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of 4
pro vyhledávání: '"Adedeji M. Aderounmu"'
Autor:
Claudia D Consalvo, Adedeji M Aderounmu, Helen M Donelick, P Joseph Aruscavage, Debra M Eckert, Peter S Shen, Brenda L Bass
Publikováno v:
eLife, Vol 13 (2024)
Invertebrates use the endoribonuclease Dicer to cleave viral dsRNA during antiviral defense, while vertebrates use RIG-I-like Receptors (RLRs), which bind viral dsRNA to trigger an interferon response. While some invertebrate Dicers act alone during
Externí odkaz:
https://doaj.org/article/a4b7fc7d9f3141feb17511bbe5b926d0
Publikováno v:
eLife, Vol 12 (2023)
Antiviral defense in ecdysozoan invertebrates requires Dicer with a helicase domain capable of ATP hydrolysis. But despite well-conserved ATPase motifs, human Dicer is incapable of ATP hydrolysis, consistent with a muted role in antiviral defense. To
Externí odkaz:
https://doaj.org/article/b8b7ef5a2534413491d9bf54bff6ef46
Publikováno v:
Cold Spring Harbor symposia on quantitative biology
The function of Dicer’s helicase domain has been enigmatic since its discovery. Why do only some Dicers require ATP, despite a high degree of sequence conservation in their helicase domains? We discuss evolutionary considerations based on differenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a2d93c6aee1f2bdc858c1a680dd14a
https://doi.org/10.1101/sqb.2019.84.039750
https://doi.org/10.1101/sqb.2019.84.039750