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Akademický článek

Acetovanillone augmented the cardioprotective effect of carvedilol against cadmium-induced heart injury via suppression of oxidative stress and inflammation signaling pathways

Autor: Emad H. M. Hassanein, Adel G. Bakr, Ehab A. M. El-Shoura, Lamiaa Khalaf Ahmed, Fares E. M. Ali

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract Cardiac toxicity is a public health issue that can be caused by both environmental and occupational exposures. The current study aimed to investigate the effectiveness of carvedilol (CV), Acetovanillone (ACET), and their combination for amel

Externí odkaz: https://doaj.org/article/8bd8d0b332ef44f68791432b367a7f0b

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Efficacy and Safety of Pentoxifylline on Patients with Non-Alcoholic Steatohepatitis; Randomized Controlled Trial

Autor: Ahmed Abomandour, Adel G. Bakr, Ahmed Mohamed ElGhandour, Hosny Ahmed Elewa, Maha Abdel Rhman, Zeinab Al Kasaby Zalat

Background: Actually, no specific treatment has been endorsed by FDA for non-alcoholic steatohepatitis (NASH). The present research aimed to evaluate the efficacy of PTX on NASH patients for 6 months compared to NASH patients who received regular tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1455a4ce68e7484b1bd4f7bd62f016cf
https://doi.org/10.21203/rs.3.rs-2551241/v1

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Combined apocynin and carvedilol protect against cadmium-induced testicular damage via modulation of inflammatory response and redox-sensitive pathways

Autor: Adel G, Bakr, Emad H M, Hassanein, Fares E M, Ali, Ehab A M, El-Shoura

Publikováno v: Life Sciences. 311:121152

Testicular damage is considered a severe complication of cadmium (Cd) exposure which is associated with tissue oxidative stress damage, inflammation, and apoptosis. The present study investigated the antioxidant, anti-inflammatory, and anti-apoptotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f09df17393dbd49612919bacfffe275
https://doi.org/10.1016/j.lfs.2022.121152

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Perindopril mitigates LPS-induced cardiopulmonary oxidative and inflammatory damage via inhibition of renin angiotensin system, inflammation and oxidative stress

Autor: Souty M.Z. Sharkawi, Ehab A M El-Shoura, Ramadan A.M. Hemeida, Adel G. Bakr, Basim A.S. Messiha

Publikováno v: Immunopharmacology and Immunotoxicology. 41:630-643

Aim: Renin–angiotensin system (RAS) is thought to have a noticeable effect in the pathophysiological injury in multiple organs by inducing different cellular and molecular reactions. The objective ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee69dacbd30ffc7ea50a2ca92e0f7542
https://doi.org/10.1080/08923973.2019.1688346

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Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway

Autor: Ramadan A.M. Hemeida, Adel G. Bakr, Amira M. Abo-Youssef, Fares E.M. Ali, Amany A. Azouz

Publikováno v: Food and Chemical Toxicology. 120:294-304

The present study was designed to investigate the potential protective effects of diosmin (DS) and/or sildenafil against bile duct ligation (BDL). In order to achieve this goal, BDL was performed to induce liver cirrhosis, DS (100 mg/kg/day, p.o.) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1179e7ec14bb77638aa59979e6321cec
https://doi.org/10.1016/j.fct.2018.07.027

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Diosmin enhances the anti-angiogenic activity of sildenafil and pentoxifylline against hepatopulmonary syndrome via regulation of TNF-α/VEGF, IGF-1/PI3K/AKT, and FGF-1/ANG-2 signaling pathways

Autor: Adel G. Bakr, Fares E.M. Ali, Ali H. El-Bahrawy, Hesham H. Taha

Publikováno v: European journal of pharmacology. 873

Hepatopulmonary syndrome (HPS) is a severe complication of hepatic cirrhosis, which is characterized by hypoxia, intrapulmonary vasodilation, inflammation, and angiogenesis. In this study, we aimed to investigate the regulatory effects of diosmin (DS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83776e5c50f86a574b398b2975adc300
https://pubmed.ncbi.nlm.nih.gov/32050083

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Novel water-soluble lubricant for the preparation of tiemonium methylsulfate fast-dissolving tablets

Autor: Doaa H. Alshora, Mohammed A. Amin, Mohamed Ibrahim, Omar H. El-Garhy, Gamal M. Zayed, Adel G. Bakr, Fares E.M. Ali, Islam Kamal

Publikováno v: Journal of Drug Delivery Science and Technology. 60:102031

The rapid delivery and self-administration of antispasmodics are very essential for the treatment of pain associated with smooth muscle spasms. Tiemonium methylsulfate (TMS) is a well-known antispasmodic drug used in the treatment of muscle spasms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b4ddadb6a682c7cd95b62cf27ea0e6f
https://doi.org/10.1016/j.jddst.2020.102031

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Effects of carbon monoxide-releasing molecules on pulmonary vasoreactivity in isolated perfused lungs

Autor: Ievgen Strielkov, Natascha Sommer, Timm Hoeres, Matthias Hecker, Julia Albus, Mareike Gierhardt, Werner Seeger, Florian Kroschel, Oleg Pak, Norbert Weissmann, Hossein Ardeschir Ghofrani, Adel G. Bakr

Publikováno v: Journal of Applied Physiology. 120:271-281

In addition to its renowned poisonous effects, carbon monoxide (CO) is being recognized for its beneficial actions on inflammatory and vasoregulatory pathways, particularly when applied at low concentrations via CO-releasing molecules (CO-RMs). In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0409f44c258bd05d6ff3390c225049
https://doi.org/10.1152/japplphysiol.00726.2015

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