Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution

Autor: Jack Hedberg, Adam Studebaker, Luke Smith, Chun-Yu Chen, Jesse J. Westfall, Maren Cam, Amy Gross, Ilse Hernandez-Aguirre, Alexia Martin, Doyeon Kim, Ravi Dhital, Yeaseul Kim, Ryan D. Roberts, Timothy P. Cripe, Elaine R. Mardis, Kevin A. Cassady, Jeffrey Leonard, Katherine E. Miller

Publikováno v: Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 39-55 (2023)

Oncolytic viruses, modified for tumor-restricted infection, are a promising cancer immunotherapeutic, yet much remains to be understood about factors driving their activity and outcome in the tumor microenvironment. Here, we report that oncolytic her

Externí odkaz: https://doaj.org/article/4ec2f4c531974d0cbbb997bdf92d6293

Data from Regulation of TORC1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E Brain Tumor Models

Autor: Peter J. Houghton, Raushan T. Kurmasheva, Sandeep Burma, C. David James, John A. Kalapurakal, Xiao-Nan Li, Mari Kogiso, Joel E. Michalek, Qianqian Liu, Adam Studebaker, Samson Ghilu, Kathryn M. Bondra, Fuyang Li

Purpose:We investigated why three patient-derived xenograft (PDX) childhood BRAFV600E-mutant brain tumor models are highly sensitive to trametinib. Mechanisms of acquired resistance selected in situ, and approaches to prevent resistance were also exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0409952db8fe60655f86ed6525282f
https://doi.org/10.1158/1078-0432.c.6532494.v1

Supplementary Table from Regulation of TORC1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E Brain Tumor Models

Autor: Peter J. Houghton, Raushan T. Kurmasheva, Sandeep Burma, C. David James, John A. Kalapurakal, Xiao-Nan Li, Mari Kogiso, Joel E. Michalek, Qianqian Liu, Adam Studebaker, Samson Ghilu, Kathryn M. Bondra, Fuyang Li

Supplementary Table from Regulation of TORC1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E Brain Tumor Models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38510a681975e6bd8b5372e754e006ee
https://doi.org/10.1158/1078-0432.22487301

Tumor Models (In Vivo/In Vitro)

Autor: Gerald Steiner, Stefan Rutkowski, David M. Loeb, Jochen Herms, Samuel D. Rabkin, G.J. Kaspers, Ling-Yuan Kong, Reiner Salzer, Tokomo Ozawa, Anneke C. Navis, Rob C. Hoeben, John J. Lannutti, Nalin Gupta, ZhaoBin Zhang, Alfredo Quinones-Hinojosa, Dolores Hambardzumyan, Jon D. Weingart, Mariano S. Viapiano, Michał Nowicki, Gregory J. Riggins, Celina Crisman, Chen Gang, Elena I. Fomchenko, Martine L.M. Lamfers, Yuan Rong, Carol Tucker-Burden, I Zondervan, P. Wesseling, Deepak Kamnasaran, Enio A. Chiocca, Jose Bergeron, Julia Sisti, Sanne K. van den Hengel, Anat Stemmer-Rachamimov, Nikolaus Schultz, Gabriele Schackert, Jun Wei, Jonathan P. Yun, Bob C. Hamans, Fabien G. Lafaille, Shengguo Li, Amparo Wolf, Paula A. Agudelo, Jochem K H Spoor, Rolf Bjerkvig, Abhijit Guha, Sameer Agnihotri, Preeti Shah, Andreas Lorenz, Gregory N. Fuller, Xiaoyan Zhu, Nesrin Sabha, Michael Lim, Stephen Yip, Frits Thorsen, Viviane Tabar, Allison Stelling, Judith W. M. Jeuken, William T. Curry, Arend Heerschap, Nduka Amankulor, Hiroaki Wakimoto, Lakshmi Katuri, Yasuyuki Aoki, Hadie Adams, Jenneke Kloezeman, Raelene Endersby, P. van der Valk, T. Wurdinger, Wesley Hsu, André Von Bueren, Antonio Aliaga, Suzanne J. Baker, Matthias Kirsch, David W. Ellison, Sander Idema, Yuhui Yang, Norbert Ajewung, Massimo Squatrito, C. Molthoff, D. H. Meijer, Gayatry Mohapatra, Pim J. French, Rutger K. Balvers, An Claes, M. Bugiani, Hans A. Kretzschmar, Michael Castelli, Pui K. Li, Thomas Kosztowski, Ganesh Rao, Zev A. Binder, W. Vos, M. Barazas, Eric C. Holland, Amanda M. Katz, Anne Kleijn, Chunxu Qu, Jeffrey N. Bruce, P.M. van der Stoop, Robert L. Martuza, Sidney Croul, Ahmed Mohyeldin, Shante Williams, Jed Johnson, Heike Immervoll, Aurelia Peraud, W.P. Vandertop, Sherri Rankin, Erwin Van Meir, Anne Lenferink, Adam Studebaker, Amy B. Heimberger, Lorenz Studer, Clemens M F Dirven, E. Hulleman, Sieger Leenstra, Ziya L. Gokaskan, Peter Canoll, Sagar R. Shah, Henry Brem, Pieter Wesseling, Ulrike S. Trojahn, Gary L. Gallia, Ryuichi Kanai, Vafi Salmasi, Mengqing Xiang, Julia Pöschl, D.J. Brat, Stephen D. Nimer, Craig Soderquist, Lionel M. Chow, T. Lagerweij, Tiffany Doucette, Jean-Paul Wolinsky, Elena Bazzoli, Jörg-Christian Tonn, Christoph Krafft, Maureen O'Connor-McCourt, Ulrich Schüller, Andreas von Deimling, Inderjit Daphu, Rintaro Hashizume, Alessandro Olivi, Adam Sonabend, William P.J. Leenders, Lisa M. DeAngelis, Liang Lei, C.D. James, D. Noske, Cameron Brennan, Sean E. Lawler, Junyuan Zhang, B. Hamans, Corey Raffel, Jinbo Wang, Barry J. Bedell, V. Caretti, Zachary R. Barnard

Publikováno v: Neuro-Oncology. 12:iv130-iv136

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d849b4c95f927567cbc1ec9d594ee97a
https://doi.org/10.1093/neuonc/noq116.s20