Zobrazeno 1 - 10
of 436
pro vyhledávání: '"Adaptive trial"'
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background In clinical trials, the determination of an adequate sample size is a challenging task, mainly due to the uncertainty about the value of the effect size and nuisance parameters. One method to deal with this uncertainty is a sample
Externí odkaz:
https://doaj.org/article/665fb45aa28a4e7f8cf22244c7b7e038
Autor:
William J. Meurer, Florian F. Schmitzberger, Sharon Yeatts, Viswanathan Ramakrishnan, Benjamin Abella, Tom Aufderheide, William Barsan, Justin Benoit, Scott Berry, Joy Black, Nia Bozeman, Kristine Broglio, Jeremy Brown, Kimberly Brown, Noelle Carlozzi, Angela Caveney, Sung-Min Cho, Hangyul Chung-Esaki, Robert Clevenger, Robin Conwit, Richelle Cooper, Valentina Crudo, Mohamud Daya, Deneil Harney, Cindy Hsu, Nicholas J. Johnson, Imad Khan, Shaveta Khosla, Peyton Kline, Anna Kratz, Peter Kudenchuk, Roger J. Lewis, Chaitra Madiyal, Sara Meyer, Jarrod Mosier, Marwan Mouammar, Matthew Neth, Brian O’Neil, James Paxton, Sofia Perez, Sarah Perman, Cemal Sozener, Mickie Speers, Aimee Spiteri, Valerie Stevenson, Kavita Sunthankar, Joseph Tonna, Scott Youngquist, Romergryko Geocadin, Robert Silbergleit, ICECAP trial investigators
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Cardiac arrest is a common and devastating emergency of both the heart and brain. More than 380,000 patients suffer out-of-hospital cardiac arrest annually in the USA. Induced cooling of comatose patients markedly improved neurolo
Externí odkaz:
https://doaj.org/article/d175c8409ccf45f19bb469ca803b04d6
Autor:
Michael Dymock, Charlie McLeod, Peter Richmond, Tom Snelling, Julie A. Marsh, On behalf of the PICOBOO Investigator Team
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract The Platform trial In COVID-19 priming and BOOsting (PICOBOO) is a multi-site, adaptive platform trial designed to generate evidence of the immunogenicity, reactogenicity, and cross-protection of different booster vaccination strategies agai
Externí odkaz:
https://doaj.org/article/4dc24cdaa07b4df49dae57d117c50321
Autor:
Melissa Pyle, Lucy Loftus, Richard Emsley, Daniel Freeman, Steven Gillard, Andrew Gumley, Justyna Sierpatowska, Lisa Wood, Rory C. O’Connor, Paul Pfeiffer, Sharon Anne Simpson, Nicole Cockayne, Gemma Shields, Ariane Beckley, Helen Beckwith, Maria Filippidou, Callum Glen, Stephanie Allan, Raj Hazzard, Eleanor Longden, Heather Peel, Mark Larsen, Sandra Bucci, Anthony P. Morrison
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background People with serious mental health problems (SMHP) are more likely to be admitted to psychiatric hospital following contact with crisis services. Admissions can have significant personal costs, be traumatic and are the most expensi
Externí odkaz:
https://doaj.org/article/d8f8a6b657044f61bf7c2cdd511ad029
Autor:
Babak Choodari-Oskooei, Alexandra Blenkinsop, Kelly Handley, Thomas Pinkney, Mahesh K. B. Parmar
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Multi-arm multi-stage (MAMS) randomised trial designs have been proposed to evaluate multiple research questions in the confirmatory setting. In designs with several interventions, such as the 8-arm 3-stage ROSSINI-2 trial for pre
Externí odkaz:
https://doaj.org/article/f169275c95354f73bdb833b5346d695c
Autor:
John B. Connolly, Austin Burt, George Christophides, Abdoulaye Diabate, Tibebu Habtewold, Penelope A. Hancock, Anthony A. James, Jonathan K. Kayondo, Dickson Wilson Lwetoijera, Alphaxard Manjurano, Andrew R. McKemey, Michael R. Santos, Nikolai Windbichler, Filippo Randazzo
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Sustainable reductions in African malaria transmission require innovative tools for mosquito control. One proposal involves the use of low-threshold gene drive in Anopheles vector species, where a ‘causal pathway’ would be initiated by (
Externí odkaz:
https://doaj.org/article/b6a7d6d5b26e4dd49ad7b5d50b906a08
Publikováno v:
BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Background Numerous clinical trials have been initiated to find effective treatments for COVID-19. These trials have often been initiated in regions where the pandemic has already peaked. Consequently, achieving full enrollment in a single t
Externí odkaz:
https://doaj.org/article/10812d65e65e4c389e1f4bb251706ddc
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