Výsledky vyhledávání - "Adel S. Abdelraheem"

Design, synthesis, anticancer evaluation, in silico docking and ADMET analysis of novel indole-based thalidomide analogs as promising immunomodulatory agents

Autor: Mohamed Ayman El-Zahabi, Hazem Elkady, Helmy Sakr, Adel S. Abdelraheem, Sally I. Eissa, Khaled. El-Adl

In the present work, novel 16 indole-based thalidomide analogs were designed and synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized compounds were evaluated for their cytotoxic activities against HepG-2, HCT-116, P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db46a196ec3fac0d375af3a1051e6213

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Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents

Autor: Hazem Elkady, Mohamed El-Zahabi, Helmy Sakr, Khaled El-Adl, Sally I. Eissa, Mohamed F. Zayed, Ibrahim H. Eissa, Adel S. Abdelraheem

Publikováno v: Bioorganic chemistry. 104

Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of certain inflammatory mediators associated with cancer. In the present work, a new series of thalidomide analogs was designed and synthesized to obtain new effective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42292ad44a1eee0e70d964ac132b8801
https://pubmed.ncbi.nlm.nih.gov/32932121

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