Výsledky vyhledávání - "Adam T. Zarth"

Data from Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications

Autor: Melbourne F. Hovell, Stephen S. Hecht, Georg E. Matt, Dale A. Chatfield, C. Richard Hofstetter, Steven G. Carmella, Maram A. Younis, Adam T. Zarth, Reem M. Daffa, Sandy Liles, Sheila R. Jackson, Noura O. Kassem, Nada O.F. Kassem

Background: Benzene is a human hematotoxicant and a leukemogen that causes lymphohematopoietic cancers, especially acute myelogenous leukemia. We investigated uptake of benzene in hookah smokers and non-smokers attending hookah social events in natur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6423a92ab0f32d8a7823616123f8a8cf
https://doi.org/10.1158/1055-9965.c.6516324

Zobrazit plný text záznamu

Investigation of 2′-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by N′-Nitrosonornicotine Metabolism

Autor: Stephen S. Hecht, Pramod Upadhyaya, Erik S. Carlson, Yupeng Li, Adam T. Zarth

Publikováno v: Chemical Research in Toxicology. 34:1004-1015

The International Agency for Research on Cancer has classified the tobacco-specific nitrosamines N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as "carcinogenic to humans" (Group 1). To exert its carcinogenicity,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9079d77afe14333a3f45591b159bc000
https://doi.org/10.1021/acs.chemrestox.1c00012

Zobrazit plný text záznamu

Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

Autor: Pramod Upadhyaya, Stephen S. Hecht, Adam T. Zarth, Peter W. Villalta, Bin Ma, Irina Stepanov, Erik S. Carlson

Publikováno v: Chemical Research in Toxicology

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a powerful lung carcinogen in animal models and is considered a causative factor for lung cancer in tobacco users. NNK is stereoselectively and reversibly metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856e324800f8e6592a163614499761cd
https://doi.org/10.1021/acs.chemrestox.7b00281

Zobrazit plný text záznamu

Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Autor: Irina Stepanov, Stephen S. Hecht, Bin Ma, Adam T. Zarth, Peter W. Villalta, Erik S. Carlson, Pramod Upadhyaya

Publikováno v: Carcinogenesis. 39:232-241

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a powerful lung carcinogen in animal models and is considered a causative factor for lung cancer in people who use tobacco products. NNK undergoes metabolic acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764a431fe7c31f18ac1c44fbbff2d56b
https://doi.org/10.1093/carcin/bgx135

Zobrazit plný text záznamu

Pyridylhydroxybutyl and pyridyloxobutyl DNA phosphate adduct formation in rats treated chronically with enantiomers of the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

Autor: Irina Stepanov, Peter W. Villalta, Bin Ma, Adam T. Zarth, Erik S. Carlson, Stephen S. Hecht

Publikováno v: Mutagenesis. 32:561-570

The tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is metabolically converted to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in a reaction which is both stereoselective and reversible. NNAL is also a lu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a29602283946395569f27de2fe4f20a
https://doi.org/10.1093/mutage/gex031

Zobrazit plný text záznamu

Acrolein Exposure in Hookah Smokers and Non-Smokers Exposed to Hookah Tobacco Secondhand Smoke: Implications for Regulating Hookah Tobacco Products

Autor: Sheila R. Jackson, Sandy Liles, Reem M. Daffa, Steven G. Carmella, Noura O Kassem, Nada O.F. Kassem, Stephen S. Hecht, Dale A. Chatfield, Adam T. Zarth, Melbourne F. Hovell

Publikováno v: Nicotine & Tobacco Research. 20:492-501

Introduction Acrolein is a highly ciliatoxic agent, a toxic respiratory irritant, a cardiotoxicant, and a possible carcinogen present in tobacco smoke including hookah tobacco. Methods 105 hookah smokers and 103 non-smokers attended exclusively hooka

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456571abafbc46abe71c0ac85da6dc9f
https://doi.org/10.1093/ntr/ntx133

Zobrazit plný text záznamu

Identification of 4-(3-Pyridyl)-4-oxobutyl-2′-deoxycytidine Adducts Formed in the Reaction of DNA with 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone: A Chemically Activated Form of Tobacco-Specific Carcinogens

Autor: Pramod Upadhyaya, Stephen S. Hecht, Anna K. Michel, Adam T. Zarth

Publikováno v: ACS Omega
ACS Omega, Vol 2, Iss 3, Pp 1180-1190 (2017)

Metabolic activation of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) and N′-nitrosonornicotine (NNN, 2) results in the formation of 4-(3-pyridyl)-4-oxobutyl (POB)-DNA adducts, several of whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46fd82e359ff655497ea5b3c90c6710
http://europepmc.org/articles/PMC5377278

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání