Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Adel F. Youssef"'
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Akademický článek
Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1,2,3-triazole-4-yl derivatives as topoisomerase II inhibitors
Autor: Gehan A. Abdel-Hafez, Abdel-Maaboud I. Mohamed, Adel F. Youssef, Claire Simons, Ahmed S. Aboraia
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 502-513 (2022)
Topoisomerase (IIB) inhibitors have been involved in the therapies of tumour progression and have become a major focus for the development of anticancer agents. New three-component hybridised ligands, 1,4-disubstituted-1,2,3-triazoles (8–17), were
Externí odkaz: https://doaj.org/article/f1153cf0cf27428a94e6dbd42b10f12a
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2
Development and validation of a high-performance thin-layer chromatography densitometric method for the simultaneous determination of novel 1-acridinyl-1,2,3-triazole derivatives
Autor: Gehan A. Abdel-Hafez, Ahmed S. Aboraia, Abdel-Mabood I. Mohammad, Adel F. Youssef
Publikováno v: JPC – Journal of Planar Chromatography – Modern TLC. 35:349-362
High-performance thin-layer chromatographic (HPTLC) method provides a simple, sensitive, and accurate analytical method for the simultaneous determination of certain synthesized 1-acridinyl-1,2,3-triazole derivatives without interference from startin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89f76bcc92ff77040f4990d8199e1c1f
https://doi.org/10.1007/s00764-022-00193-1
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3
Cu (I) catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC): Synthesis of 17α-[1-(substituted phenyl)-1,2,3-triazol-4-yl]-19-nor-testosterone-17β-yl acetates targeting progestational and antipro-liferative activities
Autor: Nawal A. El-Koussi, Gehad A. Abdel Jaleel, Adel F. Youssef, Z.H. Mohamed, Samia A. Shouman, Nadia M. Mahfouz
Publikováno v: European Journal of Medicinal Chemistry. 97:75-82
The progestational potency and selectivity of synthetic steroidal agonists can be enhanced by even larger chemical moieties at 17α-position of the steroid backbones. Hereby a series 5a-c and 6a-c of novel 17α-[1-(substituted phenyl)-1,2,3-triazol-4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b386f09ee865d0f9e396ee9de77c94
https://doi.org/10.1016/j.ejmech.2015.04.045
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5
Biotransformation studies of prednisone using human intestinal bacteria Part II: Anaerobic incubation and docking studies
Autor: Atef A. Abdel-Hafez, Adel F. Youssef, Farghaly A. Omar, Mohamed M. Al-Sanea
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry. 24:1211-1219
Anaerobic incubation of prednisone 1 with human intestinal bacteria (HIB) afforded nine metabolites: 5beta-androst-1-ene-3,11,17-trione 3, 3alpha-hydroxy-5alpha-androstane-11,17-dione 4, 3beta,17alpha,20-trihydroxy-5alpha-pregnan-11-one 5, 3alpha,17a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7122469d5605442eb721a667edbf7af5
https://doi.org/10.3109/14756360902781322
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7
A Novel Dipeptide-based HIV Protease Inhibitor Containing Allophenylnorstatine
Autor: Nawal A. El-Koussi, Adel F. Youssef, Hamdy M. Abdel-Rahman, Yoshiaki Kiso, Gamal S. Alkaramany
Publikováno v: Archiv der Pharmazie. 337:587-598
Dipeptide analogues incorporating allophenylnorstatine [Apns; (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid] as a transition state mimic at the scissile bond were designed and synthesized in the hope of obtaining a novel KNI series of HIV protease i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b5f1bac6b3ae346ca8180f043babd3
https://doi.org/10.1002/ardp.200400882
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DESIGN, SYNTHESIS AND ANTIDEPRESSANT ACTIVITY OF SOME N2-SUBSTITUTED NALIDIXIC ACID HYDRAZIDES AND THEIR CYCLIZED ANALOGUES
Autor: Gamal El Din A. A. Abuo-Rahma, Adel F. Youssef, Farghaly A. Omar, Hosney A. Elsherief
Publikováno v: Bulletin of Pharmaceutical Sciences. Assiut. 21:15-26
A series of N2-substituted nalidixic acid hydrazides 7-26 and some of their rigid analogues 29-31 in which the hydrazinocarbonyl moiety has been replaced by the corresponding 1,3,4-oxadiazole nucleus were synthesized as potential antidepressant agent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb1dd98f66daa6ad5970d733ef057510
https://doi.org/10.21608/bfsa.1998.67767
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SYNTHESIS AND INVESTIGATION OF CERTAIN 3(5)- SUBSTITUFED-1,2,4- TRIAZOLE-5(3)-CARBOXYLIC ACID DERIVATIVES
Autor: G. S. El-Karamany, Adel F. Youssef, Hoda Y. Hassan, Nawal A. El-Koussi, Hany M. Mohamed, Atef A. Abdel-Hafez
Publikováno v: Bulletin of Pharmaceutical Sciences. Assiut. 20:47-61
A series of 3(5)-substituted 1,2,4-triazole-5(3)-carboxylic acid amides, hydroxamic, hydrazide, iminosemicarbazide, semicarbazide and thiosemicarbazide have been synthesized. Most of the prepared compounds were tested for their growth inhibitory acti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::791d350566b79d26f37d2aa795d0bacd
https://doi.org/10.21608/bfsa.1997.68738
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10
Pharmacophoric model building for antitubercular activity of the individual Schiff bases of small combinatorial library
Autor: Hoda Y. Hassan, Wesam S. Abdel-Aal, Tarek Aboul-Fadl, Adel F. Youssef
Publikováno v: European journal of medicinal chemistry. 45(3)
Synthesis and evaluation of anti-TB activity of individual compounds of Schiff bases combinatorial library were done against Mycobacterium tuberculosis H 37 Rv at a single concentration of 6.25 μg/mL according to the protocol of TAACF. Compounds 2C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224e76d9d4e55a064ecacac15905e4a9
https://pubmed.ncbi.nlm.nih.gov/20045582
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