Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Adam W. Clemens"'
Publikováno v:
bioRxiv
SummaryDuring postnatal development the DNA methyltransferase DNMT3A deposits high levels of non-CG cytosine methylation in neurons. This unique methylation is critical for transcriptional regulation in the mature mammalian brain, and loss of this ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e9adeebb93fef0b651d385262f4597
https://europepmc.org/articles/PMC9949142/
https://europepmc.org/articles/PMC9949142/
Autor:
Nicole Hamagami, Dennis Y. Wu, Adam W. Clemens, Sabin A. Nettles, Aidan Li, Harrison W. Gabel
Publikováno v:
Molecular Cell. 83:1412-1428.e7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::494c8b53d485c454b02de5c03730b18a
https://doi.org/10.1016/j.molcel.2023.04.001
https://doi.org/10.1016/j.molcel.2023.04.001
Autor:
Amanda, Dicks, Himanshi, Bhatia, Adam W, Clemens, Marissa C, Locke, Elizabeth A, Mueller, Daniel, Murphy, Nathan, Pomper, Anne E, Robinson, Kathleen M, Schoch
Publikováno v:
Nature biotechnology. 39(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bad927906ff01b9633e5738bab5e1b57
https://pubmed.ncbi.nlm.nih.gov/34621067
https://pubmed.ncbi.nlm.nih.gov/34621067
Autor:
Harrison W. Gabel, Adam W. Clemens
Publikováno v:
Trends Genet
The genomes of mammalian neurons are enriched for unique forms of DNA methylation, including exceptionally high levels of non-CG methylation. Here, we review recent studies defining how non-CG methylation accumulates in neurons and is read out by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f53ca8c6627f0d03272b0fc135cd6f
https://europepmc.org/articles/PMC7572801/
https://europepmc.org/articles/PMC7572801/
Autor:
Joseph D. Dougherty, Adam W. Clemens, Jenna R. Martin, Y. Liu, Nicole M. Kirkland, Sabin A. Nettles, J. Russell Moore, Cheryl A. Hill, David F. Wozniak, Diana L. Christian, Harrison W. Gabel, Dennis Y. Wu
SummaryMutations in DNA methyltransferase 3A (DNMT3A) have been detected in autism and related disorders, but how these mutations disrupt nervous system function is unknown. Here we define the effects of neurodevelopmental disease-associated DNMT3A m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87e6b4bbf07447be55610a1a38fbe3dc
https://doi.org/10.1101/2020.07.10.195859
https://doi.org/10.1101/2020.07.10.195859
Autor:
Dennis Y. Wu, Jenna R. Martin, David F. Wozniak, Thomas Papouin, Sabin A. Nettles, Joseph D. Dougherty, Cheryl A. Hill, J. Russell Moore, Adam W. Clemens, Diana L. Christian, Y. Liu, Harrison W. Gabel, Nicole M. Kirkland
Publikováno v:
Cell reports
SUMMARY Mutations in DNA methyltransferase 3A (DNMT3A) have been detected in autism and related disorders, but how these mutations disrupt nervous system function is unknown. Here, we define the effects of DNMT3A mutations associated with neurodevelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e5e6ea4b5612b4ecf7cd96996e77df
https://doi.org/10.1016/j.celrep.2020.108416
https://doi.org/10.1016/j.celrep.2020.108416
Autor:
Harrison W. Gabel, J. Russell Moore, Guoyan Zhao, Adam W. Clemens, Dennis Y. Wu, Diana L. Christian
Publikováno v:
Mol Cell
The genomes of mammalian neurons contain uniquely high levels of non-CG DNA methylation that can be bound by the Rett syndrome protein, MeCP2, to regulate gene expression. How patterns of non-CG methylation are established in neurons and the mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f0e3d5576342288cf66eb39ee09ebb
https://doi.org/10.1016/j.molcel.2019.10.033
https://doi.org/10.1016/j.molcel.2019.10.033
Publikováno v:
BMC Plant Biology
Background The Arabidopsis thaliana LEC2 gene encodes a B3 domain transcription factor, which plays critical roles during both zygotic and somatic embryogenesis. LEC2 exerts significant impacts on determining embryogenic potential and various metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d6dd37c3716ddafb465b82e6cc2530
https://pubmed.ncbi.nlm.nih.gov/24758406
https://pubmed.ncbi.nlm.nih.gov/24758406