Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Adela G, de la Campa"'
Autor:
Miriam García-López, Pablo Hernández, Diego Megias, María-José Ferrándiz, Adela G. de la Campa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15800 (2023)
Topoisomerase I (TopoI) in Streptococcus pneumoniae, encoded by topA, is a suitable target for drug development. Seconeolitsine (SCN) is a new antibiotic that specifically blocks this enzyme. We obtained the topARA mutant, which encodes an enzyme les
Externí odkaz:
https://doaj.org/article/5b6e8a0cd3de490aa1c17ab9a21c3ac8
Publikováno v:
Frontiers in Microbiology, Vol 13 (2023)
Two enzymes are responsible for maintaining supercoiling in the human pathogen Streptococcus pneumoniae, gyrase (GyrA2GyrB2) and topoisomerase I. To attain diverse levels of topoisomerase I (TopoI, encoded by topA), two isogenic strains derived from
Externí odkaz:
https://doaj.org/article/cfc058b24dac4902a173c4ebf2b59885
Autor:
Antonio A. de Vasconcelos Junior, Jose M. Tirado-Vélez, Antonio J. Martín-Galiano, Diego Megias, María-José Ferrándiz, Pablo Hernández, Mónica Amblar, Adela G. de la Campa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5973 (2023)
The DNA topoisomerases gyrase and topoisomerase I as well as the nucleoid-associated protein HU maintain supercoiling levels in Streptococcus pneumoniae, a main human pathogen. Here, we characterized, for the first time, a topoisomerase I regulator p
Externí odkaz:
https://doaj.org/article/ad4e4f0121994a26b6969b572032d929
Publikováno v:
Antibiotics, Vol 11, Iss 12, p 1837 (2022)
PatAB is an ABC bacterial transporter that facilitates the export of antibiotics and dyes. The overexpression of patAB genes conferring efflux-mediated fluoroquinolone resistance has been observed in several laboratory strains and clinical isolates o
Externí odkaz:
https://doaj.org/article/2d4f32afd1ea417288483c8c6362982e
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009542 (2021)
Streptococcus pneumoniae is a major cause of disease and death that develops resistance to multiple antibiotics. DNA topoisomerase I (TopoI) is a novel pneumococcal drug target. TopoI is the sole type-I pneumococcal topoisomerase that regulates super
Externí odkaz:
https://doaj.org/article/c1a25e74551142e4b98eab21e23fbe00
Autor:
Rodrigo Sánchez-Tarjuelo, Isabel Cortegano, Juliana Manosalva, Mercedes Rodríguez, Carolina Ruíz, Mario Alía, María Carmen Prado, Eva M. Cano, María José Ferrándiz, Adela G. de la Campa, María Luisa Gaspar, Belén de Andrés
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Streptococcus pneumoniae is the main cause of bacterial pneumonia, a condition that currently produces significant global morbidity and mortality. The initial immune response to this bacterium occurs when the innate system recognizes common motifs ex
Externí odkaz:
https://doaj.org/article/a1e658d49c294935a0963c7bbcb0207f
Autor:
Myriam V Valenzuela, Mirian Domenech, Patricia Mateos-Martínez, Fernando González-Camacho, Adela G de la Campa, Maria Teresa García
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241780 (2020)
The DNA topoisomerase complement of Streptococcus pneumoniae is constituted by two type II enzymes (topoisomerase IV and gyrase), and a single type I enzyme (topoisomerase I). These enzymes maintain the DNA topology, which is essential for replicatio
Externí odkaz:
https://doaj.org/article/bfeebf25864e4a428c1b52f1ea58a734
Autor:
Jose Manuel Tirado-Vélez, David Carreño, David Sevillano, Luis Alou, José Yuste, Adela G. de la Campa
Publikováno v:
Antibiotics, Vol 10, Iss 5, p 573 (2021)
Antibiotic resistance in Streptococcus pneumoniae has increased worldwide, making fluoroquinolones an alternative therapeutic option. Fluoroquinolones inhibit the type II DNA topoisomerases (topoisomerase IV and gyrase). In this study we have evaluat
Externí odkaz:
https://doaj.org/article/5b7a65b8d6b0468da794a1ec4d399a0f
Autor:
Antonio J. Martín-Galiano, María S. Escolano-Martínez, Bruno Corsini, Adela G. de la Campa, José Yuste
Publikováno v:
Vaccines, Vol 9, Iss 3, p 187 (2021)
Knowledge-based vaccinology can reveal uncharacterized antigen candidates for a new generation of protein-based anti-pneumococcal vaccines. DiiA, encoded by the sp_1992 locus, is a surface protein containing either one or two repeats of a 37mer N-ter
Externí odkaz:
https://doaj.org/article/fc1bd746dd9b4593b7e89f3ba1b0b31d
Autor:
María T. García, David Carreño, José M. Tirado-Vélez, María J. Ferrándiz, Liliana Rodrigues, Begoña Gracia, Mónica Amblar, José A. Ainsa, Adela G. de la Campa
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
The spread of multidrug-resistant isolates of Mycobacterium tuberculosis requires the discovery of new drugs directed to new targets. In this study, we investigated the activity of two boldine-derived alkaloids, seconeolitsine (SCN) and N-methyl-seco
Externí odkaz:
https://doaj.org/article/5476a01f6c15470fa276df089ffbc49d