Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells

Autor: Martin K. Bakht, John J. Hayward, Farsheed Shahbazi-Raz, Magdalena Skubal, Ryo Tamura, Keith F. Stringer, Daniel Meister, Varadha Balaji Venkadakrishnan, Hui Xue, Adam Pillon, Mathew Stover, Adam Tronchin, Bre-Anne Fifield, Lavleen Mader, Sheng-Yu Ku, Gi Jeong Cheon, Keon Wook Kang, Yuzhuo Wang, Xuesen Dong, Himisha Beltran, Jan Grimm, Lisa A. Porter, John F. Trant

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Chemistry and Biochemistry Publications

Significance Glutamate-ureido-lysine (GUL) probes are specific for prostate-specific membrane antigen (PSMA), overexpressed by most prostate cancers. This antigen can be lost as the cancer progresses. Recent reports have indicated that GUL probes can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a29268542be1bc9269592b99513706d
https://doi.org/10.1073/pnas.2025710119

Identifying Potential Off-Target Protein Binders of Glutamate-Ureido-Lysine, a Prostate Cancer Specific Imaging Agent

Autor: Farsheed Shahbazi-Raz, Sheng-Yu Ku, Adam Pillon, Himisha Beltran, John J. Hayward, John F. Trant, Xuesen Dong, Keon Wook Kang, Lavleen Mader, Mathew Stover, Mohamadreza K. Bakht, Bre Anne Fifield, Daniel Meister, Yuzhuo Wang, Gi Jeong Cheon, Adam Tronchin, Lisa A. Porter

Prostate-specific membrane antigen (PSMA) is highly overexpressed in most prostate cancers and is clinically visualized using PSMA-specific probes incorporating Glutamate-Ureido-Lysine (GUL). PSMA is effectively absent from certain high-mortality, tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f5fb673f217e355018b64d4584f8079
https://doi.org/10.26434/chemrxiv.13064186.v3