Zobrazeno 1 - 10
of 599
pro vyhledávání: '"Adapter (genetics)"'
Autor:
Hemmo Meyer, Johannes van den Boom, Maike Giesing, Markus Kaiser, Dongqing Pan, Anja F Kueck, Farnusch Kaschani, Andrea Musacchio, Bojana Kravic, Helen Müschenborn
Publikováno v:
Nature Structural & Molecular Biology. 28:964-971
The AAA-ATPase VCP/p97/Cdc48 unfolds proteins by threading them through its central pore, but how substrates are recognized and inserted into the pore in diverse pathways has remained controversial. Here, we show that p97, with its adapter p37, binds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ea5df46659cf9616ab7e5d5c1125d3
https://doi.org/10.1038/s41594-021-00684-5
https://doi.org/10.1038/s41594-021-00684-5
Autor:
Chang H Byeon, Xiaohong Zhou, Simon C. Weiss, Maria DeLucia, Jinwoo Ahn, Ying Wu, Jacek Skowronski, Caili Hao, Jinwon Jung, Angela M. Gronenborn, Guillermo Calero, In-Ja L. Byeon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
HIV-1 Vpr is a prototypic member of a large family of structurally related lentiviral virulence factors that antagonize various aspects of innate antiviral immunity. It subverts host cell DNA repair and protein degradation machineries by binding and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67638a31ef774320dd6ee6001dea2c76
https://doaj.org/article/f2cad48d7439439680a1cc4a66c3934c
https://doaj.org/article/f2cad48d7439439680a1cc4a66c3934c
Autor:
Nicolas Künzel, Volkhard Helms
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 90:351-362
Members of the 14-3-3 domain family have important functions as adapter domains. Via an amphipathic groove on their protein surface they typically bind to disordered C-terminals of other proteins. Importantly, binding partners of 14-3-3 domains usual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa20342c3cbd1fcf6a4ea5c7e04616c
https://doi.org/10.1002/prot.26224
https://doi.org/10.1002/prot.26224
Autor:
Brendan O'Connell, Rosalie C. Sears, Frank J. Steemers, Brian J. O'Roak, Andrew Adey, Ryan M. Mulqueen, Casey A. Thornton, Galip Gürkan Yardımcı, Dmitry K. Pokholok, Jason Link, Fan Zhang
Publikováno v:
Nature biotechnology
Single-cell genomics assays have emerged as a dominant platform for interrogating complex biological systems. Methods to capture various properties at the single-cell level typically suffer a tradeoff between cell count and information content, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b0e12b8aa035bd5e0242804c99517d
https://doi.org/10.1038/s41587-021-00962-z
https://doi.org/10.1038/s41587-021-00962-z
Autor:
Maria E. Lopatkina, Maria I. Yablonskaya, Emil Valeev, Nadezhda V. Shilova, Veniamin S. Fishman, M.M. Gridina, Zhanna G. Markova, I. N. Lebedev, Viktoria Yu Voinova, Ludmila P. Nazarenko, Evgeniy A. Mozheiko
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-15 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background The Hi-C technique is widely employed to study the 3-dimensional chromatin architecture and to assemble genomes. The conventional in situ Hi-C protocol employs restriction enzymes to digest chromatin, which results in nonuniform genomic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f26674afa899d89a8e63a51c2f596c9
https://doaj.org/article/fec92906eb854cc3a364233c77852460
https://doaj.org/article/fec92906eb854cc3a364233c77852460
Publikováno v:
RNA
Noncoding RNAs regulate gene expression in every domain of life. In bacteria, small RNAs (sRNAs) regulate gene expression in response to stress and are often assisted by RNA–chaperone proteins, such as Hfq. We have recently developed a bacterial th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eddbafd2936767369a0e241ec61b8c5
https://doi.org/10.1261/rna.077404.120
https://doi.org/10.1261/rna.077404.120
TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics
Autor:
Marco Potowski, Alexander Dömling, Mateja Klika Škopić, Blaž Andlovic, Shabnam Shaabani, Roland Fried, Mohammad Akbarzadeh, Matthew Groves, Denise Dos Santos Smith, Hélène Adihou, Constantinos G. Neochoritis, Hacer Karatas, Andreas Brunschweiger, Tryfon Zarganes-Tzitzikas, Ran Zhang, Christian Ottmann, Verena B. K. Kunig, Stéphanie M. Guéret, Lukas Arendt, Jörg Rahnenführer, Ina Dormuth
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 59(46), 20338-20342. Wiley
Angewandte Chemie (International ed. in English), 59(46), 20338-20342. WILEY-V C H VERLAG GMBH
Angewandte Chemie, 132(46), 20518-20522. Wiley-VCH Verlag
Angewandte Chemie International Edition
Angewandte Chemie-International Edition, 59(46), 20338-20342. Wiley
Angewandte Chemie (International ed. in English), 59(46), 20338-20342. WILEY-V C H VERLAG GMBH
Angewandte Chemie, 132(46), 20518-20522. Wiley-VCH Verlag
Angewandte Chemie International Edition
DNA-encoded combinatorial synthesis provides efficient and dense coverage of chemical space around privileged molecular structures. The indole side chain of tryptophan plays a prominent role in key, or ���hot spot���, regions of protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d406dc03f9c692763406bf3b95e514
https://research.rug.nl/en/publications/bad0555f-29a6-4aed-9e54-6c9780944773
https://research.rug.nl/en/publications/bad0555f-29a6-4aed-9e54-6c9780944773
Publikováno v:
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 5:293-299
RATIONALE: Facemasks are commonly used by certain patients requiring assistance for aerosol medication delivery. Adapters are used as connectors between facemasks and inhalers. The valved holding c...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd78830e16053e9f9dca84dd2abffa35
https://doi.org/10.1080/24745332.2020.1787112
https://doi.org/10.1080/24745332.2020.1787112
Autor:
Joshua A. Kritzer, Jennifer R. Pace, Hawley F. Brown, Robert A. Cerulli, Livia Shehaj, Yang Mei
Publikováno v:
Chembiochem
A growing body of evidence suggests that autophagy inhibition enhances the effectiveness of chemotherapy, especially in difficult-to-treat cancers. Existing autophagy inhibitors are primarily lysosomotropic agents. More specific autophagy inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b068ef6b388b98a96f0180d799b05a7
https://doi.org/10.1002/cbic.202000212
https://doi.org/10.1002/cbic.202000212
Autor:
Andreas Buchbender, F. X. Reymond Sutandy, Heike Hänel, Nadine Körtel, Holger Mutter, Stefanie Ebersberger, Anke Busch, Julian König
Publikováno v:
Methods. 178:33-48
Individual-nucleotide resolution UV crosslinking and immunoprecipitation (iCLIP) is a state-of-the-art technology to map the RNA interaction sites of an RNA-binding protein (RBP) across the transcriptome. Here, we present the new iCLIP2 protocol that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f95c44c5916d581af7808a7758683d8
https://doi.org/10.1016/j.ymeth.2019.10.003
https://doi.org/10.1016/j.ymeth.2019.10.003