The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle.

Autor: Nadège Poncet, Fiona E Mitchell, Adel F M Ibrahim, Victoria A McGuire, Grant English, J Simon C Arthur, Yun-Bo Shi, Peter M Taylor

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89547 (2014)

The System L1-type amino acid transporter mediates transport of large neutral amino acids (LNAA) in many mammalian cell-types. LNAA such as leucine are required for full activation of the mTOR-S6K signalling pathway promoting protein synthesis and ce

Externí odkaz: https://doaj.org/article/faf64e31f1d8416fabeefd8b6f377ac6

The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces.

Autor: Edmond Wong, Gustav Vaaje-Kolstad, Avishek Ghosh, Ramon Hurtado-Guerrero, Peter V Konarev, Adel F M Ibrahim, Dmitri I Svergun, Vincent G H Eijsink, Nabendu S Chatterjee, Daan M F van Aalten

Publikováno v: PLoS Pathogens, Vol 8, Iss 1, p e1002373 (2012)

Vibrio cholerae is a bacterial pathogen that colonizes the chitinous exoskeleton of zooplankton as well as the human gastrointestinal tract. Colonization of these different niches involves an N-acetylglucosamine binding protein (GbpA) that has been r

Externí odkaz: https://doaj.org/article/770d539436de4006b01fbb1db03c7b29

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

Autor: W. Abdulrahman, Adel F. M. Ibrahim, Ronald T. Hay, Martin Renatus, Aimee H. Marceau, Ulrich Hassiepen, Simone Cavadini, Antoine H.F.M. Peters, Seth M. Rubin, Julius Rabl, Jacob D. Aguirre, Tewis Bouwmeester, Richard D. Bunker, Nicolas H. Thomä, H. van Attikum, Niels Mailand, M.E. Gill, Andreas D. Schenk, Emma Branigan, Claire Guérillon, A. Andres-Pons, L. Gelman, Luijsterburg

Publikováno v: Molecular Cell
Molecular Cell, 75 (3)
Molecular Cell, 75(3), 483-+. CELL PRESS
Rabl, J, Bunker, R D, Schenk, A D, Cavadini, S, Gill, M E, Abdulrahman, W, Andrés-Pons, A, Luijsterburg, M S, Ibrahim, A F M, Branigan, E, Aguirre, J D, Marceau, A H, Guérillon, C, Bouwmeester, T, Hassiepen, U, Peters, A H F M, Renatus, M, Gelman, L, Rubin, S M, Mailand, N, van Attikum, H, Hay, R T & Thomä, N H 2019, ' Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation ', Molecular Cell, vol. 75, no. 3, pp. 483-497.e9 . https://doi.org/10.1016/j.molcel.2019.06.002

Summary In mammals, ∼100 deubiquitinases act on ∼20,000 intracellular ubiquitination sites. Deubiquitinases are commonly regarded as constitutively active, with limited regulatory and targeting capacity. The BRCA1-A and BRISC complexes serve in D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7932a90a03964af070a66d7ce8ca586b
http://europepmc.org/articles/PMC6695476

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

Autor: David G. Campbell, Adel F. M. Ibrahim, Shalini Pathak, Osama Albarbarawi, Daan M. F. van Aalten, Vladimir S. Borodkin

Publikováno v: The EMBO Journal. 31:1394-1404

Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) is a key serine/threonine protein kinase that mediates signals transduced by pro-inflammatory cytokines such as transforming growth factor-β, tumour necrosis factor (TNF), interleukin-1 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60eb787f1379b1ce339ad086059b8f61
https://doi.org/10.1038/emboj.2012.8

Molecular Mechanisms of Yeast Cell Wall Glucan Remodeling

Autor: Isabelle Mouyna, Thierry Fontaine, Adel F. M. Ibrahim, Sharon M. Shepherd, Jean-Paul Latgé, Ramon Hurtado-Guerrero, Daan M. F. van Aalten, Alexander W. Schüttelkopf

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2009, 284 (13), pp.8461-8469. ⟨10.1074/jbc.M807990200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (13), pp.8461-8469. ⟨10.1074/jbc.M807990200⟩

International audience; Yeast cell wall remodeling is controlled by the equilibrium between glycoside hydrolases, glycosyltransferases, and transglycosylases. Family 72 glycoside hydrolases (GH72) are ubiquitous in fungal organisms and are known to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f121e187188c07b086024064cb01358
https://doi.org/10.1074/jbc.m807990200