Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Adam T, Waickman"'
Autor:
Chad Gebo, Céline S C Hardy, Benjamin D McElvany, Nancy R Graham, Joseph Q Lu, Shima Moradpour, Jeffrey R Currier, Heather Friberg, Gregory D Gromowski, Stephen J Thomas, Gary C Chan, Sean A Diehl, Adam T Waickman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 10, p e1012683 (2024)
Dengue virus (DENV) is the causative agent of dengue, a mosquito-borne disease that represents a significant and growing public health burden around the world. A unique pathophysiological feature of dengue is immune-mediated enhancement, wherein pree
Externí odkaz:
https://doaj.org/article/47e6647e5ba84022b144652ccec09d03
Autor:
Adam D Wegman, Mitchell J Waldran, Lauren E Bahr, Joseph Q Lu, Kristen E Baxter, Stephen J Thomas, Adam T Waickman
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011616 (2023)
Dengue represents a growing public health burden worldwide, accounting for approximately 100 million symptomatic cases and tens of thousands of fatalities yearly. Prior infection with one serotype of dengue virus (DENV) is the greatest known risk fac
Externí odkaz:
https://doaj.org/article/9990bd46c0304633bf9daa5cb2d3e1c0
Autor:
Adam T. Waickman, Kaitlin Victor, Krista Newell, Tao Li, Heather Friberg, Kathryn E. Foulds, Mario Roederer, Diane L. Bolton, Jeffrey R. Currier, Robert Seder
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Vaccine-elicited SARS-CoV-2 antibody responses are an established correlate of protection against viral infection in humans and nonhuman primates. However, it is less clear that vaccine-induced immunity is able to limit infection-elicited inflammatio
Externí odkaz:
https://doaj.org/article/e4e7681338584bf98cc3b00823799e77
Autor:
Michael K. McCracken, Caitlin H. Kuklis, Chandrika B. Kannadka, David A. Barvir, Mark A. Sanborn, Adam T. Waickman, Hayden C. Siegfried, Kaitlin A. Victor, Kristin L. Hatch, Rafael De La Barrera, Shannon D. Walls, Wiriya Rutvisuttinunt, Jeffrey R. Currier, Heather Friberg, Richard G. Jarman, Gregory D. Gromowski
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract Antibody-dependent enhancement (ADE) is suspected to influence dengue virus (DENV) infection, but the role ADE plays in vaccination strategies incorporating live attenuated virus components is less clear. Using a heterologous prime-boost str
Externí odkaz:
https://doaj.org/article/d8ee938ae9d948e0b132ccac35634eaa
Autor:
Mahinbanu Mammadli, Rebecca Harris, Liye Suo, Adriana May, Teresa Gentile, Adam T. Waickman, Alaji Bah, Avery August, Elmar Nurmemmedov, Mobin Karimi
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 12, Pp n/a-n/a (2021)
Abstract Regulatory T cells (Tregs) play an important role in controlling autoimmunity and limiting tissue damage and inflammation. IL2‐inducible T cell kinase (Itk) is part of the Tec family of tyrosine kinases and is a critical component of T cel
Externí odkaz:
https://doaj.org/article/4b2076bcc0cb4825ad858a8c9823abea
Autor:
Adam D. Wegman, Hengsheng Fang, Alan L. Rothman, Stephen J. Thomas, Timothy P. Endy, Michael K. McCracken, Jeffrey R. Currier, Heather Friberg, Gregory D. Gromowski, Adam T. Waickman
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Dengue virus (DENV) is a prevalent human pathogen, infecting approximately 400 million individuals per year and causing symptomatic disease in approximately 100 million. A distinct feature of dengue is the increased risk for severe disease in some in
Externí odkaz:
https://doaj.org/article/4682c9b4478a45098e43e2013851ecef
Autor:
Hung D. Nguyen, Sidhartha Chaudhury, Adam T. Waickman, Heather Friberg, Jeffrey R. Currier, Anders Wallqvist
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The dengue virus circulates as four distinct serotypes, where a single serotype infection is typically asymptomatic and leads to acquired immunity against that serotype. However, the developed immunity to one serotype is thought to underlie the sever
Externí odkaz:
https://doaj.org/article/5570f83ee3c740fbbd66a66cd3b5f949
Autor:
Adam T. Waickman, Kaitlin Victor, Tao Li, Kristin Hatch, Wiriya Rutvisuttinunt, Carey Medin, Benjamin Gabriel, Richard G. Jarman, Heather Friberg, Jeffrey R. Currier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Using a combination of single-cell RNA sequencing and TCR clonotype analysis on longitudinal samples from dengue vaccinated individuals, Waickman et al. here define a transcriptional signature in acutely-activated T cells that is associated with dura
Externí odkaz:
https://doaj.org/article/397665ccccdd42deb850a4519fa9b750
Autor:
Mahinbanu Mammadli, Weishan Huang, Rebecca Harris, Hui Xiong, Samuel Weeks, Adriana May, Teresa Gentile, Jessica Henty-Ridilla, Adam T. Waickman, Avery August, Alaji Bah, Mobin Karimi
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102286- (2021)
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for hematological malignancies, due to graft-versus-leukemia (GVL) activity mediated by alloreactive donor T cells. However, graft-versus-host disease (GVHD
Externí odkaz:
https://doaj.org/article/9117c9a8368744a7a223a2f8a4f036fd
Autor:
Adam T Waickman, Heather Friberg, Gregory D Gromowski, Wiriya Rutvisuttinunt, Tao Li, Hayden Siegfried, Kaitlin Victor, Michael K McCracken, Stefan Fernandez, Anon Srikiatkhachorn, Damon Ellison, Richard G Jarman, Stephen J Thomas, Alan L Rothman, Timothy Endy, Jeffrey R Currier
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009240 (2021)
Dengue human infection studies present an opportunity to address many longstanding questions in the field of flavivirus biology. However, limited data are available on how the immunological and transcriptional response elicited by an attenuated chall
Externí odkaz:
https://doaj.org/article/c813a299acb74fa5ac588a7f0fd49988