Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Adam Thean Chor Leow"'
Autor:
Muganti Rajah Kumar, Swee Keong Yeap, Nurul Elyani Mohamad, Janna Ong Abdullah, Mas Jaffri Masarudin, Melati Khalid, Adam Thean Chor Leow, Noorjahan Banu Alitheen
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-15 (2021)
Abstract Background In recent years, researchers are interested in the discovery of active compounds from traditional remedies and natural sources, as they reveal higher therapeutic efficacies and improved toxicological profiles. Among the various tr
Externí odkaz:
https://doaj.org/article/a2a71d15e71e40cf8b3d02606b096f95
Autor:
Norhayati Yaacob, Nor Hafizah Ahmad Kamarudin, Adam Thean Chor Leow, Abu Bakar Salleh, Raja Noor Zaliha Raja Abd Rahman, Mohd Shukuri Mohamad Ali
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 215-228 (2019)
Pseudomonas fluorescens AMS8 lipase lid 1 structure is rigid and holds unclear roles due to the absence of solvent-interactions. Lid 1 region was stabilized by 17 hydrogen bond linkages and displayed lower mean hydrophobicity (0.596) compared to MIS3
Externí odkaz:
https://doaj.org/article/9a111d7306ac4897b311a802553f43b7
Autor:
Siti Nor Hasmah Ishak, Nor Hafizah Ahmad Kamarudin, Mohd Shukuri Mohamad Ali, Adam Thean Chor Leow, Fairolniza Mohd Shariff, Raja Noor Zaliha Raja Abd Rahman
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0251751 (2021)
5M mutant lipase was derived through cumulative mutagenesis of amino acid residues (D43E/T118N/E226D/E250L/N304E) of T1 lipase from Geobacillus zalihae. A previous study revealed that cumulative mutations in 5M mutant lipase resulted in decreased the
Externí odkaz:
https://doaj.org/article/a6311ef662d240fda9ebf3a5cb717ee1
Autor:
Muganti Rajah Kumar, Nor Farahin Azizi, Swee Keong Yeap, Janna Ong Abdullah, Melati Khalid, Abdul Rahman Omar, Mohd. Azuraidi Osman, Adam Thean Chor Leow, Sharifah Alawieyah Syed Mortadza, Noorjahan Banu Alitheen
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 883 (2022)
The focus on managing Alzheimer’s disease (AD) is shifting towards prevention through lifestyle modification instead of treatments since the currently available treatment options are only capable of providing symptomatic relief marginally and resul
Externí odkaz:
https://doaj.org/article/9da82e93f7f1497cb393ab84eb8352af
Autor:
Ayokunmi Omolola Oyeleye, Siti Faridah Mohd Yusoff, Izzah Nadiah Abd Rahim, Adam Thean Chor Leow, Noor Baity Saidi, Yahaya M Normi
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241074 (2020)
Conventional refolding methods are associated with low yields due to misfolding and high aggregation rates or very dilute proteins. In this study, we describe the optimization of the conventional methods of reverse dilution and affinity chromatograph
Externí odkaz:
https://doaj.org/article/f6df921b130c455da9298beab4b1f1b5
Autor:
Muganti Rajah Kumar, Swee Keong Yeap, Han Chung Lee, Nurul Elyani Mohamad, Muhammad Nazirul Mubin Aziz, Melati Khalid, Mas Jaffri Masarudin, Adam Thean Chor Leow, Janna Ong Abdullah, Noorjahan Banu Alitheen
Publikováno v:
Antioxidants, Vol 10, Iss 6, p 940 (2021)
Kefir, a fermented probiotic drink was tested for its potential anti-oxidative, anti-apoptotic, and neuroprotective effects to attenuate cellular oxidative stress on human SH-SY5Y neuroblastoma cells. Here, the antioxidant potentials of the six diffe
Externí odkaz:
https://doaj.org/article/483d2230146840f1b59bc0d7a7eb4d92
Autor:
Nurul Nadirah Ahmad, Nor Hafizah Ahmad Kamarudin, Adam Thean Chor Leow, Raja Noor Zaliha Raja Abd. Rahman
Publikováno v:
Molecules, Vol 25, Iss 17, p 3858 (2020)
Surface charge residues have been recognized as one of the stability determinants in protein. In this study, we sought to compare and analyse the stability and conformational dynamics of staphylococcal lipase mutants with surface lysine mutation usin
Externí odkaz:
https://doaj.org/article/0632759b5bb74a259c45c63a0e553f65
Autor:
Siti Nor Hasmah Ishak, Nor Hafizah Ahmad Kamarudin, Mohd Shukuri Mohamad Ali, Adam Thean Chor Leow, Raja Noor Zaliha Raja Abd. Rahman
Publikováno v:
Molecules, Vol 25, Iss 15, p 3430 (2020)
A comparative structure analysis between space- and an Earth-grown T1 recombinant lipase from Geobacillus zalihae had shown changes in the formation of hydrogen bonds and ion-pair interactions. Using the space-grown T1 lipase validated structure havi
Externí odkaz:
https://doaj.org/article/74b95a66400d4a3086467faa19474ca1
Autor:
Noramirah Bukhari, Adam Thean Chor Leow, Raja Noor Zaliha Raja Abd Rahman, Fairolniza Mohd Shariff
Publikováno v:
Molecules, Vol 25, Iss 15, p 3433 (2020)
Rational design is widely employed in protein engineering to tailor wild-type enzymes for industrial applications. The typical target region for mutation is a functional region like the catalytic site to improve stability and activity. However, few h
Externí odkaz:
https://doaj.org/article/bdf600cd9a9a42b89094005221841e04
Autor:
Wahhida Latip, Raja Noor Zaliha Raja Abd Rahman, Adam Thean Chor Leow, Fairolniza Mohd Shariff, Mohd Shukuri Mohamad Ali
Publikováno v:
PeerJ, Vol 4, p e2420 (2016)
A gene encoding a thermotolerant lipase with broad pH was isolated from an Antarctic Pseudomonas strain AMS3. The recombinant lipase AMS3 was purified by single-step purification using affinity chromatography, yielding a purification fold of approxim
Externí odkaz:
https://doaj.org/article/d36576dedc834725bbdfb0273b0e86af