Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Addepalli, Pavani"'
Autor:
Shaik Mohammad Naushad, Vijay Kumar Kutala, Suryanarayana Raju Gottumukkala, Raghunadha Rao Digumarti, Yedluri Rupasree, Shree Divyya, Addepalli Pavani
Publikováno v:
Journal of Medical and Allied Sciences, Vol 1, Iss 1, Pp 7-13 (2011)
This study addresses the issues in translating the laboratory derived data obtained during discovery phase of research to a clinical setting using a breast cancer model. Laboratory-based risk assessment indi-cated that a family history of breast canc
Externí odkaz:
https://doaj.org/article/e159b41919ea4143a1d643b57a293132
Autor:
Shaik Mohammad Naushad, Addepalli Pavani, Salman A. H. Alrokayan, Tajamul Hussain, Digumarti Raghunadharao, P Dorababu, Yedluri Rupasree, Vijay Kumar Kutala
Publikováno v:
Cancer Chemotherapy and Pharmacology. 83:875-880
The rationale of the current study was to develop 6-mercaptopurine (6-MP)-mediated hematological toxicity prediction model for acute lymphoblastic leukemia (ALL) therapeutic management. A total of 96 children with ALL undergoing therapy with MCP-841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e658a516a307e56f70ce9deb558d91eb
https://doi.org/10.1007/s00280-019-03803-8
https://doi.org/10.1007/s00280-019-03803-8
Autor:
Addepalli Pavani, Rajasekar Manoj Kumar, Vijay Kumar Kutala, Shaik Mohammad Naushad, Amaresh Rao Malempati, Murali Srinath
Publikováno v:
Pharmacogenomics. 17:121-131
Aim: To develop more precise pharmacogenomic algorithm for prediction of safe and effective dose of warfarin. Materials & methods: An artificial neural network (ANN) algorithm was developed by using age, gender, BMI, plasma vitamin K levels, thyroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0617823e83182e1397867aac20e5b2df
https://doi.org/10.2217/pgs.15.161
https://doi.org/10.2217/pgs.15.161
Autor:
Shaik Mohammad Naushad, Addepalli Pavani, Vijay Kumar Kutala, Tajamul Hussain, Yedluri Rupasree, Salman A. H. Alrokayan
Publikováno v:
Pharmacological reports : PR. 71(3)
Background Effective immunosuppression through optimization of trough levels tacrolimus reduces post-transplant mortality rate in liver transplant cases. Methods Meta-analysis was carried out to evaluate how donor/recipient CYP3A5 (n = 678) and recip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d7076167e19b7082ebc3969c6443d1
https://pubmed.ncbi.nlm.nih.gov/31003147
https://pubmed.ncbi.nlm.nih.gov/31003147
Autor:
Addepalli Pavani, Krishnan Abinaya, Addepally Uma, Renganathan Gnanambal Kamakshi, Vijay Kumar Kutala, Balraj Alex Stanley, Malempati Amaresh Rao, Shaik Mohammad Naushad
Publikováno v:
Pharmacogenomics. 16:393-400
Aim: To evaluate the impact of CYP2C9*2 and CYP2C9*3 variants on binding and hydroxylation of warfarin. Materials & methods: Multiple linear regression model of warfarin pharmacokinetics was developed from the dataset of patients (n = 199). Pymol bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dcf48b60000c7beb07a2c688c75e84
https://doi.org/10.2217/pgs.14.185
https://doi.org/10.2217/pgs.14.185
Publikováno v:
Pharmacogenomics. 15:1125-1132
Aim: To ascertain whether multiple polynomial regression (MPR) has any advantage over multiple linear regression (MLR) in developing pharmacogenomic algorithms. Materials & methods: Two pharmacogenomic algorithms were developed based on MPR and MLR m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e573e8d80e66078e613a154264d954e
https://doi.org/10.2217/pgs.14.59
https://doi.org/10.2217/pgs.14.59
Autor:
Vijay Kumar Kutala, Shaik Mohammad Naushad, Amaresh Rao Malempati, Sriraman Nivetha, Balraj Alex Stanley, Ganapathy Lakshmitha, Addepalli Pavani
Publikováno v:
Pharmacogenomics. 17(12)
Aim: To investigate the influence of alterations in vitamin K (K1, K2 and K3) in modulating warfarin dose requirement. Patients & methods: Reverse phase HPLC to determine the plasma vitamin K; PCR-RFLP to detect polymorphisms; and the neuro-fuzzy mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbeddb04d655e6c26a54ac5f4ee067b1
https://pubmed.ncbi.nlm.nih.gov/27462768
https://pubmed.ncbi.nlm.nih.gov/27462768
Autor:
Yedluri Rupasree, Shaik Mohammad Naushad, Raghunadharao Digumarti, Aruna K Prayaga, Addepalli Pavani, Suryanarayana Raju Gottumukkala, Shree Divyya, Sripurna Deepti, Vijay Kumar Kutala
Publikováno v:
Molecular Carcinogenesis. 51:E32-E41
We have earlier demonstrated the role of aberrant one-carbon metabolism in the etiology of breast cancer. In the current study, we examine the clinical utility of these factors in predicting the subtype of breast cancer and as indicators of disease p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::263dba747f20815ca35ebd3a67a42642
https://doi.org/10.1002/mc.21830
https://doi.org/10.1002/mc.21830
Autor:
Shaik Mohammad Naushad, Periannan Kuppusamy, Cheruku Apoorva Reddy, Raghunadharao Digumarti, Addepalli Pavani, Yedluri Rupasree, Vijay Kumar Kutala, Suryanarayana Raju Gottumukkala
Publikováno v:
Cell Biochemistry and Biophysics. 61:715-723
The aim of this case-control study is to explore the role of aberrations in xenobiotic metabolism in inducing oxidative DNA damage and altering the susceptibility to breast cancer. Cytochrome P4501A1 (CYP1A1) m1 (OR: 1.41, 95% CI 1.08-1.84), CYP1A1 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11af479108a74f24072f4822db1eb544
https://doi.org/10.1007/s12013-011-9245-x
https://doi.org/10.1007/s12013-011-9245-x
Autor:
Addepalli Pavani, Amaresh Rao Malempati, Yedluri Rupasree, Ramakrishna Pinjala, T R Kumar, Vijay Kumar Kutala, Ramesh Chandra Mishra, Shaik Mohammad Naushad
Publikováno v:
The Pharmacogenomics Journal. 12:306-311
To optimize the warfarin dose, a population-specific pharmacogenomic algorithm was developed using multiple linear regression model with vitamin K intake and cytochrome P450 IIC polypeptide9 (CYP2C9(*)2 and (*)3), vitamin K epoxide reductase complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b30d4bd1291a3953682a1774c8b051b
https://doi.org/10.1038/tpj.2011.4
https://doi.org/10.1038/tpj.2011.4