Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Adamantios, Mamais"'
Autor:
Jean-Marc Taymans, Matt Fell, Tim Greenamyre, Warren D. Hirst, Adamantios Mamais, Shalini Padmanabhan, Inga Peter, Hardy Rideout, Avner Thaler
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Almost 2 decades after linking LRRK2 to Parkinson’s disease, a vibrant research field has developed around the study of this gene and its protein product. Recent studies have begun to elucidate molecular structures of LRRK2 and its complex
Externí odkaz:
https://doaj.org/article/ca18d0b49bf042a49e27c3300dadea0f
Autor:
Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Thomas Warner, John Hardy, Patrick A. Lewis, Jennifer Pocock, Mark R. Cookson, Rina Bandopadhyay
Publikováno v:
Cells, Vol 13, Iss 1, p 53 (2023)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause autosomal dominant Parkinson’s disease (PD), with the most common causative mutation being the LRRK2 p.G2019S within the kinase domain. LRRK2 protein is highly expressed in the human
Externí odkaz:
https://doaj.org/article/fd1712ee720f403b97f1792cb7f73082
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105721- (2022)
In recent years progress in molecular biology and genetics have advanced our understanding of neurological disorders and highlighted synergistic relationships with inflammatory and age-related processes. Parkinson’s disease (PD) is a common neurode
Externí odkaz:
https://doaj.org/article/9b9ef845038a469aaabe13b76784398c
Autor:
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Kirsten Harvey, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David C Gershlick, Mark R Cookson
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001621 (2022)
[This corrects the article DOI: 10.1371/journal.pbio.3001480.].
Externí odkaz:
https://doaj.org/article/0cfb6188812b44e8a7612e5d6a062027
Autor:
Jillian H. Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A. Lewis, Mark R. Cookson, Adamantios Mamais
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-19 (2021)
Abstract The most common mutation in the Leucine-rich repeat kinase 2 gene (LRRK2), G2019S, causes familial Parkinson’s Disease (PD) and renders the encoded protein kinase hyperactive. While targeting LRRK2 activity is currently being tested in cli
Externí odkaz:
https://doaj.org/article/52ef7f0af69a412e95a2ef217da36658
Autor:
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David C Gershlick, Mark R Cookson
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001480 (2021)
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicity in vitro
Externí odkaz:
https://doaj.org/article/71c689db45394c029f869d5ffc9ae238
Autor:
Isabella Russo, Alice Kaganovich, Jinhui Ding, Natalie Landeck, Adamantios Mamais, Tatiana Varanita, Alice Biosa, Isabella Tessari, Luigi Bubacco, Elisa Greggio, Mark R. Cookson
Publikováno v:
Neurobiology of Disease, Vol 129, Iss , Pp 67-78 (2019)
Several previous studies have linked the Parkinson's disease (PD) gene LRRK2 to the biology of microglia cells. However, the precise ways in which LRRK2 affects microglial function have not been fully resolved. Here, we used the RNA-Sequencing to obt
Externí odkaz:
https://doaj.org/article/6c52926ffb4e4d618de34aace75d741d
Autor:
George R. Heaton, Natalie Landeck, Adamantios Mamais, Mike A. Nalls, Jonathon Nixon-Abell, Ravindran Kumaran, Alexandra Beilina, Laura Pellegrini, Yan Li, Kirsten Harvey, Mark R. Cookson
Publikováno v:
Neurobiology of Disease, Vol 141, Iss , Pp 104948- (2020)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are an established cause of inherited Parkinson's disease (PD). LRRK2 is expressed in both neurons and glia in the central nervous system, but its physiological function(s) in each of these cell types
Externí odkaz:
https://doaj.org/article/269f392a74f74455bdede54a390324cd
Autor:
Alexandra Beilina, Luis Bonet-Ponce, Ravindran Kumaran, Jennifer J. Kordich, Morié Ishida, Adamantios Mamais, Alice Kaganovich, Sara Saez-Atienzar, David C. Gershlick, Dorien A. Roosen, Laura Pellegrini, Vlad Malkov, Matthew J. Fell, Kirsten Harvey, Juan S. Bonifacino, Darren J. Moore, Mark R. Cookson
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). However, the precise function of LRRK2 remains unclear. We report an interaction between LRRK2 and VPS52, a subunit of the Golgi-associated retrograde protei
Externí odkaz:
https://doaj.org/article/8f3645a2b68b47bab2889e3c6b78354d
Autor:
David N. Hauser, Adamantios Mamais, Melissa M. Conti, Christopher T. Primiani, Ravindran Kumaran, Allissa A. Dillman, Rebekah G. Langston, Alexandra Beilina, Joseph H. Garcia, Alberto Diaz-Ruiz, Michel Bernier, Fabienne C. Fiesel, Xu Hou, Wolfdieter Springer, Yan Li, Rafael de Cabo, Mark R. Cookson
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-17 (2017)
Abstract Background Early onset Parkinson’s disease is caused by variants in PINK1, parkin, and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity, but the function of DJ-1 and how it relates to PINK1 and parkin is poo
Externí odkaz:
https://doaj.org/article/dfb1e3bfdb1b4d30a14773c86e3340df