Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Adel Tarcsafalvi"'
Autor:
Daniel J. Neitzke, Daniel Gioeli, Adel Tarcsafalvi, Mark J. Axelrod, Michael J. Weber, Vicki L. Gordon, Mark R. Conaway
Publikováno v:
Oncotarget
// Mark Axelrod 1 , Vicki L. Gordon 1 , Mark Conaway 2 , Adel Tarcsafalvi 1,3 , Daniel J. Neitzke 1,4 , Daniel Gioeli 1 , and Michael J. Weber 1 1 Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, USA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033ac8fb9696a77ce6c64b36e89a7eba
http://europepmc.org/articles/PMC3720609
http://europepmc.org/articles/PMC3720609
Publikováno v:
Cell Death Discovery
Cisplatin is a widely used chemotherapeutic agent, yet its efficacy is limited by nephrotoxicity. The severity of nephrotoxicity is associated with the extent of kidney cell death. Previously, we found that cisplatin-induced kidney cell death was dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a634cf9127eeab5bb4bf3c4e5095921
https://doi.org/10.1038/cddiscovery.2016.1
https://doi.org/10.1038/cddiscovery.2016.1
Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak
Publikováno v:
Cell Death Discovery
Apoptosis is a regulated form of cell death that proceeds by defined biochemical pathways. Most apoptosis is controlled by interactions between pro-survival and pro-apoptotic Bcl-2 family proteins in which death is often the consequence of permeabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bce416923d84a149d0ca80fbd83a79c
https://doi.org/10.1038/cddiscovery.2015.66
https://doi.org/10.1038/cddiscovery.2015.66
Publikováno v:
American Journal of Physiology-Renal Physiology. 300:F1171-F1179
Cisplatin cytotoxicity is dependent on cyclin-dependent kinase 2 (Cdk2) activity in vivo and in vitro. We found that an 18-kDa protein identified by mass spectrometry as p21WAF1/Cip1was phosphorylated by Cdk2 starting 12 h after cisplatin exposure. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab53682c816b856f04c165b9282d8a5
https://doi.org/10.1152/ajprenal.00507.2010
https://doi.org/10.1152/ajprenal.00507.2010
Publikováno v:
American Journal of Physiology-Renal Physiology. 299:F112-F120
Cisplatin cytotoxicity is dependent on cyclin-dependent kinase 2 (Cdk2) activity in vivo and in vitro. A Cdk2 mutant (Cdk2-F80G) was designed in which the ATP-binding pocket was altered. When expressed in mouse kidney cells, this protein was kinase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781843b05291d43f3af66d4f652808f5
https://doi.org/10.1152/ajprenal.00151.2010
https://doi.org/10.1152/ajprenal.00151.2010
Publikováno v:
Journal of Cellular Biochemistry. 105:875-884
Ovarian cancer metastasis involves the sloughing of epithelial cells from the ovary into the peritoneal cavity, where the cells can survive and proliferate in peritoneal ascites under anchorage-independent conditions. For normal epithelial cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad67b03b2fd00e529485d19d63cfdf0
https://doi.org/10.1002/jcb.21889
https://doi.org/10.1002/jcb.21889
Autor:
Tomáš Vomastek, Hans-Joerg Schaeffer, Mark E. Smolkin, Adel Tarcsafalvi, Michael Weber, Eric A. Bissonette
Publikováno v:
Proceedings of the National Academy of Sciences. 101:6981-6986
Signal transduction occurs by the reversible assembly of oligomeric protein complexes that include both enzymatic proteins and proteins without known enzymatic activity. These nonenzymatic components can serve as scaffolds or anchors and regulate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eed2de0079520884b1cdf0831587e0a
https://doi.org/10.1073/pnas.0305894101
https://doi.org/10.1073/pnas.0305894101
Publikováno v:
The Journal of Immunology. 170:1383-1391
IL-10 has proved to be a key cytokine in regulating inflammatory responses by controlling the production and function of various other cytokines. The suppressor of cytokine signaling (SOCS) gene products are a family of cytoplasmic molecules that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b1254f39fa15f9a94a8ba38b65f4b2
https://doi.org/10.4049/jimmunol.170.3.1383
https://doi.org/10.4049/jimmunol.170.3.1383
Autor:
J. Thomas Parsons, Mark S. Marshall, Scott T. Eblen, Michael J. Weber, Adel Tarcsafalvi, H. Bruce Diaz, Jill K. Slack-Davis, Andrew D. Catling, Maja Zecevic, Scott A. Boerner
Publikováno v:
The Journal of Cell Biology
Activation of the Ras–MAPK signal transduction pathway is necessary for biological responses both to growth factors and ECM. Here, we provide evidence that phosphorylation of S298 of MAPK kinase 1 (MEK1) by p21-activated kinase (PAK) is a site of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078857cc308cecea59ac406837224641
http://europepmc.org/articles/PMC2172784
http://europepmc.org/articles/PMC2172784
Autor:
Adel Tarcsafalvi, Didier Portilla, Nang San Hti Lar Seng, Shenyang Li, Rawad Hodeify, Peter M. Price, Judit Megyesi
Publikováno v:
American journal of physiology. Renal physiology. 308(2)
Tissue fibrosis is a major cause of death in developed countries. It commonly occurs after either acute or chronic injury and affects diverse organs, including the heart, liver, lung, and kidney. Using the renal ablation model of chronic kidney disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bf17acc7d8026e5df82c51f0541460
https://pubmed.ncbi.nlm.nih.gov/25428126
https://pubmed.ncbi.nlm.nih.gov/25428126