Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Adam Waickman"'
Autor:
Kerri G. Lal, Yuwadee Phuang-Ngern, Suchada Suhkumvittaya, Edwin Leeansyah, Aljawharah Alrubayyi, Joana Dias, Adam Waickman, Dohoon Kim, Eugène Kroon, Suteeraporn Pinyakorn, Leigh Anne Eller, Milton Maciel Jr., Rungsun Rerknimitr, Nitiya Chomchey, Nittaya Phanuphak, Mark S. de Souza, Sorachai Nitayaphan, Julie A. Ake, Sandhya Vasan, Merlin L. Robb, Jintanat Ananworanich, Johan K. Sandberg, Alexandra Schuetz, Michael A. Eller, Dominic Paquin-Proulx, on behalf of the RV217, RV254/SEARCH010, RV304/SEARCH Study Groups
Publikováno v:
Viruses, Vol 12, Iss 12, p 1426 (2020)
CD161 expression on CD4+ T cells is associated with a Th17 functional phenotype, as well as with an innate capacity to respond to interleukin (IL)-12 and IL-18 without T cell receptor (TCR) stimulation. Chronic HIV-1 infection is associated with loss
Externí odkaz:
https://doaj.org/article/1e1c3a125b8c43278f4a9a15b2209438
Autor:
Sam Collins, Adam Waickman, Albert Basson, Abraham Kupfer, Jonathan D Licht, Maureen R Horton, Jonathan D Powell
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49801 (2012)
TCR-induced NF-AT activation leads to the expression of both activating and inhibitory proteins. Previously, we had identified Egr-2 and Egr-3 as NF-AT-induced transcription factors which promote the inhibition of T cell activation. In this report we
Externí odkaz:
https://doaj.org/article/16e44b9a4e1a4b13a5ae054cc44c060d
Autor:
Emily Heikamp, Chirag Patel, Sam Collins, Adam Waickman, Archna Scharma, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Jyoti Sen, Maureen Horton, Jonathan Powell
Publikováno v:
The Journal of Immunology. 190:50.23-50.23
The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of T cell differentiation. mTOR integrates various signals in the immune microenvironment, including costimulatory ligands, cytokines, and the availability of nutrients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32b55f9a5024d37fba36795ec54e63d1
https://doi.org/10.4049/jimmunol.190.supp.50.23
https://doi.org/10.4049/jimmunol.190.supp.50.23
Publikováno v:
The Journal of Immunology. 186:46.20-46.20
Recent studies implicate mTOR in the generation of CD8+ T cell memory. Here, we demonstrate that mTORC1 is required for CD8+ T cell effector function during the activation of naïve CD8+ T cells. We generated mouse T cell-specific knockouts of Rheb,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a097dadab4fd94f05246d7e21012149
https://doi.org/10.4049/jimmunol.186.supp.46.20
https://doi.org/10.4049/jimmunol.186.supp.46.20
Autor:
Adam Waickman, Jonathan Powell
Publikováno v:
The Journal of Immunology. 184:132.13-132.13
The A2A adenosine receptor (A2A AR) plays a critical role in regulating immune system activation and tolerance. We hypothesized that A2AR blockade would enhance T cell responses to viral infection. Indeed, A2A AR-/- T cells demonstrate increased expa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::319bc2bdb2cab2e298d16bfcdfc214aa
https://doi.org/10.4049/jimmunol.184.supp.132.13
https://doi.org/10.4049/jimmunol.184.supp.132.13
Publikováno v:
The Journal of Immunology. 184:132.14-132.14
Recent studies implicate mTOR activity in the generation of memory CD8+ T cells. Tuberous Sclerosis Complex 2 gene (TSC2) is an upstream inhibitor of mTOR function. In this report, mice in which TSC2 is deleted in T cells were utilized to determine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9021a7cf956f4865868d8de5cc1e7bc6
https://doi.org/10.4049/jimmunol.184.supp.132.14
https://doi.org/10.4049/jimmunol.184.supp.132.14
Publikováno v:
The Journal of Immunology. 184:131.3-131.3
Adenosine, acting via the A2A adenosine receptor (A2aR), is emerging as an important inhibitor of immune function. Indeed, the tumor microenvironment contains relatively high levels of adenosine suggesting that tumor-derived adenosine is one mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ce927d2908dc2ee9c9916c6dc409f63
https://doi.org/10.4049/jimmunol.184.supp.131.3
https://doi.org/10.4049/jimmunol.184.supp.131.3
Publikováno v:
The Journal of Immunology. 184:50.35-50.35
The mammalian target of rapamycin (mTOR) is a highly conserved serine-threonine kinase that regulates cell division, survival, and translation. Downstream mTOR signals via two functionally distinct complexes, TORC1 and TORC2. We have previously shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52e10df53703f7f402fe4acc9cbf5f9e
https://doi.org/10.4049/jimmunol.184.supp.50.35
https://doi.org/10.4049/jimmunol.184.supp.50.35