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SHP2: A Pleiotropic Target at the Interface of Cancer and Its Microenvironment.

Autor: Sodir NM; Department of Translational Oncology, Genentech, South San Francisco, California., Pathria G; Department of Oncology Biomarker Development, Genentech, South San Francisco, California., Adamkewicz JI; Program Strategy and Management, Genentech, South San Francisco, California., Kelley EH; Department of Discovery Chemistry, Genentech, South San Francisco, California., Sudhamsu J; Department of Structural Biology, Genentech, South San Francisco, California., Merchant M; Department of Translational Oncology, Genentech, South San Francisco, California., Chiarle R; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy., Maddalo D; Department of Translational Oncology, Genentech, South San Francisco, California.

Publikováno v: Cancer discovery [Cancer Discov] 2023 Nov 01; Vol. 13 (11), pp. 2339-2355.

Effect of emicizumab prophylaxis on bone and joint health markers in people with haemophilia A without factor VIII inhibitors in the HAVEN 3 study.

Autor: Kiialainen A; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Niggli M; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Kempton CL; Hemophilia of Georgia Center for Bleeding & Clotting Disorders of Emory, Emory University School of Medicine, Atlanta, Georgia, USA., Castaman G; Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Florence, Italy., Chang T; Genentech, Inc., South San Francisco, California, USA.; Graphite Bio, Inc., South San Francisco, California, USA., Paz-Priel I; Genentech, Inc., South San Francisco, California, USA.; Spark Therapeutics, Inc., Philadelphia, Pennsylvania, USA., Adamkewicz JI; Genentech, Inc., South San Francisco, California, USA., Levy GG; Genentech, Inc., South San Francisco, California, USA.; Graphite Bio, Inc., South San Francisco, California, USA.

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2022 Nov; Vol. 28 (6), pp. 1033-1043. Date of Electronic Publication: 2022 Jul 29.

Effects and interferences of emicizumab, a humanized bispecific antibody mimicking activated factor VIII cofactor function, on lupus anticoagulant assays.

Autor: Adamkewicz JI; Genentech, Inc., South San Francisco, CA, USA., Kiialainen A; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Paz-Priel I; Genentech, Inc., South San Francisco, CA, USA.

Publikováno v: International journal of laboratory hematology [Int J Lab Hematol] 2020 Apr; Vol. 42 (2), pp. e71-e75. Date of Electronic Publication: 2019 Oct 31.

Emicizumab Prophylaxis in Patients Who Have Hemophilia A without Inhibitors.

Autor: Mahlangu J; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Oldenburg J; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Paz-Priel I; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Negrier C; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Niggli M; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Mancuso ME; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Schmitt C; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Jiménez-Yuste V; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Kempton C; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Dhalluin C; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Callaghan MU; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Bujan W; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Shima M; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Adamkewicz JI; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Asikanius E; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Levy GG; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.)., Kruse-Jarres R; From the Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg (J.M.); Universitätsklinikum Bonn, Bonn, Germany (J.O.); Genentech, South San Francisco, CA (I.P.-P., J.I.A., G.G.L.); Louis Pradel University Hospital, Lyon, France (C.N.); F. Hoffmann-La Roche, Basel, Switzerland (M.N., C.S., C.D., E.A.); Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan (M.E.M.); the Hematology Department, Hospital Universitario La Paz, Autónoma University, Madrid (V.J.-Y.); the Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta (C.K.); Children's Hospital of Michigan, Detroit (M.U.C.); Instituto Costarricense de Investigaciones Científicas, San José, Costa Rica (W.B.); the Department of Pediatrics, Nara Medical University, Kashihara, Japan (M.S.); and the Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle (R.K.-J.).

Publikováno v: The New England journal of medicine [N Engl J Med] 2018 Aug 30; Vol. 379 (9), pp. 811-822.