Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Adam T. Comstock"'
Autor:
Toby C. Lewis, Ediri E. Metitiri, Graciela B. Mentz, Xiaodan Ren, Ashley R. Carpenter, Adam M. Goldsmith, Kyra E. Wicklund, Breanna N. Eder, Adam T. Comstock, Jeannette M. Ricci, Sean R. Brennan, Ginger L. Washington, Kendall B. Owens, Bhramar Mukherjee, Thomas G. Robins, Stuart A. Batterman, Marc B. Hershenson, the Community Action Against Asthma Steering Committee
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships. Methods Children underw
Externí odkaz:
https://doaj.org/article/dccaf5886cec4e07a387f47611fb78b8
Publikováno v:
BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)
IntroductionQuercetin is a plant flavonoid and has potent antioxidant and anti-inflammatory properties. In a preclinical model of chronic obstructive pulmonary disease (COPD), quercetin reduced markers of both oxidative stress and lung inflammation a
Externí odkaz:
https://doaj.org/article/841a77adb1f3430482c15205949bcff4
Publikováno v:
BMJ Open Respiratory Research
BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)
BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)
IntroductionQuercetin is a plant flavonoid and has potent antioxidant and anti-inflammatory properties. In a preclinical model of chronic obstructive pulmonary disease (COPD), quercetin reduced markers of both oxidative stress and lung inflammation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764edad6fba93e1d54e03d6917e03b34
https://doi.org/10.1136/bmjresp-2018-000392
https://doi.org/10.1136/bmjresp-2018-000392
Autor:
Mohammad Farazuddin, Vikram Srivastava, Umadevi S. Sajjan, Yaxun Jing, Rahul Mishra, Adam T. Comstock
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199612 (2018)
PLoS ONE
PLoS ONE
Acute exacerbations are the major cause of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). Rhinovirus, which causes acute exacerbations may also accelerate progression of lung disease in these patients. Current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a354ebab73715f9a6227ac2b6329df7
http://europepmc.org/articles/PMC6033397?pdf=render
http://europepmc.org/articles/PMC6033397?pdf=render
Autor:
Shyamala Ganesan, Benjamin L. Unger, Marc B. Hershenson, Adam T. Comstock, Uma S. Sajjan, Andrea N. Faris
Publikováno v:
Journal of Virology. 88:3705-3718
Barrier dysfunction of airway epithelium may increase the risk for acquiring secondary infections or allergen sensitization. Both rhinovirus (RV) and polyinosinic-polycytidilic acid [poly(I·C)], a double-stranded RNA (dsRNA) mimetic, cause airway ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67adbcec37cfa8205290e3e653ae8ae
https://doi.org/10.1128/jvi.03039-13
https://doi.org/10.1128/jvi.03039-13
Autor:
Ginger L. Washington, Toby C. Lewis, Bhramar Mukherjee, Jeannette M. Ricci, Adam T. Comstock, Kendall B. Owens, Xiaodan Ren, Kyra E. Wicklund, Sean Brennan, Graciela Mentz, Thomas G. Robins, Adam M. Goldsmith, Breanna N. Eder, Marc B. Hershenson, Ediri E. Metitiri, Megan P. Walsh, Stuart Batterman
Publikováno v:
Annals of Allergy, Asthma & Immunology
Background Upper respiratory tract viral infections cause asthma exacerbations in children. However, the impact of natural colds on children with asthma in the community, particularly in the high-risk urban environment, is less well defined. Objectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cf5b1c65b5d2773ff1f6cf72761dcc
Autor:
Umadevi S. Sajjan, Sangbrita Chattoraj, Asamanja Chattoraj, Shyamala Ganesan, Benjamin L. Unger, Marc B. Hershenson, Andrea N. Faris, Adam T. Comstock
Rhinovirus (RV), which causes exacerbation in patients with chronic airway diseases, readily infects injured airway epithelium and has been reported to delay wound closure. In this study, we examined the effects of RV on cell repolarization and diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4db99d8dbf94cc8e8a36eb3da33ea8a
https://europepmc.org/articles/PMC5070101/
https://europepmc.org/articles/PMC5070101/
Autor:
Jeffrey L. Curtis, Shyamala Ganesan, Joanne Sonstein, Andrea N. Faris, Uma S. Sajjan, Adam T. Comstock
Publikováno v:
The American Journal of Pathology. 180(1):61-72
Nontypeable Haemophilus influenzae (NTHi) is an important bacterial pathogen associated with lower respiratory tract colonization and with acute exacerbations and disease progression in chronic obstructive pulmonary disease (COPD). Why the immune sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8dc39cf38adf9868096f9962a322cd
Autor:
Adam T. Comstock, Duc Thinh Pham, Uma S. Sajjan, Magdalena H. Hudy, Yaxun Jing, David Proud, Benjamin L. Unger, Mohammad Farazuddin, Shyamala Ganesan, Adam S. Lauring
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 197(6)
Airway epithelial cells are the major target for rhinovirus (RV) infection and express proinflammatory chemokines and antiviral cytokines that play a role in innate immunity. Previously, we demonstrated that RV interaction with TLR2 causes ILR-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2deb50155a5dcab66fe09eb922706fb3
https://pubmed.ncbi.nlm.nih.gov/27503209
https://pubmed.ncbi.nlm.nih.gov/27503209
Autor:
Andrea N. Faris, Adam T. Comstock, Sangbrita Chattoraj, Wai Ming Lee, Umadevi S. Sajjan, Shyamala Ganesan
Publikováno v:
Infection and Immunity. 79:4131-4145
Despite increased morbidity associated with secondary respiratory viral infections in cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa infection, the underlying mechanisms are not well understood. Here, we investigated the effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920d068ef9a0dc36703cedfc7e9f0344
https://doi.org/10.1128/iai.05120-11
https://doi.org/10.1128/iai.05120-11