905

Therapeutic efficiency of the APAF‐1 antagonist LPT99 in a rat model of cisplatin‐induced hearing loss

Autor: Adelaida M. Celaya, Isabel Sánchez-Pérez, Julio Contreras, Lourdes Rodriguez-de la Rosa, Silvia Murillo-Cuesta, Jose M Bermúdez-Muñoz, Isabel Varela-Nieto, Blanca Cervantes

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 4, Pp n/a-n/a (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Clinical and Translational Medicine

© 2021 The Authors
Cis-diammine-dichloroplatinum[II] (cisplatin) is a potent and widely used chemotherapeutic agent with significant efficacy against several forms of cancer in adults and children. Unfortunately, cisplatin has multiple adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da89b1fddd3fbbc355e65d3feba94754
https://doaj.org/article/fc9f5b79c9594d15a1502454f34f37e5

G6PD overexpression protects from oxidative stress and age‐related hearing loss

Autor: Jing Wang, Isabel Varela-Nieto, Manuel Serrano, Jose M Bermúdez-Muñoz, Adelaida M. Celaya, Sara Hijazo-Pechero

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Aging Cell
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid

Aging of the auditory system is associated with the incremental production of reactive oxygen species (ROS) and the accumulation of oxidative damage in macromolecules, which contributes to cellular malfunction, compromises cell viability, and, ultima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d0542188de21edd3051ba5b48687de
http://hdl.handle.net/10261/226341