Výsledky vyhledávání - "Adam Stonier"

Integrated economic and experimental framework for screening of primary recovery technologies for high cell density CHO cultures

Autor: Suzanne S. Farid, Daria Popova, Adam Stonier, David Pain, Nigel J. Titchener-Hooker

Publikováno v: Biotechnology Journal

Increases in mammalian cell culture titres and densities have placed significant demands on primary recovery operation performance. This article presents a methodology which aims to screen rapidly and evaluate primary recovery technologies for their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e314726c7023d7697c70d12560211c
http://europepmc.org/articles/PMC4999028

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Integration of stochastic simulation with multivariate analysis: Short-term facility fit prediction

Autor: Suzanne S. Farid, David Pain, Nina F. Thornhill, Nick Hutchinson, Adam Stonier, Ashley Westlake

Publikováno v: Biotechnology Progress. 29:368-377

This article describes a decision-support tool to help pinpoint the potential root causes of sub-optimal short-term facility fit issues in biopharmaceutical facilities. This was achieved by creating a tool that integrated stochastic simulation with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ff2db8019ffe3d2eb40c101091be26
https://doi.org/10.1002/btpr.1678

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Representative mammalian cell culture test materials for assessment of primary recovery technologies: a rapid method with industrial applicability

Autor: Daria, Popova, Adam, Stonier, David, Pain, Nigel J, Titchener-Hooker, Suzanne S, Farid

Publikováno v: Biotechnology Journal

Mammalian cell culture material is often difficult to produce accurately and reproducibly for downstream studies. This article presents a methodology for the creation of a set of cell culture test materials where key variables including cell density,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::586ed3582f838bb54c86abc078a22d64
https://pubmed.ncbi.nlm.nih.gov/25377169

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Integration of stochastic simulation with advanced multivariate and visualisation analyses for rapid prediction of facility fit issues in biopharmaceutical processes

Autor: Dave Pain, Ashley Westlake, Suzanne S. Farid, Nicholas Hutchinson, Adam Stonier, Nina F. Thornhill

Publikováno v: ResearcherID

This paper describes a decision-support tool that integrates Monte Carlo simulation data derived using a stochastic discrete-event simulation model to mimic process fluctuations with advanced multivariate statistical techniques to help pinpoint the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9bb1bb766b09aee97ceb7dd4167ecb
https://doi.org/10.1016/b978-0-444-54298-4.50050-7

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Dynamic Simulation Framework for Design of Lean Biopharmaceutical Manufacturing Operations

Autor: Suzanne S. Farid, Adam Stonier, Nick Hutchinson, Martin Smith

Upstream advances in mammalian cell culture processes have increased pressures for downstream processes intensification efforts to alleviate downstream bottlenecks and improve process economics. This paper describes a decision support tool to facilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b27ac2316057665bfb505fff833162d5
https://doi.org/10.1016/s1570-7946(09)70178-6

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