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Development of Machine Learning Classifiers for Blood-based Diagnosis and Prognosis of Suspected Acute Infections and Sepsis

Autor: Buturovic, Ljubomir, Mayhew, Michael, Luethy, Roland, Choi, Kirindi, Midic, Uros, Damaraju, Nandita, Hasin-Brumshtein, Yehudit, Pratap, Amitesh, Adams, Rhys M., Fonseca, Joao, Srinath, Ambika, Fleming, Paul, Pereira, Claudia, Liesenfeld, Oliver, Khatri, Purvesh, Sweeney, Timothy

We applied machine learning to the unmet medical need of rapid and accurate diagnosis and prognosis of acute infections and sepsis in emergency departments. Our solution consists of a Myrna (TM) Instrument and embedded TriVerity (TM) classifiers. The

Externí odkaz: http://arxiv.org/abs/2407.02737

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Physical epistatic landscape of antibody binding affinity

Autor: Adams, Rhys M., Kinney, Justin B., Walczak, Aleksandra M., Mora, Thierry

Publikováno v: Cell Systems 8 86-93 (2019)

Affinity maturation produces antibodies that bind antigens with high specificity by accumulating mutations in the antibody sequence. Mapping out the antibody-antigen affinity landscape can give us insight into the accessible paths during this rapid e

Externí odkaz: http://arxiv.org/abs/1712.04000

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Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves

Autor: Adams, Rhys M., Mora, Thierry, Walczak, Aleksandra M., Kinney, Justin B.

Publikováno v: eLife 2016;5:e23156 (2016)

Despite the central role that antibodies play in the adaptive immune system and in biotechnology, much remains unknown about the quantitative relationship between an antibody's amino acid sequence and its antigen binding affinity. Here we describe a

Externí odkaz: http://arxiv.org/abs/1601.02160

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La participation d'étudiantes et d'étudiants en classe d'apprentissage actif vue à travers leurs artefacts épistémiques physiques

Autor: Charles, Elizabeth S., Lenton, Kevin, Dugdale, Michael, Lasry, Nathaniel, Zhang, Chao, Whittaker, Chris, Adams, Rhys

Publikováno v: Revue internationale du CRIRES : innover dans la tradition de Vygotsky. 6:31-51

Les artefacts épistémiques de nature physique sont les preuves matérielles du travail effectué et produit par les étudiant·es dans le cadre de leur apprentissage. Selon la théorie socioculturelle, ils sont susceptibles de servir de médiateurs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d327abae2b3f5f8bedf71baab8c9fc
https://doi.org/10.51657/ric.v6i1.51520