Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Adam W Whisnant"'
Autor:
Xiuye Wang, Liang Liu, Adam W Whisnant, Thomas Hennig, Lara Djakovic, Nabila Haque, Cindy Bach, Rozanne M Sandri-Goldin, Florian Erhard, Caroline C Friedel, Lars Dölken, Yongsheng Shi
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009263 (2021)
Eukaryotic gene expression is extensively regulated by cellular stress and pathogen infections. We have previously shown that herpes simplex virus 1 (HSV-1) and several cellular stresses cause widespread disruption of transcription termination (DoTT)
Externí odkaz:
https://doaj.org/article/2e679acc20f04b73be31b6e85ae139cc
Autor:
Marco R Rink, Marisa A P Baptista, Felix J Flomm, Thomas Hennig, Adam W Whisnant, Natalia Wolf, Jürgen Seibel, Lars Dölken, Jens B Bosse
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0244166 (2021)
Fluorogenic aptamers are an alternative to established methodology for real-time imaging of RNA transport and dynamics. We developed Broccoli-aptamer concatemers ranging from 4 to 128 substrate-binding site repeats and characterized their behavior fu
Externí odkaz:
https://doaj.org/article/3179583d0e394143b1db375ef4588a2b
Autor:
Bhupesh K Prusty, Adam W Whisnant
Publikováno v:
eLife, Vol 9 (2020)
Combining integrative genomics and systems biology approaches has revealed new and conserved features in the genome of human herpesvirus 6.
Externí odkaz:
https://doaj.org/article/8d6853d2c9964ababf7f2cf7d04991b2
Autor:
Thomas Hennig, Marco Michalski, Andrzej J Rutkowski, Lara Djakovic, Adam W Whisnant, Marie-Sophie Friedl, Bhaskar Anand Jha, Marisa A P Baptista, Anne L'Hernault, Florian Erhard, Lars Dölken, Caroline C Friedel
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006954 (2018)
Lytic herpes simplex virus 1 (HSV-1) infection triggers disruption of transcription termination (DoTT) of most cellular genes, resulting in extensive intergenic transcription. Similarly, cellular stress responses lead to gene-specific transcription d
Externí odkaz:
https://doaj.org/article/0b734ce74d4b448b8f8c6a89158cb1cf
Autor:
Lara Djakovic, Thomas Hennig, Katharina Reinisch, Andrea Milić, Adam W. Whisnant, Katharina Wolf, Elena Weiß, Tobias Haas, Arnhild Grothey, Christopher S. Jürges, Michael Kluge, Elmar Wolf, Florian Erhard, Caroline C. Friedel, Lars Dölken
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection, but not upon salt or heat stress, this is accompanied by a dramatic increase in chromatin acce
Externí odkaz:
https://doaj.org/article/88c94da7658643c8abd946d207f3dd82
Autor:
Elena Weiß, Thomas Hennig, Pilar Graßl, Lara Djakovic, Adam W. Whisnant, Christopher S. Jürges, Franziska Koller, Michael Kluge, Florian Erhard, Lars Dölken, Caroline C. Friedel
Publikováno v:
Journal of Virology. 97
This study provides a genome-wide analysis of changes in promoter-proximal polymerase II (Pol II) pausing on host genes induced by HSV-1 infection. It shows that standard measures of pausing, i.e., pausing indices, do not properly capture the complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a95824fa5a9e093b9919761a44ba7b8f
https://doi.org/10.1128/jvi.00381-23
https://doi.org/10.1128/jvi.00381-23
Autor:
Elena Weiß, Thomas Hennig, Pilar Graßl, Lara Djakovic, Adam W. Whisnant, Christopher S. Jürges, Franziska Koller, Michael Kluge, Florian Erhard, Lars Dölken, Caroline C. Friedel
Herpes simplex virus 1 (HSV-1) infection exerts a profound shut-off of host gene expression at multiple levels. Recently, HSV-1 infection was reported to also impact promoter-proximal RNA Polymerase II (Pol II) pausing, a key step in the eukaryotic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b226763a037d5615b903f7f27c8503a
https://doi.org/10.1101/2022.09.28.509911
https://doi.org/10.1101/2022.09.28.509911
Autor:
Marie-Sophie Friedl, Lara Djakovic, Michael Kluge, Thomas Hennig, Adam W. Whisnant, Simone Backes, Lars Dölken, Caroline C. Friedel
Publikováno v:
PloS one. 17(10)
The herpes simplex virus 1 (HSV-1) virion host shut-off (vhs) protein cleaves both cellular and viral mRNAs by a translation-initiation-dependent mechanism, which should spare circular RNAs (circRNAs). Here, we show that vhs-mediated degradation of l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840997383ab95df1b79751e755140843
https://pubmed.ncbi.nlm.nih.gov/36279270
https://pubmed.ncbi.nlm.nih.gov/36279270
Autor:
Thomas Hennig, Archana B. Prusty, Benedikt B. Kaufer, Adam W. Whisnant, Manivel Lodha, Antje Enders, Julius Thomas, Francesca Kasimir, Arnhild Grothey, Teresa Klein, Stefanie Herb, Christopher Jürges, Markus Sauer, Utz Fischer, Thomas Rudel, Gunter Meister, Florian Erhard, Lars Dölken, Bhupesh K. Prusty
Publikováno v:
Nature
Herpesviruses have mastered host cell modulation and immune evasion to augment productive infection, life-long latency and reactivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122c54c90e9ed0b42034817058bcbf3e
Autor:
Andrea Milic, Katharina Wolf, Elmar Wolf, Katharina Reinisch, Caroline C. Friedel, Michael Kluge, Christopher Juerges, Lars Dölken, Lara Djakovic, Florian Erhard, Thomas Hennig, Adam W. Whisnant, Elena Weiß, Arnhild Grothey, Tobias Haas
Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection but not upon salt or heat stress, this is accompanied by a dramatic increase in chromatin accessibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16a3f251e10f836d52cdcf1320c40331
https://doi.org/10.21203/rs.3.rs-998249/v1
https://doi.org/10.21203/rs.3.rs-998249/v1